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Clemens R. Scherzer, M.D. | The Laboratory for Neurogenomics

Brigham and Women's Hospital. Clemens R. Scherzer, M.D. Associate Professor of Neurology. Harvard NeuroDiscovery Biomarker Program. Brigham and Women's Hospital. Postdoctoral Position in Computational Neuroscience. How does the human genome program 86 billion highly specialized neurons in the human brain? How is this program disrupted by diseases of the brain? Genomic dark matter and personalized medicine. A glimpse into the future of biomedicine. Science Translational Medicine, 2014 » more.

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Clemens R. Scherzer, M.D. | The Laboratory for Neurogenomics | scherzerlaboratory.org Reviews
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Brigham and Women's Hospital. Clemens R. Scherzer, M.D. Associate Professor of Neurology. Harvard NeuroDiscovery Biomarker Program. Brigham and Women's Hospital. Postdoctoral Position in Computational Neuroscience. How does the human genome program 86 billion highly specialized neurons in the human brain? How is this program disrupted by diseases of the brain? Genomic dark matter and personalized medicine. A glimpse into the future of biomedicine. Science Translational Medicine, 2014 » more.
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1 harvard medical school
2 massachusetts general hospital
3 research
4 publications
5 news
6 patients
7 team
8 co director
9 associate neurologist
10 email cscherzer@partners org
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Clemens R. Scherzer, M.D. | The Laboratory for Neurogenomics | scherzerlaboratory.org Reviews

https://scherzerlaboratory.org

Brigham and Women's Hospital. Clemens R. Scherzer, M.D. Associate Professor of Neurology. Harvard NeuroDiscovery Biomarker Program. Brigham and Women's Hospital. Postdoctoral Position in Computational Neuroscience. How does the human genome program 86 billion highly specialized neurons in the human brain? How is this program disrupted by diseases of the brain? Genomic dark matter and personalized medicine. A glimpse into the future of biomedicine. Science Translational Medicine, 2014 » more.

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Clemens R. Scherzer, M.D. | The Laboratory for Neurogenomics

http://www.scherzerlaboratory.org/publications/index.html

Click here for complete PubMed listing. 2010 Oct 6;2(52):52ra73. doi: 10.1126/scitranslmed.3001059. PGC-1α, a potential therapeutic target for early intervention in Parkinson's disease. Laboratory for Neurogenomics, Center for Neurologic Diseases, Harvard Medical School and Brigham and Women's Hospital, 65 Landsdowne Street, Suite 307A, Cambridge, MA 02139, USA. Neurobiology: Powerless against Parkinson's. PMID: 20926834 [PubMed - indexed for MEDLINE] PMCID: PMC3129986. Proc Natl Acad Sci U S A. Laborato...

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Clemens R. Scherzer, M.D. | The Laboratory for Neurogenomics

http://www.scherzerlaboratory.org/members/index.html

Clemens R. Scherzer, MD. Zhixiang Liao, M.S. Research Specialist and Lab Manager. Xianjun Dong, PhD. Instructor, Harvard Medical School. Bioinformatics Engineer and Assistant Scientist, Brigham and Women’s Hospital. Bin Zheng, Ph.D. Harvard NeuroDiscovery Center Biomarker Study. Shuchi Mittal, Ph.D. Ganqiang Liu, Ph.D. Postdoctoral Fellow in Computational Neuroscience. David Gritsch, MD. Chizoba Umeh, M.D. Instructor, Department of Neurology. Division of Movement Disorders. Brigham and Women's Hospital.

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Clemens R. Scherzer, M.D. | The Laboratory for Neurogenomics

http://www.scherzerlaboratory.org/news

Hot Topic: A New Biomarker for Parkinson’s Disease? Movement Disorders, December 15, 2015. Alpha-synuclein: Promising molecular test for Parkinson's disease. NETPR Highlights, 2015. A glimpse into the future of biomedicine. Science Translational Medicine, 2014. Michael J. Fox Foundation Awards. The Harvard Biomarker Study's big plan. Lancet Neurology, June 26, 2013. Biomarker for Huntington's disease identified. Harvard Gazette, October 3, 2011. Study: Brain energy crisis may spark Parkinson's. Neurology...

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Clemens R. Scherzer, M.D. | The Laboratory for Neurogenomics

http://www.scherzerlaboratory.org/patients/index.html

Patients seeking appointments with Dr. Scherzer should call the clinic appointment coordinator at:. Mass General Hospital (617-726-5532) or. Brigham and Women's Hospital (617-525-5504).

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Clemens R. Scherzer, M.D. | The Laboratory for Neurogenomics

http://www.scherzerlaboratory.org/index.html

Brigham and Women's Hospital. Clemens R. Scherzer, M.D. Associate Professor of Neurology. Harvard NeuroDiscovery Biomarker Program. Brigham and Women's Hospital. Postdoctoral Position in Computational Neuroscience. How does the human genome program 86 billion highly specialized neurons in the human brain? How is this program disrupted by diseases of the brain? Genomic dark matter and personalized medicine. Hot Topic: A New Biomarker for Parkinson’s Disease? NETPR Highlights, 2015 » more.

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One Tip Per Day: Be cautious of using grep --colour=always

http://onetipperday.sterding.com/2015/05/be-cautious-of-using-grep-colouralways.html

One Tip Per Day. Learning notes for Unix, Perl, R, HTML, Javascript, Google API and mostly Bioinformatics. Friday, May 22, 2015. Be cautious of using grep - colour=always. I noticed that grep - colour=always. Can embed additional code (for coloring, for example, [ 01;31m [ K [ m [ K. In your text, which could lead downstream confusion. Here is one such example:. Echo 1 2 3 grep 2. Echo 1 2 3 grep 2 cat -v. Echo 1 2 3 grep - colour=always 2. Echo 1 2 3 grep - colour=always 2 cat -v. The solution is to use.

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One Tip Per Day: Which version should I install? 32 bit or 64 bit? Ubuntu or CentOS?

http://onetipperday.sterding.com/2015/05/which-version-should-i-install-32-bit.html

One Tip Per Day. Learning notes for Unix, Perl, R, HTML, Javascript, Google API and mostly Bioinformatics. Thursday, May 21, 2015. Which version should I install? 32 bit or 64 bit? I was posting two relevant articles on this topic:. Unix vs. Linux. Http:/ onetipperday.blogspot.com/2014/07/unix-vs-linux.html). Which version of tools I should install? I386 vs. x86 64, and 32bit vs. 64bit kernel. Http:/ onetipperday.blogspot.com/2013/02/software-vs-hardware-i386-vs-x8664-and.html). In my case, I used:.

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One Tip Per Day: Dopamine, L-DOPA, catecholamines, TH, Nuur1 etc.

http://onetipperday.sterding.com/2015/08/dopamine-l-dopa-catecholamines-th-nuur1.html

One Tip Per Day. Learning notes for Unix, Perl, R, HTML, Javascript, Google API and mostly Bioinformatics. Wednesday, August 05, 2015. Dopamine, L-DOPA, catecholamines, TH, Nuur1 etc. Catecholamines (儿茶酚胺) is the collection name for three neurotransmitters: epinephrine. L-DOPA is its precursor. Its corresponding drug is called levodopa. L-DOPA is produced from the amino acid L- tyrosine. By the enzyme tyrosine hydroxylase. Tyrosine cannot pass the BBB (blood brain barrier), but L-DOPA can. How to tell wh...

onetipperday.sterding.com onetipperday.sterding.com

One Tip Per Day: PLINK2 vs. SNAP for linkage disequilibrium (LD) calculation

http://onetipperday.sterding.com/2015/09/linkage-disequilibrium-ld-calculation.html

One Tip Per Day. Learning notes for Unix, Perl, R, HTML, Javascript, Google API and mostly Bioinformatics. Friday, September 11, 2015. PLINK2 vs. SNAP for linkage disequilibrium (LD) calculation. Among other ways to calculate SNPs in linkage disequilibrium (LD), two methods have been used in many literatures: PLINK2 and SNAP. With PLINK2, SNPs in LD can be calculated using parameters like:. PLINK2 -r2 dprime - ld-window-kb 1000 - ld-window 10 - ld-window-r2 0.8. And the number of SNPs apart ( - ld-window.

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One Tip Per Day: My note on multiple testing

http://onetipperday.sterding.com/2015/12/my-note-on-multiple-testing.html

One Tip Per Day. Learning notes for Unix, Perl, R, HTML, Javascript, Google API and mostly Bioinformatics. Friday, December 04, 2015. My note on multiple testing. It's not a shame to put a note on something (probably) everyone knows and you thought you know but actually you are not 100% sure. Multiple testing is such a piece in my knowledge map. Type I error (false positive) and Type II error (false negative):. When we do a hypothesis test, we can categorize the result into the following 2x2 table:.

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One Tip Per Day: Calculate the odd of winning Powerball in R

http://onetipperday.sterding.com/2016/01/calculate-odd-of-winning-powerball-in-r.html

One Tip Per Day. Learning notes for Unix, Perl, R, HTML, Javascript, Google API and mostly Bioinformatics. Tuesday, January 12, 2016. Calculate the odd of winning Powerball in R. This Wednesday’s Powerball grand prize already climbed up to $. 15 BILLION. If you choose to cash out, it would be $930 million. And it keeps increasing…. So, what’s the odd of winning the jackpot prize? Here is the game rule according to Powerball.com:. 8230;we draw five white balls out of a drum with 69 balls and one red ball.

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One Tip Per Day: Best way to draw heatmap for publication

http://onetipperday.sterding.com/2016/07/best-way-to-draw-heatmap-for-publication.html

One Tip Per Day. Learning notes for Unix, Perl, R, HTML, Javascript, Google API and mostly Bioinformatics. Friday, July 08, 2016. Best way to draw heatmap for publication. Here are two tips I can share if you were also working on a big dataset towards a high quality heatmap:. 1 Don't generate PDF using pheatmap(). As (i) the file is unnecessarily SUPER large if you have a lot of data points in the heatmap, so that you can kill your Illustrator; (ii) annoying grey boxes added to the grip (see here. Questi...

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One Tip Per Day: Dopamine is the "Kim Kardashian of molecule" in brain -- I like this!

http://onetipperday.sterding.com/2015/12/dopamine-is-kim-kardashian-of-molecule.html

One Tip Per Day. Learning notes for Unix, Perl, R, HTML, Javascript, Google API and mostly Bioinformatics. Wednesday, December 09, 2015. Dopamine is the "Kim Kardashian of molecule" in brain - I like this! I read this from the article: http:/ www.theguardian.com/science/2013/feb/03/dopamine-the-unsexy-truth. The main dopaminergic pathways of the human brain. (Wikipedia). And it's interesting to know the impressive people in the Kardashian family. That really impress me. Subscribe to: Post Comments (Atom).

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One Tip Per Day: SNP allele coding schema

http://onetipperday.sterding.com/2015/12/snp-allele-coding-schema.html

One Tip Per Day. Learning notes for Unix, Perl, R, HTML, Javascript, Google API and mostly Bioinformatics. Wednesday, December 09, 2015. SNP allele coding schema. There are three types of different SNP allele coding schemes (so far). No idea why the scientists have to make things so confusing sometimes. See more details here: http:/ www.ncbi.nlm.nih.gov/books/NBK44455/#Build.define the term orientation as us. Plus/Minus strand for Genome Annotation, HapMap, 1000 Genome Project. Important note: The FinalR...

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One Tip Per Day: A parallel and fast way to download multiple files

http://onetipperday.sterding.com/2015/10/a-parallel-and-fast-way-to-download.html

One Tip Per Day. Learning notes for Unix, Perl, R, HTML, Javascript, Google API and mostly Bioinformatics. Monday, October 05, 2015. A parallel and fast way to download multiple files. We can write a short script to download multiple files easily in command, e.g. For i in X Y Z; do wget http:/ www.site.com/folder/$i.url; done. If we want them to run in background (so that in a pseudo-parallel way), we can use -b option for wget. Here is my solution: axel parallel. Parallel -a urls.file axel. Deeply under...

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Clemens R. Scherzer, M.D. | The Laboratory for Neurogenomics

Brigham and Women's Hospital. Clemens R. Scherzer, M.D. Associate Professor of Neurology. Harvard NeuroDiscovery Biomarker Program. Brigham and Women's Hospital. Postdoctoral Position in Computational Neuroscience. How does the human genome program 86 billion highly specialized neurons in the human brain? How is this program disrupted by diseases of the brain? Genomic dark matter and personalized medicine. A glimpse into the future of biomedicine. Science Translational Medicine, 2014 » more.

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