CMGCC.CCHMC.ORG

Welcome to CMGCC

Welcome to the Cincinnati Comparative Mouse Genomics Centers Consortium Website. Peter J. Stambrook. Biochemistry and Molecular Genetics. Biochemistry and Molecular Genetics. Pediatric Informatics Molecular Dev Biol. Mice models with SNPs in Plk3. CITB Mouse 129 BAC library from Research Genetics. Hypomorphic alleles (Yeast/Mouse: deletion and point mutants). Cyclin D1 aberrant splice mouse models. Low penetrance alleles of RB. Mice models with differing alleles of p16ink4a.

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Welcome to CMGCC | cmgcc.cchmc.org Reviews

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Welcome to the Cincinnati Comparative Mouse Genomics Centers Consortium Website. Peter J. Stambrook. Biochemistry and Molecular Genetics. Biochemistry and Molecular Genetics. Pediatric Informatics Molecular Dev Biol. Mice models with SNPs in Plk3. CITB Mouse 129 BAC library from Research Genetics. Hypomorphic alleles (Yeast/Mouse: deletion and point mutants). Cyclin D1 aberrant splice mouse models. Low penetrance alleles of RB. Mice models with differing alleles of p16ink4a.

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1 people

2 personnel

3 contact id

4 department

5 organization

6 peterstambrook@uc edu

7 cell biology

8 university of cincinnati

9 yolanda sanchez

10 yolanda sanchez@uc edu

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Welcome to CMGCC | cmgcc.cchmc.org Reviews

https://cmgcc.cchmc.org

Welcome to the Cincinnati Comparative Mouse Genomics Centers Consortium Website. Peter J. Stambrook. Biochemistry and Molecular Genetics. Biochemistry and Molecular Genetics. Pediatric Informatics Molecular Dev Biol. Mice models with SNPs in Plk3. CITB Mouse 129 BAC library from Research Genetics. Hypomorphic alleles (Yeast/Mouse: deletion and point mutants). Cyclin D1 aberrant splice mouse models. Low penetrance alleles of RB. Mice models with differing alleles of p16ink4a.

INTERNAL PAGES

cmgcc.cchmc.org

1

Polymorphism

https://cmgcc.cchmc.org/Polymorphism.html

Human Polymorphisms in DNA Damage and Cell Cycle Genes. Are there Functional Consequences?

2

Knudsen's Lab

https://cmgcc.cchmc.org/Knudsen.html

Erik Knudsen, Ph.D.: RB and CCND1. Current research is focused on four specific areas. As part of our efforts we have cloned the human transcript b. We have confirmed the appropriate transcript by sequencing and are presently characterizing the product for its influence on cell cycle progression, cellular transformation and over-coming the activity of the retinoblastoma tumor suppressor, RB.

3

CEG Bioinformatics Projects

https://cmgcc.cchmc.org/BioinformaticsProjects.html

Integrate data for genes, transcripts, proteins, complexes, pathways, processes (ontologies). Visualize variations in known or predicted 3-D protein structures and domains. Cell Cycle: E.g. DNA Repair: E.g. A web-accessible, gene regulatory region discovery tool. To design and annotate all the elements in a pathway and also modify existing pathways. Selector: Populates the Gene Objects. Select genes based on the Gene Ontology assignments. Selected genes are placed in the gene object tab of a palette.

4

Doetschman's Lab

https://cmgcc.cchmc.org/Doetschman.html

Tom Doetschman, Ph.D. Consultation: The Core has met twice with Dr. Knudsen to develop a targeting scheme and construct for introducing polymorphisms in the Rb gene, and it has met several times with Dr. Sanchez for developing a targeting scheme and construct for introducing polymorphisms into the Chk1 gene. Chk2: Two consultation sessions between Core personnel and Drs. Stambrook and Penner on targeting strategy have been held. Plk3: Four consultation sessions between Core personnel and Drs. Stambro...

5

Aronow's Lab

https://cmgcc.cchmc.org/Aronow.html

Bruce J. Aronow, Ph.D. The three principle systems are:. GeneServer: Information Server for Genes of High Interest to CMGCC Investigators. The goal of the geneserver database is to act as a repository and lookup source for to integrate information about genes, transcripts, proteins, and pathways. This is being approached in successive steps:. A comparative genomics cis-regulatory region discovery and analysis system. We have completed programming a web accessible database system for the detection of ...

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cmgcc.cchmc.org

Welcome to CMGCC

Welcome to the Cincinnati Comparative Mouse Genomics Centers Consortium Website. Peter J. Stambrook. Biochemistry and Molecular Genetics. Biochemistry and Molecular Genetics. Pediatric Informatics Molecular Dev Biol. Mice models with SNPs in Plk3. CITB Mouse 129 BAC library from Research Genetics. Hypomorphic alleles (Yeast/Mouse: deletion and point mutants). Cyclin D1 aberrant splice mouse models. Low penetrance alleles of RB. Mice models with differing alleles of p16ink4a.

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