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BioMed Notes | biomednotes.blogspot.com Reviews
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BioMed Notes | biomednotes.blogspot.com Reviews

https://biomednotes.blogspot.com

Life Science News and Discussion

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1

BioMed Notes: December 2012

http://biomednotes.blogspot.com/2012_12_01_archive.html

Sunday, December 9, 2012. The peptide binding site accounts for the MHC link to Rheumatoid Arthritis. That genes within the major histocompatibility complex (MHC, human HLA) influence susceptibility to rheumatoid arthritis (RA) has been known for over 40 years, even before HLA nomenclature was well established (e.g., Dick et al. 1975. However, the few “classical” HLA genes constitute only a small fraction of the hundreds genes within the MHC. And 14,974 health, ethnically matched controls. A valine at th...

2

BioMed Notes: Would you like some E. coli with that?

http://biomednotes.blogspot.com/2012/01/would-you-like-some-e-coli-with-that.html

Sunday, January 22, 2012. Would you like some E. coli with that? An epidemic of bloody stools and failing kidneys, some with hemolytic uremic syndrome ( HUS. Appeared in Germany in May 2011 and subsequently 15 other countries. By late July when the epidemic had subsided, a total of 3,816 cases - including 54 deaths - were reported in Germany, 845 of which included HUS. Rasko and colleagues cultured E. coli bacteria. Isolated from a 64 year old woman from Hamburg, Germany, who did not. Together with 7 oth...

3

BioMed Notes: Recipe for Developing Th17 cells

http://biomednotes.blogspot.com/2013/04/recipe-for-developing-th17-cells.html

Sunday, April 21, 2013. Recipe for Developing Th17 cells. Cells, so-called because they make the interleukin-17 (IL17) that is required for protecting the mucosa against infection by bacteria and fungi. Development of cell lineages is controlled externally by cytokines and internally by “master” transcription factors. RORgt ( retinoic-acid-receptor-related orphan receptors. Other TFs may replace these for inducing some Th17 genes. They also identify several putative new Th17 regulators, including the AP-...

4

BioMed Notes: March 2015

http://biomednotes.blogspot.com/2015_03_01_archive.html

Sunday, March 15, 2015. Stem Cells: Unstable in Culture. SC) can differentiate into many different cell types, offering the potential of replacing failing cells, tissues, or even entire organs with new ones generated from the patient’s own or related donor SC (National Academy of Sciences Workshop summary. To be useful for therapy in the clinic, it would be necessary to grow and expand SCs in culture. The authors explored the proliferation of human embryonic SC ( HESC. Cultures without feeder cells (only...

5

BioMed Notes: December 2013

http://biomednotes.blogspot.com/2013_12_01_archive.html

Sunday, December 8, 2013. Levels of a common, chronic virus (TTV) reflects the immune competence of transplant recipients. TTV is a small (3.8 kb), single-stranded, transfusion transmitted DNA virus, representative of a highly diverse family of anelloviruses. Fig 5A, shown; rejecting patients plotted in red). The authors conclude that anellovirus levels might be used to monitor immune competence. Focosi et al. made a related observation following autologous stem cell transplantation. Cell 2013 Nov 21;155...

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Sunday, February 21, 2016. Skinny Genes: Human Warming and the Reverse Butterfly Effect. Obesity in humans is associated with a region around FTO. A "fat mass and obesity-associated” gene on chromosome 16. Although this is the strongest genetic association, it accounts for only a 1-2% difference in Body Mass Index (BMI) and the mechanism was unknown. Here, the investigators looked at regulator proteins binding to variants DNA sequences within the FTO. Prevented the binding of the repressor. The take-home...

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