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News & Media. A New Era of Medicine. Gene therapy represents a new paradigm in human health, with the potential to resolve unmet medical needs by addressing the underlying causes of disease. Gene therapy has the potential to deliver dramatic disease modifying effects and potentially life-long cures from a single infusion of genetically-modified cells.

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AvroBio | | avrobio.com Reviews
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News & Media. A New Era of Medicine. Gene therapy represents a new paradigm in human health, with the potential to resolve unmet medical needs by addressing the underlying causes of disease. Gene therapy has the potential to deliver dramatic disease modifying effects and potentially life-long cures from a single infusion of genetically-modified cells.
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2 scientific founders
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5 rare disease
6 cancer immunotherapy
7 safety system
8 gene vector
9 programs
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AvroBio | | avrobio.com Reviews

https://avrobio.com

News & Media. A New Era of Medicine. Gene therapy represents a new paradigm in human health, with the potential to resolve unmet medical needs by addressing the underlying causes of disease. Gene therapy has the potential to deliver dramatic disease modifying effects and potentially life-long cures from a single infusion of genetically-modified cells.

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Board of Directors | AvroBio

http://www.avrobio.com/company/board-of-directors-2

News & Media. Bruce Booth DPhil - Chairman. Prior to joining Atlas in 2005, Bruce was a consultant at McKinsey and Company, as well as an investor for Caxton Health Holdings. As a British Marshall Scholar, Bruce received a D.Phil. (PhD) in molecular immunology from Oxford University. His work focused on the study of HIV and tumor immune responses. He received a BS in biochemistry, summa cum laude, from The Pennsylvania State University. Christopher Paige PhD, FCAHS. Scott Requadt JD, MBA.

2

Rare Disease | AvroBio

http://www.avrobio.com/rare-disease

News & Media. Our approach is to genetically modify a patient’s own cells by adding a functional copy of the faulty gene. CD34 hematopoetic stem cells are transduced via a lentiviral vector to express the normal gene. The modified cells are then infused into the patient via a one-time procedure. Pacienza N, Yoshimitsu M, Mizue N, Au BC, Wang JC, Fan X, Takenaka T, Medin JA. Lentivector transduction improves outcomes over transplantation of human HSCs alone in NOD/SCID/Fabry mice.

3

Partners | AvroBio

http://www.avrobio.com/partners-2

News & Media. Atlas Venture is a biotech-focused, early-stage venture capital firm that creates and invests in life sciences startup companies in the USA. Atlas is based in Cambridge, Massachusetts. Since 1993, Atlas has invested in over 150 early stage life sciences companies. The University Health Network (UHN) is made up of Princess Margaret Cancer Center, Toronto General Hospital, Toronto Rehabilitation Institute, and Toronto Western Hospital. UHN is one of Canada’s largest teaching hospitals.

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Company | AvroBio

http://www.avrobio.com/company

News & Media. AVROBIO Inc.,. A leader in lentiviral-based gene therapies, is a clinical stage company developing transformative, life-changing therapies that have the potential to transform patients’ lives in a single dose. The catalyst for creating AVROBIO. Is to accelerate scientific breakthroughs related to the convergence of cell and gene therapies. The patient’s own cells can be effectively modified to deliver novel genes to cure serious debilitating disease.

5

Programs | AvroBio

http://www.avrobio.com/programs

News & Media. AVR-RD-01 Fabry Disease Phase I Trial. The primary objective is to evaluate the safety and toxicity of autologous stem cell transplantation with mobilized CD34 cells transduced to express the enzyme alpha galactosidase A (alpha-gal A). AVR-ONC-01 Acute Myeloid Leukemia (AML) Phase I Trial. The primary objective is to demonstrate the safety and tolerability of infusing autologous AML cells transduced to express IL-12 into patients and to determine the maximum tolerated dose.

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Industry Consortium | Centre for Commercialization of Regenerative Medicine

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Cell Reprogramming and Engineering. Fee-for-Service iPSC Line Generation. CCRM in the News. CCRM Conferences and Workshops. Supported Conferences and Workshops. OIRM Seminars and Rounds. CCRM's Secure IP Portal. Click logo to visit site). CCRM's Industry Consortium Members. Benefits of Industry Consortium Membership. Industry Consortium members are entitled to all of the benefits below, as well as those afforded to Associate Members. Represent industry on CCRM’s Commercialization Review Committee. Access...

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News & Media. A New Era of Medicine. Gene therapy represents a new paradigm in human health, with the potential to resolve unmet medical needs by addressing the underlying causes of disease. Gene therapy has the potential to deliver dramatic disease modifying effects and potentially life-long cures from a single infusion of genetically-modified cells.

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