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Bioreactor, bioreactor systems, engineered tissues, engineered grafts, regenerative medicine, cellular therapy, cartilage repair, cell-based grafts, chondrocytes, cartilage graft, clinical trial, clinical study, tissue engineering, perfusion bioreactor, 3D cell culture, scaffold, University Hospital Basel, University Bristol, University Zagreb, Cellec, Presens, Octane, Holostem, FinCeramica, IOR,

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Bioreactor, bioreactor systems, engineered tissues, engineered grafts, regenerative medicine, cellular therapy, cartilage repair, cell-based grafts, chondrocytes, cartilage graft, clinical trial, clinical study, tissue engineering, perfusion bioreactor, 3D cell culture, scaffold, University Hospital Basel, University Bristol, University Zagreb, Cellec, Presens, Octane, Holostem, FinCeramica, IOR,
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1 BIO-COMET
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5 supported by the European Union under its Seventh Framework Programme
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Home | biocomet.eu Reviews

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Bioreactor, bioreactor systems, engineered tissues, engineered grafts, regenerative medicine, cellular therapy, cartilage repair, cell-based grafts, chondrocytes, cartilage graft, clinical trial, clinical study, tissue engineering, perfusion bioreactor, 3D cell culture, scaffold, University Hospital Basel, University Bristol, University Zagreb, Cellec, Presens, Octane, Holostem, FinCeramica, IOR,

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1

Press

http://www.biocomet.eu/press

Martin, I., Ireland, H., Baldomero, H., Massimo, D., Saris, D.B., Passweg, J. The survey on cellular and engineered tissue therapies in Europe in 2013, Tissue Engineering Part A. December 2015, ahead of print. Martin, I., Ireland, H., Baldomero, H., Passweg, J. The survey on cellular and engineered tissue therapies in Europe in 2012, Tissue Engineering Part A. January 2015, 21(1-2):1-13. doi: 10.1089/ten.TEA.2014.0515. Epub 2014 Nov 25. Knee exposed to continuous passive motion, Osteoarthritis Cartilage&...

2

Project Overview

http://www.biocomet.eu/project-overview

Despite significant achievements in the field of regenerative medicine and the enormous potential for engineered tissue products, significant hurdles have prevented cellular therapies from gaining widespread clinical adoption. Manufacturing related issues have been proposed as key challenges to be addressed for the translation of regenerative therapies to the clinic and the successful commercialisation of engineered products. Innovative features of the proposed tissue engineering strategy will include:.

3

Scientific Approach

http://www.biocomet.eu/project-overview/scientific-approach

The BIO-COMET work plan has been divided into 8 work packages, WPs. WP1. Focuses on the development, refinement, and qualification of an automated and controlled bioreactor-based tissue manufacturing system. In WP2. Will test the full manufacturing process, including bioreactor performance and tissue transport, and the subsequent production of the grafts needed for the animal study and the clinical trial in full compliance with regulatory issues. WP5. Will address the regulatory, financial, and marketing...

4

Background

http://www.biocomet.eu/project-overview/background

Current tissue engineering paradigm. The BIO-COMET concept is for bioreactor-based manufacture of tissue grafts. Bioreactors have the potential to overcome the current limitations by:. Providing a controlled physico-chemical culture environment, which tightly regulates the bioprocesses, minimising process and product variability;. Including monitoring and data management systems which offer a high level of traceability and increased compliance to regulatory guidelines;. Cell therapy for cartilage repair.

5

Publications

http://www.biocomet.eu/press/publication

Martin, I., Ireland, H., Baldomero, H., Massimo, D., Saris, D.B., Passweg, J. The survey on cellular and engineered tissue therapies in Europe in 2013, Tissue Engineering Part A. December 2015, ahead of print. Martin, I., Ireland, H., Baldomero, H., Passweg, J. The survey on cellular and engineered tissue therapies in Europe in 2012, Tissue Engineering Part A. January 2015, 21(1-2):1-13. doi: 10.1089/ten.TEA.2014.0515. Epub 2014 Nov 25. Knee exposed to continuous passive motion, Osteoarthritis Cartilage&...

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Projekti | CIRTT - Centar za istraživanje, razvoj i transfer tehnologije Sveučilišta u Zagrebu

http://cirtt.unizg.hr/o-nama/projekti

CIRTT – Centar za istraživanje, razvoj i transfer tehnologije Sveučilišta u Zagrebu. Program provjere inovativnog koncepta PoC. Poduzetništvo zasnovano na znanju. Sveučilište u Zagrebu i poduzetništvo. Sveučilišna tiskara d.o.o. Hrvatska sveučilišna naklada d.o.o. Dormitorij d.o.o. BICRO BIOcentar d.o.o. Comprehensive Water Technology d.o.o. (CWT). HighTechVets d.o.o. Centar za promet i logistiku d.o.o. Tvrtke zasnovane na znanju. Otvoreni natječaji – Arhiva. Trenutno Centar provodi sljedeće projekte:.

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BIO-COMET, Bioreactor-based, clinically oriented manufacturing of engineered tissues. Is a four-year small and medium sized enterprise (SME)-targeted collaborative research project, supported by the European Union under its Seventh Framework Programme.

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