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Function & Effectors. Welcome to the Cascales’lab. The two main projects currently developed in our team are dedicated to understand at the molecular level how the different subunits of the Type VI and Type IX secretion systems assemble these complex machineries in the bacterial cell envelope. For this we are using a combination of genetic, microscopy, biochemical and biophysical approaches. Want to know more about. What we are doing on T6SS. What we are doing on T9SS. Follow us on Twitter.

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HOME ~ LABO CNRS | cascaleslab.fr Reviews

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Function & Effectors. Welcome to the Cascales’lab. The two main projects currently developed in our team are dedicated to understand at the molecular level how the different subunits of the Type VI and Type IX secretion systems assemble these complex machineries in the bacterial cell envelope. For this we are using a combination of genetic, microscopy, biochemical and biophysical approaches. Want to know more about. What we are doing on T6SS. What we are doing on T9SS. Follow us on Twitter.

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2 people

3 collaborations

4 themes

5 introduction

6 assembly

7 regulation

8 funding

9 publications

10 news

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HOME ~ LABO CNRS | cascaleslab.fr Reviews

https://cascaleslab.fr

Function & Effectors. Welcome to the Cascales’lab. The two main projects currently developed in our team are dedicated to understand at the molecular level how the different subunits of the Type VI and Type IX secretion systems assemble these complex machineries in the bacterial cell envelope. For this we are using a combination of genetic, microscopy, biochemical and biophysical approaches. Want to know more about. What we are doing on T6SS. What we are doing on T9SS. Follow us on Twitter.

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T6SS ~ LABO CNRS

http://www.cascaleslab.fr/les-themes/t6ss

Function & Effectors. The Type VI secretion system. The main theme of research in our laboratory is dedicated to accumulate information on the Type VI secretion system. We initiated the work on this topic in January 2008 using a pathogenic strain of. The Type VI secretion system or T6SS is a multi-protein secretion machine. That have actin cross-linking (eukaryotic targets), peptidoglycan hydrolase (prokaryotic targets) or phospholipase or DNase (both eukaryote and prokaryote targets) activities. Ant...

2

T9SS ~ LABO CNRS

http://www.cascaleslab.fr/les-themes/t9ss

Function & Effectors. The Type IX secretion system. Periodontitis and gum diseases are considered as major public health concerns as roughly 36% of the world population (15-20% in industrialized countries) suffer of serious tooth tissue damages and tooth decay. The main microorganism responsible for periodontitis and gingivitis is the oral pathogenic bacterium. General mechanism of gingipain transport to the cell surface. The T9SS is poorly characterized. A number of genes, called. The generic name (por)...

3

Meetings ~ LABO CNRS

http://www.cascaleslab.fr/news/meetings

Function & Effectors. Where to meet us? 3rd French-Brazilian Symposium on Biosciences “ br.BIO.fr. 8221; (November 07th) and V Latin American Protein Society meeting (November 08-09). Rio de Janeiro (Brazil). Eric C. and Laure. Zing conference on ‘Protein Secretion in Bacteria’. EMBO Conference on ‘Bacterial morphogenesis, survival and virulence’. News & events. January 2017 25 February 2017 - 10 h 04 min. 06 November 2016 24 October 2016 - 13 h 10 min. 12 september 2016 12 September 2016 - 21 h 15 min.

4

Function & Effectors ~ LABO CNRS

http://www.cascaleslab.fr/les-themes/t6ss/function-effectors

Function & Effectors. Function & Effectors. Function & Effectors. Function of Type VI secretion systems: roles and toxins. The T6SS is considered as a versatile machinery due to its ability to inject toxins to either prokaryotic or eukaryotic cells, to mediate interbacterial interactions or pathogenesis. We have reported that the EAEC Sci-1, Sci-2. Typhimurium T6SSs have anti-bacterial activities ( Brunet. Gene In collaboration with the group of Stéphane Canaan. Phenotypes observed after injection of the.

5

People ~ LABO CNRS

http://www.cascaleslab.fr/lab/people

Function & Effectors. After graduating in the laboratory of Roland Lloubès. In 2002, I moved to Houston (Texas) for a wonderful stay in Pete Christie’s lab. Where I discovered the world of bacterial secretion systems. Back to Marseille, I launched the team on Type VI secretion. Although I love these nano-machines, I spend most of my time playing violin, listening opera, barocco violin and Glass’s Einstein on the beach, hiking to find wild orchids or kayaking or rowing in the calanques! That’s until...

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cascaleslab.fr

HOME ~ LABO CNRS

Function & Effectors. Welcome to the Cascales’lab. The two main projects currently developed in our team are dedicated to understand at the molecular level how the different subunits of the Type VI and Type IX secretion systems assemble these complex machineries in the bacterial cell envelope. For this we are using a combination of genetic, microscopy, biochemical and biophysical approaches. Want to know more about. What we are doing on T6SS. What we are doing on T9SS. Follow us on Twitter.

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