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Ascomycin Macrolactams fact sheet

Ascomycin macrolactams belong to a new group of immunosuppressive, immunomodulatory and anti-inflammatory agents. Due to their chemical nature they are water-soluble and therefore, in principle, suitable for topical treatment of dermatological disorders. Ascomycin macrolactam derivative has been approved for short-term and intermittent long-term therapy in the treatment of mild to moderate atopic dermatitis. Studies on an immunosuppressive macrolactam, ascomycin: synthesis of a C-33 hydroxyl derivative.

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Ascomycin Macrolactams fact sheet | ascomycin.noneto.com Reviews

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Ascomycin macrolactams belong to a new group of immunosuppressive, immunomodulatory and anti-inflammatory agents. Due to their chemical nature they are water-soluble and therefore, in principle, suitable for topical treatment of dermatological disorders. Ascomycin macrolactam derivative has been approved for short-term and intermittent long-term therapy in the treatment of mild to moderate atopic dermatitis. Studies on an immunosuppressive macrolactam, ascomycin: synthesis of a C-33 hydroxyl derivative.

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1 ascomycin macrolactams

2 ascomycin references

3 ascomycin at fermentek

4 actinomycin

5 aflatoxin

6 anisomycin

7 aphidicolin

8 ascomycin

9 bleomycin

10 brefeldin

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Ascomycin Macrolactams fact sheet | ascomycin.noneto.com Reviews

https://ascomycin.noneto.com

Ascomycin macrolactams belong to a new group of immunosuppressive, immunomodulatory and anti-inflammatory agents. Due to their chemical nature they are water-soluble and therefore, in principle, suitable for topical treatment of dermatological disorders. Ascomycin macrolactam derivative has been approved for short-term and intermittent long-term therapy in the treatment of mild to moderate atopic dermatitis. Studies on an immunosuppressive macrolactam, ascomycin: synthesis of a C-33 hydroxyl derivative.

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Discovery of ascomycin analogs with potent topical but weak systemic activity for treatment of inflammatory skin diseases

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Curr Pharm Des 1998 Oct;4(5):367-79. Discovery of ascomycin analogs with potent topical but weak systemic activity for treatment of inflammatory skin diseases. Mollison KW, Fey TA, Gauvin DM, Sheets MP, Smith ML, Pong M, Krause R, Miller L, Or YS, Kawai M, Wagner R, Wiedeman PE, Clark RF, Gunawardana IW, Rhoades TA, Henry CL, Tu NP, BaMaung NY, Kopecka H, Liu L, Xie Q, Lane BC, Trevillyan JM, Marsh K, Luly JR, et al. Abbott Laboratories, Abbott Park, Illinois, USA. karl.mollison@abbott.com.

2

The ascomycin macrolactam pimecrolimus (Elidel, SDZ ASM 981) is a potent inhibitor of mediator release from human dermal mast cells and peripheral blood basophils

http://ascomycin.noneto.com/a0.htm

J Allergy Clin Immunol 2001 Aug;108(2):275-80. The ascomycin macrolactam pimecrolimus (Elidel, SDZ ASM 981) is a potent inhibitor of mediator release from human dermal mast cells and peripheral blood basophils. Zuberbier T, Chong SU, Grunow K, Guhl S, Welker P, Grassberger M, Henz BM. Department of Dermatology and Allergy, Charite, Humboldt University Berlin, Germany.

3

Studies on an immunosuppressive macrolactam, ascomycin: synthesis of a C-33 hydroxyl derivative

http://ascomycin.noneto.com/a3.htm

Bioorg Med Chem Lett 1998 Apr 21;8(8):935-8. Studies on an immunosuppressive macrolactam, ascomycin: synthesis of a C-33 hydroxyl derivative. Kawai M, Gunawardana IW, Mollison KW, Hsieh GC, Lane BC, Luly JR. Pharmaceutical Products Division, Abbott Laboratories, Abbott Park, IL 60064-3500, USA.

4

Ascomycin macrolactam derivative SDZ ASM 981 inhibits the release of granule-associated mediators and of newly synthesized cytokines in RBL 2H3 mast cells in an immunophilin-dependent manner

http://ascomycin.noneto.com/a4.htm

Arch Dermatol Res 1998 Sep;290(9):501-7. Ascomycin macrolactam derivative SDZ ASM 981 inhibits the release of granule-associated mediators and of newly synthesized cytokines in RBL 2H3 mast cells in an immunophilin-dependent manner. Hultsch T, Muller KD, Meingassner JG, Grassberger M, Schopf RE, Knop J. University Hautklinik Mainz, Germany.

5

Effectiveness of the ascomycin macrolactam SDZ ASM 981 in the topical treatment of atopic dermatitis

http://ascomycin.noneto.com/a5.htm

Arch Dermatol 1998 Jul;134(7):805-9. Effectiveness of the ascomycin macrolactam SDZ ASM 981 in the topical treatment of atopic dermatitis. Van Leent EJ, Graber M, Thurston M, Wagenaar A, Spuls PI, Bos JD. Department of Dermatology, Academic Medical Center, University of Amsterdam, The Netherlands.

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An intermediary role for the tremorgenic mycotoxin TR-2 in the biosynthesis of verruculogen.

http://verruculogen.noneto.com/3.htm

Biochem J 1983 Sep 15;214(3):991-3. An intermediary role for the tremorgenic mycotoxin TR-2 in the biosynthesis of verruculogen. Willingale J, Perera KP, Mantle PG.

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Verruculogen Facts Sheet

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A comparative study of sheep and pigs given the tremorgenic mycotoxins verruculogen and penitrem A.

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Res Vet Sci 1982 Sep;33(2):183-7. A comparative study of sheep and pigs given the tremorgenic mycotoxins verruculogen and penitrem A. Peterson DW, Penny RH, Day JB, Mantle PG.

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Ascomycin Macrolactams fact sheet

Would you like to make this site your homepage? It's fast and easy. Yes, Please make this my home page! Don't show this to me again. Ascomycin macrolactams belong to a new group of immunosuppressive, immunomodulatory and anti-inflammatory agents. Due to their chemical nature they are water-soluble and therefore, in principle, suitable for topical treatment of dermatological disorders. Discovery of ascomycin analogs with potent topical but weak systemic activity for treatment of inflammatory skin diseases.

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Ascomycin, Streptomyces hygroscopicus var ascomyceticus. Soluble in DMSO and Ethanol. Melting Point: 156 -161 degree. Ascomycin, also called Immunomycin, FR-900520, FK520, is an ethyl analog of FK506 (Tacrolimus) with strong immunosuppressant properties. It can be used to treat autoimmune diseases and skin diseases, and can help prevent rejection after an organ transplant. Ascomycin acts by binding to immunophilins, especially macrophilin-12. It appears that Ascomycin inhibits the production of Th1 (...

ascomycin.noneto.com

Ascomycin Macrolactams fact sheet

Ascomycin macrolactams belong to a new group of immunosuppressive, immunomodulatory and anti-inflammatory agents. Due to their chemical nature they are water-soluble and therefore, in principle, suitable for topical treatment of dermatological disorders. Ascomycin macrolactam derivative has been approved for short-term and intermittent long-term therapy in the treatment of mild to moderate atopic dermatitis. Studies on an immunosuppressive macrolactam, ascomycin: synthesis of a C-33 hydroxyl derivative.

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