digital-development.org

Digital Development

Cell Lineage Differentiation over Time, Space and Genome. Elucidating how the genome shapes the regulatory landscape of cell lineage differentiation is critical for our understanding of development and. Cell fate engineering. However, experimental data are scarce on. Lineage analysis with high temporal and spatial resolution. We have recently conducted a systematic study of lineage differentiation in the. Du, Z, Santella, A, He, F, Tiongson, M, and Bao, Z. (2014). De novo inference of systems-lev...Du, Z...

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Digital Development | digital-development.org Reviews

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Cell Lineage Differentiation over Time, Space and Genome. Elucidating how the genome shapes the regulatory landscape of cell lineage differentiation is critical for our understanding of development and. Cell fate engineering. However, experimental data are scarce on. Lineage analysis with high temporal and spatial resolution. We have recently conducted a systematic study of lineage differentiation in the. Du, Z, Santella, A, He, F, Tiongson, M, and Bao, Z. (2014). De novo inference of systems-lev...Du, Z...

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Digital Development | digital-development.org Reviews

https://digital-development.org

Cell Lineage Differentiation over Time, Space and Genome. Elucidating how the genome shapes the regulatory landscape of cell lineage differentiation is critical for our understanding of development and. Cell fate engineering. However, experimental data are scarce on. Lineage analysis with high temporal and spatial resolution. We have recently conducted a systematic study of lineage differentiation in the. Du, Z, Santella, A, He, F, Tiongson, M, and Bao, Z. (2014). De novo inference of systems-lev...Du, Z...

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digital-development.org

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Digital Development

http://www.digital-development.org/browse.html

Perturbation Phenotype Summary by Gene. This database includes the phenotypic data of 1,368 embryos under 204 gene perturbations. Phenotypes are represented by tissue-marker expression in single cells mapped onto the cell lineage of each perturbed embryo and are organized by genes. Cell Fate Change Phenotypes. A summary of phenotype per gene is also provided in the form of a cell lineage. Changes to each fate marker are merged to detect perturbed founder fates (marked with blue in the cell lineage)&#...

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Digital Development

http://www.digital-development.org/index.html

Cell Lineage Differentiation over Time, Space and Genome. Elucidating how the genome shapes the regulatory landscape of cell lineage differentiation is critical for our understanding of development and. Cell fate engineering. However, experimental data are scarce on. Lineage analysis with high temporal and spatial resolution. We have recently conducted a systematic study of lineage differentiation in the. Du, Z, Santella, A, He, F, Tiongson, M, and Bao, Z. (2014). De novo inference of systems-lev...Du, Z...

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Digital Development

http://www.digital-development.org/intro.html

I Systematic phenotypic analysis of C. elegans. Lineage differentiation over time, space and genome. RNAi screening of 1,061 embryonic essential genes identified 204 developmental regulatory genes with broad molecular and cellular functions. Three tissue-specific markers were used to assay lineage differentiation. Systematic lineage tracing and marker expression mapping for 1,368 embryos with embryonic lethal phenotypes. II Systematic Perturbation of Lineage Differentiation. 4,657 clonal fate changes.

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Digital Development

http://www.digital-development.org/about.html

The Digital Development database website was designed and programmed by members of the Bao lab including Anthony Santella, Zhuo Du and Ismar Kovacevich. The database was integrated with WORMATLAS. By David Hall and Laura Herndon. For questions, bug reports etc. contact: Anthony Santella, santella (at) mskcc.org. At the Memorial Sloan Kettering Cancer Center is interested in developmental systems biology. In particular, we use. Alumni site: Zhuo Du. Automated cell tracking and lineaging. Santella A, Du Z,...

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Digital Development

http://www.digital-development.org/download.html

The links below provide underlying data and results in formats suitable for further processing. Excel spreadsheet of 204 analyzed genes. Excel spreadsheet contains each gene analyzed and annotation regarding the gene's general functional class. Zip file of cell lineages and expression data. Zip file of cell lineages and expression data for wild type embryos. Individual files formated as above. Excel spreadsheet of all phenotypic changes. 1/red: gain of pharynx fate. 1/green: loss of pharynx fate. Global ...

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digital-development.org

Digital Development

Cell Lineage Differentiation over Time, Space and Genome. Elucidating how the genome shapes the regulatory landscape of cell lineage differentiation is critical for our understanding of development and. Cell fate engineering. However, experimental data are scarce on. Lineage analysis with high temporal and spatial resolution. We have recently conducted a systematic study of lineage differentiation in the. Du, Z, Santella, A, He, F, Tiongson, M, and Bao, Z. (2014). De novo inference of systems-lev...Du, Z...

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