bioinfor.me

karchinlab.org

Karchin Lab Johns Hopkins University

http://karchinlab.org/people.html

The William R. Brody Faculty Scholar, Johns Hopkins University. Institute for Computational Medicine, Department of Biomedical Engineering, Department of Oncology. About the Karchin Lab. Dave Masica, Ph.D. Department of Biomedical Engineering. Institute for Computational Medicine. Department of Biomedical Engineering. Institute for Computational Medicine. Department of Biomedical Engineering. Institute for Computational Medicine. Department of Biomedical Engineering. Institute for Computational Medicine.

karchinlab.org

Karchin Lab Johns Hopkins University POSE

http://karchinlab.org/apps/appPose.html

POSE @ Karchin lab. POSE (Phenotype-optimized Sequence Ensembles). Is a supervised learning method that predicts the functional significance of missense mutations in a specific protein. Current release is POSE 0.60, last updated on 01/12/2015. POSE software is intended for those with substantial bioinformatics and Python expertise. POSE is free for non-commercial use. Commercial users should contact the Johns Hopkins Technology Transfer office. Documentation for the developer.

karchinlab.org

Karchin Lab Johns Hopkins University SNVBox

http://karchinlab.org/apps/appSnvBox.html

SNVBox @ Karchin lab. SNVBox is intended for those with substantial bioinformatics and Linux system expertise and access to a large-memory Linux server. It is free for non-commercial use. For more details please refer to our Software License. Commercial users should contact the Johns Hopkins Technology Transfer office. SNVBox can be used independently of CHASM and VEST software, however these tools use SNVBox as a source of predictive features, and SNVBox currently shares a Wiki site with them.

karchinlab.org

Karchin Lab Johns Hopkins University

http://karchinlab.org/publications.html

Tokheim C, Papdopoulis N, Kinzler KW, Vogelstein B, Karchin R (2016) Evaluating the evaluation of cancer driver genes. J Am Med Inform Assoc Jun 21 pii: ocw069. doi: 10.1093/jamia/ocw069. [Epub ahead of print]. Mascia DL, Karchin R (2016) Towards increasing the clinical relevance of in silico methods to predict pathogenic missense variants. PLoS Computational Biology. May 12;12(5):e1004725. Cancer Research. Apr. 28.pii: canres.3190.2015. [Epub ahead of print]. Douville C, Masica DL, Stenson PD, Cooper DN...

karchinlab.org

Karchin Lab Johns Hopkins University SCHISM

http://karchinlab.org/apps/appSchism.html

SCHISM @ Karchin lab. SCHISM (SubClonal Hierarchy Inference from Somatic Mutations). Is a computational framework that reconstructs tumor subcolonal phylogenies using somatic mutation cellularities in patient's tumor sample(s). SCHISM combines information about somatic mutation cellularity (aka mutation cancer cell fraction) across all tumor sample(s) available from a patient in a hypothesis testing framework to identify the statistical support for the lineage relationship between each pair of mutations ...

karchinlab.org

Karchin Lab Johns Hopkins University VEST

http://karchinlab.org/apps/appVest.html

VEST @ Karchin lab. VEST (Variant Effect Scoring Tool). Is a machine learning method that predicts the functional significance of missense mutations observed through genome sequencing, allowing mutations to be prioritized in subsequent functional studies, based on the probability that they impair protein activity. It is free for non-commercial use. For more details please refer to our Software License. Commercial users should contact the Johns Hopkins Technology Transfer office. Documentation for the user.

karchinlab.org

Karchin Lab Johns Hopkins University POSE

http://karchinlab.org/apps/appMoca.html

MOCA @ Karchin lab. MOCA (Multivariate Organization of Combinatorial Alterations). Is a non-parametric algorithm to discover constellations of dichotomous features that predict a phenotype of interest with high sensitivity and specficity. Current release is MOCA 0.75, last updated on 02/04/2014. MOCA software is intended for those with substantial bioinformatics and Python expertise. MOCA is free for non-commercial use. Commercial users should contact the Johns Hopkins Technology Transfer office.

karchinlab.org

Karchin Lab Johns Hopkins University SCHISM

http://karchinlab.org/apps/appClump.html

CLUMP @ Karchin lab. CLUMP (CLustering by Mutation Position). Is a method that performs unsupervised clustering of amino acid residue positions where variants occur, without any prior knowledge of their functional importance. CLUMP is free for non-commercial use. For more details please refer to our Software License. Commercial users should contact the Johns Hopkins Technology Transfer office. Current release is CLUMP.1.0.0, last updated on 04/26/2015. CLUMP-1.0.0.tar.gz. Documentation for the user.

karchinlab.org

Karchin Lab Johns Hopkins University BOMP

http://karchinlab.org/apps/appBomp.html

BOMP @ Karchin lab. BOMP (Burden or Mutation Position gene scoring tool). Software uses a novel hybrid likelihood model to identify phenotype-associated genes from sequencing data in case/control study designs. BOMP runs on Java = 1.6.0 Current release is BOMP 1.0. last updated on 01/23/2013. BOMP is free for non-commercial use. Commercial users should contact the Johns Hopkins Technology Transfer office. Documentation for the user. Download BOMP jar file here. R) How is BOMP different from VT and SKAT?

jefworks.com

BioHazards – JEFworks

http://jefworks.com/portfolio/biohazards

Jean Fan works on research and other fun stuff. Portfolio / previous and ongoing fun projects. Was established to teach students and enthusiasts the fundamentals of protein evolution. To make the material accessible and exciting, lessons are conveyed through an intuitive and attractive gaming environment and framed into the context of common human health concerns and topics. The project is maintained and developed by the Karchin lab. Rachel Karchin: Principal investigator. Jean Fan: Software engineer.