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Cancer Treatment Induced Bone Loss (CTIBL) Due to Hormone Ablation Therapy - Prolia® (denosumab)

Prolia® is an FDA-approved therapy for patients with cancer treatment-induced bone loss (CTIBL) due to hormone ablation. Review dosing information and clinical trial results.

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Cancer Treatment Induced Bone Loss (CTIBL) Due to Hormone Ablation Therapy - Prolia® (denosumab) | proliapro.com Reviews
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Prolia® is an FDA-approved therapy for patients with cancer treatment-induced bone loss (CTIBL) due to hormone ablation. Review dosing information and clinical trial results.
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Cancer Treatment Induced Bone Loss (CTIBL) Due to Hormone Ablation Therapy - Prolia® (denosumab) | proliapro.com Reviews

https://proliapro.com

Prolia® is an FDA-approved therapy for patients with cancer treatment-induced bone loss (CTIBL) due to hormone ablation. Review dosing information and clinical trial results.

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1

Bone Mineral Density Increase in Prostate Cancer Patients Receiving Prolia® (denosumab)

http://www.proliapro.com/ctibl/prostate-cancer/increased-bone-mineral-density.html

This site is for U.S. Healthcare Professionals only. BMD and Fracture Risk When. On Aromatase Inhibitor (AI) Therapy. BMD and Fracture Risk. Is indicated as a treatment to increase bone mass in men at high risk for fracture receiving androgen deprivation therapy for nonmetastatic prostate cancer. In these patients Prolia. Also reduced the incidence of vertebral fractures. Should not receive XGEVA. May cause fetal harm. It is not known whether Prolia. Is excreted in human milk. At 24 months (. Increased B...

2

Increase in Bone Mineral Density in Breast Cancer Patients Receiving Prolia® (denosumab)

http://www.proliapro.com/ctibl/breast-cancer/increased-bone-mineral-density.html

This site is for U.S. Healthcare Professionals only. BMD and Fracture Risk When. On Aromatase Inhibitor (AI) Therapy. BMD and Fracture Risk. See fracture reduction data now. Available from the ABCSG-18. Is indicated as a treatment to increase bone mass in men at high risk for fracture receiving androgen deprivation therapy for nonmetastatic prostate cancer. In these patients Prolia. Also reduced the incidence of vertebral fractures. Should not receive XGEVA. Is excreted in human milk. Demonstrated a cont...

3

Prolia® (denosumab) CTIBL Due to Hormone Ablation Site Map

http://www.proliapro.com/ctibl/sitemap.html

This site is for U.S. Healthcare Professionals only. BMD and Fracture Risk When. On Aromatase Inhibitor (AI) Therapy. BMD and Fracture Risk. BMD and Fracture Risk. When on AI Therapy. BMD and Fracture Risk When on ADT. Efficacy - New Vertebral Fracture. Is indicated as a treatment to increase bone mass in men at high risk for fracture receiving androgen deprivation therapy for nonmetastatic prostate cancer. In these patients Prolia. Also reduced the incidence of vertebral fractures. Symptoms have include...

4

Access and Reimbursement Information for Prolia® (denosumab)

http://www.proliapro.com/ctibl/prolia-reimbursement.html

This site is for U.S. Healthcare Professionals only. BMD and Fracture Risk When. On Aromatase Inhibitor (AI) Therapy. BMD and Fracture Risk. Amgen is committed to helping your patients and your practice access Prolia. Amgen FIRST STEP™ Program. No out-of-pocket cost for the first dose. No income eligibility requirement. For subsequent doses, Amgen will pay the out-of-pocket amount in excess of $25 per dose, up to $3,000 in assistance per calendar year. For full eligibility criteria and limitations. Inter...

5

Vertebral Fracture in Men – Risk Reduction of New Fractures

http://www.proliapro.com/ctibl/prostate-cancer/vertebral-fracture.html

This site is for U.S. Healthcare Professionals only. BMD and Fracture Risk When. On Aromatase Inhibitor (AI) Therapy. BMD and Fracture Risk. Is indicated as a treatment to increase bone mass in men at high risk for fracture receiving androgen deprivation therapy for nonmetastatic prostate cancer. In these patients Prolia. Also reduced the incidence of vertebral fractures. Should not receive XGEVA. May cause fetal harm. It is not known whether Prolia. Is excreted in human milk. Up to 36 months. Relative r...

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Prolia® (denosumab) Safety Profile

http://www.proliahcp.com/why-prolia/safety-profile/index.html

Safety Information - Risk Evaluation and Mitigation Strategy (REMS). Pivotal Phase 3 Fracture Trial. Open-Label Extension Study of Pivotal Phase 3 Fracture Trial. Denosumab) is contraindicated in patients with hypocalcemia, women who are pregnant, and patients with a history of systemic hypersensitivity to any component of the product. Patients receiving Prolia. Should not receive XGEVA. Clinically significant hypersensitivity including anaphylaxis has been reported with Prolia. For the treatment of post...

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ProliaPlus and Treatment Reminders

http://www.proliahcp.com/proliaplus/treatment-reminders/index.html

Safety Information - Risk Evaluation and Mitigation Strategy (REMS). Denosumab) is contraindicated in patients with hypocalcemia, women who are pregnant, and patients with a history of systemic hypersensitivity to any component of the product. Patients receiving Prolia. Should not receive XGEVA. Clinically significant hypersensitivity including anaphylaxis has been reported with Prolia. Hypocalcemia may worsen with the use of Prolia. Patients should be monitored for adverse outcomes. Helps your practice ...

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Prolia® (denosumab) Why a Celebrated Actress Chose Prolia®

http://www.proliahcp.com/who-to-treat/blythe-danner/index.html

Safety Information - Risk Evaluation and Mitigation Strategy (REMS). High Risk Postmenopausal Osteoporosis. Why a Celebrated Actress Chose Prolia. To Increase Bone Mass in Men with Osteoporosis at High Risk for Fracture. Denosumab) is contraindicated in patients with hypocalcemia, women who are pregnant, and patients with a history of systemic hypersensitivity to any component of the product. Patients receiving Prolia. Should not receive XGEVA. Hypocalcemia may worsen with the use of Prolia. Treatment of...

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ProliaPlus and Obtaining Prolia® (denosumab)

http://www.proliahcp.com/proliaplus/accessing-prolia/index.html

Safety Information - Risk Evaluation and Mitigation Strategy (REMS). Denosumab) is contraindicated in patients with hypocalcemia, women who are pregnant, and patients with a history of systemic hypersensitivity to any component of the product. Patients receiving Prolia. Should not receive XGEVA. Clinically significant hypersensitivity including anaphylaxis has been reported with Prolia. Hypocalcemia may worsen with the use of Prolia. Patients should be monitored for adverse outcomes. Can help you find lo...

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Prolia® (denosumab) Important Safety Information

http://www.proliahcp.com/isi.html

Safety Information - Risk Evaluation and Mitigation Strategy (REMS). Important Safety Information About Prolia. Is contraindicated in patients with hypocalcemia. Pre-existing hypocalcemia must be corrected prior to initiating Prolia. Is contraindicated in women who are pregnant and may cause fetal harm. Prolia. Is contraindicated in patients with a history of systemic hypersensitivity to any component of the product. Reactions have included anaphylaxis, facial swelling and urticaria. ONJ, which can occur...

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Prolia® (denosumab) Pivotal Phase 3 Fracture Trial

http://www.proliahcp.com/why-prolia/phase-3-trial/index.html

Safety Information - Risk Evaluation and Mitigation Strategy (REMS). Pivotal Phase 3 Fracture Trial. Open-Label Extension Study of Pivotal Phase 3 Fracture Trial. Denosumab) is contraindicated in patients with hypocalcemia, women who are pregnant, and patients with a history of systemic hypersensitivity to any component of the product. Patients receiving Prolia. Should not receive XGEVA. Clinically significant hypersensitivity including anaphylaxis has been reported with Prolia. For the treatment of post...

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Prolia® (denosumab) Site Map

http://www.proliahcp.com/sitemap/index.html

Safety Information - Risk Evaluation and Mitigation Strategy (REMS). Denosumab) is contraindicated in patients with hypocalcemia, women who are pregnant, and patients with a history of systemic hypersensitivity to any component of the product. Patients receiving Prolia. Should not receive XGEVA. Clinically significant hypersensitivity including anaphylaxis has been reported with Prolia. Hypocalcemia may worsen with the use of Prolia. Patients should be monitored for adverse outcomes. Open-Label Extension...

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Prolia® (denosumab) for Treatment to Increase Bone Mass in Men with Osteoporosis at High Risk for Fracture

http://www.proliahcp.com/who-to-treat/men-with-high-risk-osteoporosis/index.html

Safety Information - Risk Evaluation and Mitigation Strategy (REMS). High Risk Postmenopausal Osteoporosis. Why a Celebrated Actress Chose Prolia. To Increase Bone Mass in Men with Osteoporosis at High Risk for Fracture. Denosumab) is contraindicated in patients with hypocalcemia, women who are pregnant, and patients with a history of systemic hypersensitivity to any component of the product. Patients receiving Prolia. Should not receive XGEVA. Hypocalcemia may worsen with the use of Prolia. Treatment of...

proliahcp.com proliahcp.com

ProliaPlus and Medicare Insurance

http://www.proliahcp.com/proliaplus/medicare-insurance/index.html

Safety Information - Risk Evaluation and Mitigation Strategy (REMS). Denosumab) is contraindicated in patients with hypocalcemia, women who are pregnant, and patients with a history of systemic hypersensitivity to any component of the product. Patients receiving Prolia. Should not receive XGEVA. Clinically significant hypersensitivity including anaphylaxis has been reported with Prolia. Hypocalcemia may worsen with the use of Prolia. Patients should be monitored for adverse outcomes. 100% Medicare Part B...

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About ProliaPlus

http://www.proliahcp.com/proliaplus/about/index.html

Safety Information - Risk Evaluation and Mitigation Strategy (REMS). Denosumab) is contraindicated in patients with hypocalcemia, women who are pregnant, and patients with a history of systemic hypersensitivity to any component of the product. Patients receiving Prolia. Should not receive XGEVA. Clinically significant hypersensitivity including anaphylaxis has been reported with Prolia. Hypocalcemia may worsen with the use of Prolia. Patients should be monitored for adverse outcomes. Select a topic below...

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Thursday, August 13, 2015. Please protect the confidentiality of your patients by not revealing or sharing login credentials. To register for ProliaPlus. Online, click here:. Charlotte, NC 28222-0807. Reduces the incidence of vertebral, nonvertebral, and hip fractures. Is contraindicated in patients with hypocalcemia. Pre-existing hypocalcemia must be corrected prior to initiating Prolia. Is contraindicated in women who are pregnant and may cause fetal harm. Prolia. Should not receive XGEVA. Symptoms hav...

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Cancer Treatment Induced Bone Loss (CTIBL) Due to Hormone Ablation Therapy - Prolia® (denosumab)

This site is for U.S. Healthcare Professionals only. Is the Only FDA-Approved Therapy for Cancer Treatment Induced Bone Loss Due to Hormone AblationTherapy [1]. For Breast Cancer patients:. Significant and long-term increase in BMD. For Prostate Cancer patients:. Significant increase in BMD. Sustained reduction in new vertebral fractures. For out-of-pocket cost assistance for your patients:. Is a convenient subcutaneous injection administered by a health care professional. Prostate cancer patients on ADT.

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Adverse Event of Special Interest Form. Postmarketing Active Safety Surveillance Program. One Amgen Center Dr. Thousand Oaks, CA 91320-9938. Dear Healthcare Professional,. Welcome to the Prolia. Postmarketing Active Safety Surveillance Program. This program will help Amgen further understand the long-term safety profile of Prolia. It is important for companies such as Amgen to obtain ongoing information on the safety of its products. While participation in the program is not necessary to prescribe Prolia.

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