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Highly targeted therapies for brain cancer

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Highly targeted therapies for brain cancer
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Highly targeted therapies for brain cancer

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Corporate Overview - Curtana Pharmaceuticals

http://www.curtanapharma.com/about-us/corporate-overview

Curtana Pharmaceuticals is a privately-held, preclinical-stage biopharmaceutical company developing first-in-class, small molecule therapeutics that are highly specific for cancer stem cells in the central nervous system for the treatment of glioblastoma multiforme (GBM) and other brain cancers. Curtana Pharmaceuticals is located in Austin, TX.

2

News Releases - Curtana Pharmaceuticals

http://www.curtanapharma.com/news/news-releases

June 1, 2016 - Curtana Pharmaceuticals Receives Top Honors at the 5th Annual Texas Life Science Forum. Nov 18, 2015 - Gary W. Pace Joins Curtana Pharmaceuticals Board of Directors. Sept 1, 2015 - Martin Simonetti Joins Curtana Board of Directors. Oct 1, 2014 - Curtana Pharmaceuticals Awarded NIH Small Business Technology Transfer Grant To Advance Glioblastoma Therapy. Aug 21, 2014 - Curtana Pharmaceuticals Awarded $7.6 Million Grant From The Cancer Prevention And Research Institute Of Texas.

3

Our Science - Curtana Pharmaceuticals

http://www.curtanapharma.com/therapeautic-approach/our-science

Transcription Factors as Drug Targets. Anti-GBM potency in biochemical, cell-based, and reporter assays. OLIG2 as a Drug Target. The conventional therapeutic approach to treating GBM, which often includes surgery, chemotherapy and radiation therapy, targets the tumor bulk, but it has limited effect on the CSCs. Following initial therapy, microenvironmental factors and activation of specific signaling pathways are able to sustain the population of remaining CSCs, allowing for tumor recurrence.

4

Careers - Curtana Pharmaceuticals

http://www.curtanapharma.com/careers

We are looking for exceptional individuals who share our passion for developing cancer therapeutics that dramatically impact and improve patients’ lives. To be considered for a role, please submit your resume to careers@curtanapharma.com. With the job title in the subject line of your email. We are an equal opportunity employer offering a competitive salary and benefits package. All applicants should be legally entitled to work for any employer in the US. Note to Employment Agencies:.

5

Focus - Curtana Pharmaceuticals

http://www.curtanapharma.com/therapeautic-approach/focus

GBMs are biologically aggressive tumors that present unique treatment challenges due to the following characteristics:. Localization of tumors in the brain. Inherent resistance to conventional therapy. Limited capacity of the brain to repair itself. Migration of malignant cells into adjacent brain tissue. The variably disrupted tumor blood supply which inhibits drug delivery. Tumor capillary leakage, resulting in an accumulation of fluid around the tumor and intracranial hypertension. Because OLIG2 is al...

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ati.utexas.edu ati.utexas.edu

Bio & Health Science | Austin Technology Incubator

http://ati.utexas.edu/current-portfolio/bio-health-sciences

ATI’s Bio/Health Sciences program focuses on human health medical devices, diagnostics, research tools, and therapeutics. Our team has deep expertise in the regulatory pathways and reimbursement landscapes that these startups have to navigate. Algorithms and associated hardware that enhance the performance of existing cardiac devices (e.g., heart failure diagnosis, pacemaker ‘tuning’). Advanced post-surgical adhesion barrier. First application: tendon repair. Verticals & Teams. West Pickle Research Center.

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Current Portfolio - Austin Technology Incubator

http://ati.utexas.edu/current-portfolio

Here's a look at our current member companies. Low-cost noise-abatement technology for marine environments. Algorithms and associated hardware that enhance the performance of existing cardiac devices (e.g., heart failure diagnosis, pacemaker ‘tuning’). Aeglea BioTherapeutics is developing novel engineered human enzyme drug candidates that selectively target and inactivate amino acids required in tumorigenesis. Advanced post-surgical adhesion barrier. First application: tendon repair. Decentralized, scala...

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News | IC² Institute, The University of Texas at Austin | Innovation, Creativity, Capital

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The University of Texas at Austin. Bureau of Business Research. ICTPI: International Conference on Technology Policy and Innovation. Converting Technology to Wealth: Technology Transfer Training. FASTFORWARD Small Business Training. Maestría en Comercialización (MCCT Mexico). UT Austin Portugal CoLab. Austin Technology Incubator “graduates” raise $220M. August 24, 2016. The Austin Technology Incubator. Wells Fargo is the lead sponsor for the graduation event, which will open with a cocktail reception to ...

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Highly Targeted Therapies For Brain Cancer. Curtana Pharmaceuticals is developing highly targeted therapies for the treatment of brain cancer, including glioblastoma in adults and pediatric high grade glioma in children. Patients typically are treated with surgery, radiation, and chemotherapy. Unfortunately, current treatments offer little hope of significantly prolonging a patient’s life. First-in-class, highly targeted, potent, small molecule inhibitor of Olig2 with excellent drug-like properties.

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