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Discover the Role of Phosphodiesterase 4 (PDE4) in Autoimmune Disease

PDE4 Is a Key Enzyme Involved in Modulating Productionof Inflammatory Mediators by Immune Cells Phosphodiesterase 4 (PDE4) is the predominant enzyme that degrades the second messenger cAMP in many immune cells, including eosinophils, neutrophils, macrophages, T cells, and monocytes. Proinflammatory mediators released by those cells lead to activation of and tissue infiltration by other immune …

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Discover the Role of Phosphodiesterase 4 (PDE4) in Autoimmune Disease | discoverpde4.com Reviews
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PDE4 Is a Key Enzyme Involved in Modulating Productionof Inflammatory Mediators by Immune Cells Phosphodiesterase 4 (PDE4) is the predominant enzyme that degrades the second messenger cAMP in many immune cells, including eosinophils, neutrophils, macrophages, T cells, and monocytes. Proinflammatory mediators released by those cells lead to activation of and tissue infiltration by other immune &hellip;
<META>
KEYWORDS
1 pde4 and
2 psoriasis
3 frequently asked questions
4 psoriatic arthritis
5 pde4's role in
6 regulating inflammation
7 intracellular mechanisms
8 the camp/pka pathway
9 pde4 scientific resources
10 interleukin il 17
CONTENT
Page content here
KEYWORDS ON
PAGE
pde4 and,psoriasis,frequently asked questions,psoriatic arthritis,pde4's role in,regulating inflammation,intracellular mechanisms,the camp/pka pathway,pde4 scientific resources,interleukin il 17,and psoriatic arthritis,glossary,camp,enthesitis,interferons
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Discover the Role of Phosphodiesterase 4 (PDE4) in Autoimmune Disease | discoverpde4.com Reviews

https://discoverpde4.com

PDE4 Is a Key Enzyme Involved in Modulating Productionof Inflammatory Mediators by Immune Cells Phosphodiesterase 4 (PDE4) is the predominant enzyme that degrades the second messenger cAMP in many immune cells, including eosinophils, neutrophils, macrophages, T cells, and monocytes. Proinflammatory mediators released by those cells lead to activation of and tissue infiltration by other immune &hellip;

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1

Psoriasis and psoriatic arthritis are linked to proinflammatory cytokines

http://www.discoverpde4.com/aberrant-inflammation.html

Aberrant Inflammation in Psoriatic Disease. Psoriatic disease is associated with aberrant inflammation and the production of proinflammatory mediators. Current research regarding the immunopathogenesis of psoriasis supports the theory of a dysregulated immune system governed by proinflammatory cytokines, including TNF-α, IL-17, IL-23, and other cytokines. Increased levels of proinflammatory mediators are found in lesions and synovium of patients with psoriatic disease. When inflammatory dysregulation act...

2

PDE4 could promote inflammation in psoriasis and arthritis

http://www.discoverpde4.com/role-of-pde4.html

PDE4 Plays a Major Role in Regulating Immune Cells'. Production of Mediators of Inflammation. Such as TNF-α, IL-17, and IFN-γ. By breaking down cAMP, PDE4 indirectly decreases the production of anti-inflammatory mediators such as IL-10. PDE4 has been implicated in a number of inflammatory diseases. Including psoriasis, psoriatic arthritis, and ankylosing spondylitis. PDE4 Is the Predominant Phosphodiesterase. Active in Immune Cells. Once activated, immune cells release proinflammatory mediators that can ...

3

References

http://www.discoverpde4.com/references.html

Bäumer W, Hoppmann J, Rundfeldt C, Kietzmann M. Highly selective phosphodiesterase 4 inhibitors for the treatment of allergic skin diseases and psoriasis. Inflamm Allergy Drug Targets. Joshi R. Immunopathogenesis of psoriasis. Indian J Dermatol Venereol Leprol. Souness JE, Griffin M, Maslen C, et al. Evidence that cyclic AMP phosphodiesterase inhibitors suppress TNF alpha generation from human monocytes by interacting with a 'low‑affinity' phosphodiesterase 4 conformer. Am J Respir Cell Mol Biol. Jimenez...

4

Frequently Asked Questions about the Role of PDE4 in Psoriasis and Psoriatic Arthritis

http://www.discoverpde4.com/pde4-psoriasis-and-psoriatic-arthritis-faq.html

Frequently Asked Questions (FAQ): PDE4, Psoriasis, and Psoriatic Arthritis. Phosphodiesterase 4 (PDE4) is thought to be a key intracellular enzyme involved in regulating the production of inflammatory mediators. In nonclinical models, the degradation of cAMP also decreases the production of anti‑inflammatory mediators such as IL‑10. How is PDE4 involved in immune system disorders? PDE4 is believed to promote production of pro‑inflammatory mediators. If these responses are not properly regulated by homeos...

5

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PDE4 and Psoriatic Arthritis. Role of PDE4 in Psoriatic Arthritis. PDE4's Role in Regulating Inflammation. Aberrant Inflammation in Psoriatic Disease. PDE4 and Pro-Inflammatory Mediators. CAMP Transmits Messages Within the Cell. Frequently Asked Questions (FAQ): PDE4, Psoriasis, and Psoriatic Arthritis. Receive e-mail announcements regarding site updates and real-world data on the burden of psoriasis, psoriatic arthritis, or ankylosing spondylitis. See PDE4's Role in Autoimmune Disease. And Terms of Use.

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Discover the Unmet Need in Psoriatic Arthritis | Discover PSA

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PsA &dash; Distinct & Complex. Burden & Cost of PsA. Unmet Need in PsA. Role of PDE4 in PsA. Discover the Unmet Need in Psoriatic Arthritis. The journey of patients with psoriatic arthritis is all too often characterized by therapy switch, augmentation, and discontinuation underscoring the need for new treatment options. PsA Patients Experience Changes in Treatment Including Discontinuation, Switching, and Augmentation. The reasons for therapy change were not reported. From 2003 to 2011, a total of 5,604...

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Psoriatic Arthritis (PsA) Places a High Burden on Patient Quality of Life, Productivity, and Healthcare Resources | Discover PSA

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PsA &dash; Distinct & Complex. Burden & Cost of PsA. Unmet Need in PsA. Role of PDE4 in PsA. Psoriatic Arthritis (PsA) Places a High Burden on Patient Quality of Life, Productivity, and Healthcare Resources. Psoriatic Arthritis Negatively Effects Patients' Psychological and Psychosocial Functioning and Daily Living Activities. Psoriatic arthritis places a high burden on patient quality of life (QoL), productivity (indirect costs), and healthcare resources (direct costs). Defined as time away from work an...

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Reference List | Discover PSA

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PsA &dash; Distinct & Complex. Burden & Cost of PsA. Unmet Need in PsA. Role of PDE4 in PsA. Husted JA, Tom BD, Farewell VT, et al. A longitudinal study of the effect of disease activity and clinical damage on physical function over the course of psoriatic arthritis: Does the effect change over time? Kane D, Stafford L, Bresnihan B, FitzGerald O. A prospective, clinical and radiological study of early psoriatic arthritis: an early synovitis clinic experience. J Am Acad Dermatol. 2008 Jul;35(7):1431 1433.

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Site-map | Discover PSA

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PsA &dash; Distinct & Complex. Burden & Cost of PsA. Unmet Need in PsA. Role of PDE4 in PsA. Psoriatic Arthritis (PsA): A Distinct, Complex Disease. Psoriatic Arthritis (PsA) Places a High Burden on Patient Quality of Life, Productivity, and Healthcare Resources. Discover the Unmet Need in Psoriatic Arthritis. Discover the Role of PDE4 in Psoriatic Arthritis. Receive Email Updates and Additional Information. Sign-up Now ». And Its Role in PsA. Last Updated: December 16, 2013.

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Discover the Role of PDE4 in Psoriatic Arthritis | Discover PSA

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PsA &dash; Distinct & Complex. Burden & Cost of PsA. Unmet Need in PsA. Role of PDE4 in PsA. Discover the Role of PDE4 in Psoriatic Arthritis. Research is focused on understanding the broader inflammatory processes at work and the intracellular signaling pathways that are involved in the overproduction of a network of proinflammatory mediators. Inflammation is Generally Viewed as Part of the Body's Normal Response to Injury or Infection. And decreases production of anti-inflammatory mediators (eg, IL-10).

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Discover the Role of Phosphodiesterase 4 (PDE4) in Autoimmune Disease

Comorbidities Associated with Psoriasis. Take the MAPP Quiz. Role of PDE4 in Psoriatic Arthritis. Comorbidities Associated with Psoriatic Arthritis. Aberrant Inflammation in Psoriatic Disease. PDE4 and Pro-Inflammatory Mediators. CAMP Transmits Messages Within the Cell. Discover the Role of PDE4 in Psoriasis and Psoriatic Arthritis. PDE4 plays an important role in the chronic inflammation associated with the development of skin symptoms in psoriasis. Learn More ». Learn More ». Evidence suggests that cAM...

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