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DNA Replication and Human Disease

At least 5 trillion cell divisions are required for a fertilized egg to develop into an adult human, resulting in the production of more than 20 trillion meters of DNA! And yet, with only two exceptions, the genome is replicated once and only once each time a cell divides. How is this feat accomplished? What happens when errors occur? For additional information on this subject, chapters from the out of print CSHL Press monograph DNA Replication in Eukaryotic Cells. Can be downloaded here.

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DNA Replication and Human Disease | dnareplication.cshl.edu Reviews
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At least 5 trillion cell divisions are required for a fertilized egg to develop into an adult human, resulting in the production of more than 20 trillion meters of DNA! And yet, with only two exceptions, the genome is replicated once and only once each time a cell divides. How is this feat accomplished? What happens when errors occur? For additional information on this subject, chapters from the out of print CSHL Press monograph DNA Replication in Eukaryotic Cells. Can be downloaded here.
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DNA Replication and Human Disease | dnareplication.cshl.edu Reviews

https://dnareplication.cshl.edu

At least 5 trillion cell divisions are required for a fertilized egg to develop into an adult human, resulting in the production of more than 20 trillion meters of DNA! And yet, with only two exceptions, the genome is replicated once and only once each time a cell divides. How is this feat accomplished? What happens when errors occur? For additional information on this subject, chapters from the out of print CSHL Press monograph DNA Replication in Eukaryotic Cells. Can be downloaded here.

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Answers to common questions regarding dnareplication.cshl.edu. Users of this site should review the CSHL Press Privacy Policy. Disclaimer for all content on this site. The dnareplication.cshl.edu. Easily send all of your questions and comments through our contact form. Purchase the Book Online. Buy the book, DNA Replication and Human Disease. Directly from Cold Spring Harbor Laboratory Press Web site. Click here to visit the CSHL Press Web site.

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Click on the highlighted text below to see the figure. Figure 1-1. Initiation of DNA replication. Figure 1-2. DNA relication forks. Figure 2-1. The replicon model. Figure 2-2. Functional elements in yeast replicators. Figure 2-3. Metazoan replication origins. Figure 2-4. Sequence features of metazoan replicators. Figure 3-1. Speculative model of pre-RC formation. Figure 4-1. Mechanism of helicase activation. Figure 5-1. Eukaryotic DNA replication fork. Figure 5-3. Replicative DNA polymerase model. Figure...

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About the Editor and Contributors

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Melvin L. DePhamphilis. Is the Section Chief and member of the Senior Biomedical Research Service, National Institute of Child Health and Human Development, Bethesda, MD. His research group focuses on the problem of initiation of DNA replication in mammals, and the regulation of DNA replication and gene expression at the beginning of mammalian development. Aladjem, Mirit I.,. Almouzni, Geneviève,. Section de Recherche, Institute Curie, CNRS, Paris, France. Araki, Hiroyuki,. Aravind, L.,. Bartek, Jiri,.

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DNA Replication in Eukaryotic Cells Menu

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DNA Replication in Eukaryotic Cells. Concepts, Part I. Mechanisms for Replicating RNA. Origins of DNA Replication. Roles of Transcription Factors in DNA Replication. Roles of Nuclear Structure in DNA Replication. Mechanisms for Priming DNA Synthesis. Mechanisms for Completing DNA Replication. Fidelity of DNA Replication. Concepts, Part II. DNA Excision Repair Pathways. Chromatin Structure and DNA Replication: Implications for Transcriptional Activity. Roles of Phosphorylation in DNA Replication.

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DNA Replication and Human Disease

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Submit a Book Proposal. Request an Exam Copy. Classic Titles on Sale. Type two or more letters for suggestions):. Cold Spring Harbor Laboratory History. Human Biology and Disease. Origin and Evolution of Life. DNA Replication and Human Disease. Cold Spring Harbor Monograph Series 47). Cold Spring Harbor Monograph Series. Edited by Melvin L. DePamphilis,. National Institutes of Health. Http:/ dnareplication.cshl.edu. DNA Replication in Eukaryotic Cells. View sample pages from the book here. Peter M.J&...

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DNA Replication and Human Disease

At least 5 trillion cell divisions are required for a fertilized egg to develop into an adult human, resulting in the production of more than 20 trillion meters of DNA! And yet, with only two exceptions, the genome is replicated once and only once each time a cell divides. How is this feat accomplished? What happens when errors occur? For additional information on this subject, chapters from the out of print CSHL Press monograph DNA Replication in Eukaryotic Cells. Can be downloaded here.

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