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CHO-LAB.ORG

CHO LAB - Home

Our research focus is to understand the structural dynamics and the thermodynamics of biological processes such as a autoinhibitory regulation of multidomain proteins, protein-protein interactions...

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CHO LAB - Home | cho-lab.org Reviews
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Our research focus is to understand the structural dynamics and the thermodynamics of biological processes such as a autoinhibitory regulation of multidomain proteins, protein-protein interactions...
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4 positions
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CHO LAB - Home | cho-lab.org Reviews

https://cho-lab.org

Our research focus is to understand the structural dynamics and the thermodynamics of biological processes such as a autoinhibitory regulation of multidomain proteins, protein-protein interactions...

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1

Publications - CHO LAB

http://www.cho-lab.org/publications.html

Binding mechanism of the N-terminal SH3 domain of CrkII and proline-rich motifs in cAbl. Bhatt, V.S., Zeng, D., Krieger, I., Sacchettini, J.C., Cho, J.H. Biophysical Journal, 2016, in press. Energetically Significant, Non-Native, Cooperative Interactions Within an Unfolded Protein. Sato S, Kim EY. Chindelin, H and Raleigh DP. Proc Natl. Acad. Sci. 2014, 111, 12079-12084. Palmer AG. ( Co-Corresponding Author. J Am Chem. Soc. 2013, 135, 18024-18027. Tuning protein autoinhibition by domain destabilization.

2

Kinase - CHO LAB

http://www.cho-lab.org/kinase.html

The cellular form of the Abelson leukemia tyrosine kinase, cAbl, interacts with a variety of proteins, including cell-cycle regulators, and transcription factor and signaling adaptor proteins. A tight regulation of kinase activity is critical as aberrant activation of cAbl by oncogenic fusion with the breakpoint-cluster region (Bcr-Abl) has been identified as a driving mutation of chronic myelogenous leukemia and acute lymphocytic leukemia. Proudly powered by Weebly.

3

Lab - CHO LAB

http://www.cho-lab.org/lab.html

Bruker 800 MHz arrived at College Station! Our lab uses three Bruker NMR spectrometers ( 500 MHz, 600 MHz and 800 MHz. Located in the Biomolecular NMR Center. In the Department of Biochemistry and Biophysics. Instrumentation in our lab includes PTI. QM400 fluorometer, Akta Pure FPLC, HP-HPLC, Nano Drop spectrophotomer. Proudly powered by Weebly.

4

Positions - CHO LAB

http://www.cho-lab.org/positions.html

Is available immediately in the Department of Biochemistry and Biophysics at Texas A&M University. Our lab focuses on understanding (1) self-regulatory mechanism of multidomain proteins. Role of structural dynamics in regulation of protein-protein interactions. To achieve our goals, we use a multidisciplinary approach combining biophysics, biochemistry and chemical biology. Our lab mainly uses (but not limited to). As our primary research tool. We also extensively use. Proudly powered by Weebly.

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CHO LAB - Home

Our research focus is to understand the structural dynamics. Of biological processes such as a autoinhibitory regulation of multidomain proteins, protein-protein interactions and enzyme catalysis. To achieve our goal, we combine biophysical, chemical, biochemical, and molecular biology approaches. NMR spectroscopy. Is our primary tool for structural and biophysical analysis. We also extensively use other techniques including Fluorescence spectroscopy. We are also interested in protein engineering.

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