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VomiFix: Alleviating Brain-Gut Problems - What We Do

VomiFix is a preclinical contract research organization (CRO) that specializes in mechanisms affecting the Brain-Gut axis to minimize the side effects of drugs, and to also discover new anti-emetic...

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VomiFix: Alleviating Brain-Gut Problems - What We Do | vomifix.com Reviews
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VomiFix is a preclinical contract research organization (CRO) that specializes in mechanisms affecting the Brain-Gut axis to minimize the side effects of drugs, and to also discover new anti-emetic...
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1 what we do
2 emesis
3 anti emetic studies
4 emetic liability testing
5 investigating gastric dysrhythmia
6 about vomifix
7 suncus murinus
8 coupons
9 reviews
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VomiFix: Alleviating Brain-Gut Problems - What We Do | vomifix.com Reviews

https://vomifix.com

VomiFix is a preclinical contract research organization (CRO) that specializes in mechanisms affecting the Brain-Gut axis to minimize the side effects of drugs, and to also discover new anti-emetic...

SUBDOMAINS

jar-labs.vomifix.com jar-labs.vomifix.com

JAR-Labs - Home

Prof C.K. Yeung. Professor John A. Rudd. Cancer Biology and Experimental Therapeutics. School of Biomedical Sciences. Lo Kwee-Seong Integrated Biomedical Sciences Building. Chinese University of Hong Kong. Join or visit JAR-Labs. Collaboration with Helsinn shows the ghrelin agonists, HM01 and HM02, antagonise chemotherapy- and motion-induced emesis - these findings were presenting at the recent MASCC conference in Adelaide, Australia. Laboratory Rotations - New PhD Project. School of Biomedical Sciences.

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1

Emesis - VomiFix: Alleviating Brain-Gut Problems

http://www.vomifix.com/emesis.html

VomiFix: Alleviating Brain-Gut Problems. Nausea and emesis during drug treatment or disease can be debilitating and can severely impact the quality of life. VomiFix is committed to both understanding the mechanisms involved in emesis control, and evaluating potential therapies. We have a proven track record in translational research. And water consumption during emesis experiments as a non-specific measure of nausea. Ferrets do not become motion-sick, so to evaluate the anti-emetic properties of compound...

2

Anti-Emetic Studies - VomiFix: Alleviating Brain-Gut Problems

http://www.vomifix.com/anti-emetic-studies.html

VomiFix: Alleviating Brain-Gut Problems. How to Discover Anti-Emetic Potential. In the late 1980s, we worked on the development of 5-HT3 receptor antagonists and also explored the concept of the use of broad inhibitory anti-emetic drugs for use in man. We now have 20 years experience with this model, having investigated many compounds for anti-emetic potential and effects on other side effects associated with chemotherapy. It is also known that individuals that are susceptible to motion sickness also are...

3

Emetic Liability Testing - VomiFix: Alleviating Brain-Gut Problems

http://www.vomifix.com/emetic-liability-testing.html

VomiFix: Alleviating Brain-Gut Problems. The development of a new chemical entity through conventional animal testing fails to detect the side effects of nausea and emesis until studies are taken into man. At this point, the financial cost of discontinuing development can be unfortunate and crippling. We have in-depth knowledge of emetic mechanisms and can provide advice and expert consultation on compound development. We have access to preclinical models including the ferret and.

4

About VomiFix - VomiFix: Alleviating Brain-Gut Problems

http://www.vomifix.com/about-vomifix.html

VomiFix: Alleviating Brain-Gut Problems. Our Experience and the Use of Technology are Unmatched. We profile compounds for emetic liability and anti-emetic potential and can perform very basic-to-complex experiments, depending on individual clients' needs. We use c-fos immunohistochemistry to study brainstem areas involved in emesis control, and a combination of forebrain areas, that may be involved in the control of nausea.

5

Investigating Gastric Dysrhythmia - VomiFix: Alleviating Brain-Gut Problems

http://www.vomifix.com/investigating-gastric-dysrhythmia.html

VomiFix: Alleviating Brain-Gut Problems. Slow Waves in Health and Disease. Motility disorders of the gastrointestinal tract increase with aging and inflammatory conditions; constipation and faecal incontinence are the most common symptoms in the elderly. Several control systems are responsible for the regulation of normal transit of contents through the gastrointestinal tract. One of the most important involves local reflexes controlled by the enteric nervous system. In the mouse,. The approach involves ...

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VomiFix: Alleviating Brain-Gut Problems - What We Do

VomiFix: Alleviating Brain-Gut Problems. VomiFix is a preclinical contract research organization (CRO) that specializes in mechanisms affecting the Brain-Gut axis to minimize the side effects of drugs, and to also discover new anti-emetic drugs to improve patient care in a variety of situations. VomiFix is committed to understanding the mechanisms involved in emesis control, and evaluating potential therapies. We use ferrets and.

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