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Consortium for TCR-mediated Regulation. And Oncogenesis in Lymphomas of T-cells. Email : Prof. Dr. Hansmann. To assess the capacity of mature T cells to become oncogenetically transformed we overexpressed different T-cell (proto-)oncogenes in mature T cells or hematopoietic stem cells/progenitor cells (HSC/HPC). We found that transduced HSC/HPC readily induced T-cell leukemia/lymphoma in mice. However, mature T-cell receptor (TCR) polyclonal T cells could not be transformed. T-cell prolymphocytic leukemi...

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Consortium for TCR-mediated Regulation. And Oncogenesis in Lymphomas of T-cells. Email : Prof. Dr. Hansmann. To assess the capacity of mature T cells to become oncogenetically transformed we overexpressed different T-cell (proto-)oncogenes in mature T cells or hematopoietic stem cells/progenitor cells (HSC/HPC). We found that transduced HSC/HPC readily induced T-cell leukemia/lymphoma in mice. However, mature T-cell receptor (TCR) polyclonal T cells could not be transformed. T-cell prolymphocytic leukemi...

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Consortium for TCR-mediated Regulation. And Oncogenesis in Lymphomas of T-cells. Email : Prof. Dr. Hansmann. To assess the capacity of mature T cells to become oncogenetically transformed we overexpressed different T-cell (proto-)oncogenes in mature T cells or hematopoietic stem cells/progenitor cells (HSC/HPC). We found that transduced HSC/HPC readily induced T-cell leukemia/lymphoma in mice. However, mature T-cell receptor (TCR) polyclonal T cells could not be transformed. T-cell prolymphocytic leukemi...

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Control-T

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Consortium for TCR-mediated Regulation. And Oncogenesis in Lymphomas of T-cells. Email : Prof. Dr. Hansmann. Prof Dr. rer. nat. Ralf Küppers. Prof Dr. Dr. h.c. Martin-Leo Hansmann. Dr rer. nat. René Scholtysik. Dr med. Friedrike Schwartz. Identification of genetic lesions in AITL by NGS. We aim to define the landscape of genetic lesions in AITL by whole genome sequencing of AITL cases. Recurrence of lesions will be studied by analysis of a larger cohort of cases for the candidate genes.

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http://www.control-t.de/imprint.html

Consortium for TCR-mediated Regulation. And Oncogenesis in Lymphomas of T-cells. Email : Prof. Dr. Hansmann. Senkenberg Institute of Pathology. Buildung 6, Room 207). 60596 Frankfurt, Germany. E-Mail: m.l.hansmann@em.uni-frankfurt.de. Internet: http:/ www.control-t.de. 60596 Frankfurt, Germany.

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Consortium for TCR-mediated Regulation. And Oncogenesis in Lymphomas of T-cells. Email : Prof. Dr. Hansmann. CD1d-restricted peripheral T cell lymphoma in mice and humans. J Exp Med. 2016 Apr 11. Re-activation of mitochondrial apoptosis inhibits T-cell lymphoma survival and treatment resistance. Leukemia. 2016 Mar 8. An evolutionary stability perspective on oncogenesis control in mature T-cell populations. Diebner HH, Kirberg J, Roeder I. J Theor Biol. 2015 Nov 5. Mod Pathol. 2014 Mar 14. Models for matu...

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Consortium for TCR-mediated Regulation. And Oncogenesis in Lymphomas of T-cells. Email : Prof. Dr. Hansmann. Prof Dr. rer. med. Ingo Roeder. Tel: 0351 458 60 60. Dr rer. nat. Hans H. Diebner. Tel: 0351 458 6231. Dipl-Math., M.Sc. Matthias Kuhn. Tel: 0351 458 6057. Dipl-Inf. (FH) Thoralf Stange. Tel: 0351 458 6064. To achieve this objective, we formulated the following specific aims:. Applying the modeling framework developed in aim 2, we will study the molecular consequences of certain oncogenic transfor...

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Consortium for TCR-mediated Regulation. And Oncogenesis in Lymphomas of T-cells. Email : Prof. Dr. Hansmann. Our work follows two lines of investigation:. Understanding cellular mechanisms of T cell homeostasis. T cell hierarchy and the role of endogenous antigens; consequences of (partial) agonist expression on T cell hierarchy and autoimmunity. Factors (genes) relevant for homeostatic proliferation and implicated in T cell lymphoma outgrowth. Agenes et al., 2008; Moses et al., 2003.

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tclymphoma.uni-frankfurt.de

Lymphoma research group

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Senckenberg Institute of Pathology. Prof Dr. Dr. h.c. Martin-Leo Hansmann, Dr. Benjamin Rengstl, Dr. Kathrin Warner,. Dr Frederike Schmid, Christian Weiser, Dr. Sebastian Newrzela). Klinik - Universität Frankfurt. Klinik - Universität Köln - innere Medizin.

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Komplexe Systeme - Vorträge und Konferenzen

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Hans H. Diebners Vorträge, Konferenzen, Workshops, Festivals. 18 - 21. Juni 2016. Mathematical Model for Oncogenesis Control in Mature T-Cell Populations. Presented in the XXI. Wilsede Meeting 2016: "Modern Trends in Human Leukemia and Cancer.". 01 - 02. April 2016. Frankfurt am Main, Germany. 21 - 25. September 2015. Oncogenesis Control in Mature T-Cell Populations Through Competitive Exclusion. Vortrag im Rahmen des Workshops "Cancer Evolution through Space and Time". Am Max Planck Institut in Plön.

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Consortium for TCR-mediated Regulation. And Oncogenesis in Lymphomas of T-cells. Email : Prof. Dr. Hansmann. To assess the capacity of mature T cells to become oncogenetically transformed we overexpressed different T-cell (proto-)oncogenes in mature T cells or hematopoietic stem cells/progenitor cells (HSC/HPC). We found that transduced HSC/HPC readily induced T-cell leukemia/lymphoma in mice. However, mature T-cell receptor (TCR) polyclonal T cells could not be transformed. T-cell prolymphocytic leukemi...

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