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New Page 117-dmag geldanamycin derivate that is soluble in water
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17-dmag geldanamycin derivate that is soluble in water
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17dmag is a water soluble derivate of Geldanamycin. 17-(Dimethylaminoethylamino)-17-demethoxygeldanamycin (17DMAG) is the first water-soluble analogue of 17AAG. This Hsp90 inhibitor seems to be good in preclinical studies. [ 1. 17DMAG has very good bioavailability, is freely distributed to the body tissues, and is metabolized significantly less than is 17AAG[ 2. 1 Workman P., 2003. Overview: translating Hsp90 biology into Hsp90 drugs. Curr Cancer Drug Targets 3(5):297-300. The heat shock protein Hsp90 [?
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