drygin.ccbr.utoronto.ca

DRYGIN - Data Repository of Yeast Genetic INteractions

DRYGIN is a database of quantitative genetic interactions of S. cerevisiae. Derived from the SGA double-mutant arrays conducted in Boone lab. At Terrence Donnelly Centre for Cellular and Biochemical Research. Total SGA genetic interactions in DRYGIN: 5,482,948. Total genes screened: 1,711 query (1,672 ORFs) X 3,885 array (3,885 ORFs). 2010-02-10: The database was updated with the latest values from Costanzo et al., 2010. 2010-11-18: The clc1Δ. Screen was removed because an allele discrepancy was noticed.

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DRYGIN - Data Repository of Yeast Genetic INteractions | drygin.ccbr.utoronto.ca Reviews

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DRYGIN is a database of quantitative genetic interactions of S. cerevisiae. Derived from the SGA double-mutant arrays conducted in Boone lab. At Terrence Donnelly Centre for Cellular and Biochemical Research. Total SGA genetic interactions in DRYGIN: 5,482,948. Total genes screened: 1,711 query (1,672 ORFs) X 3,885 array (3,885 ORFs). 2010-02-10: The database was updated with the latest values from Costanzo et al., 2010. 2010-11-18: The clc1Δ. Screen was removed because an allele discrepancy was noticed.

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DRYGIN - Data Repository of Yeast Genetic INteractions | drygin.ccbr.utoronto.ca Reviews

https://drygin.ccbr.utoronto.ca

DRYGIN is a database of quantitative genetic interactions of S. cerevisiae. Derived from the SGA double-mutant arrays conducted in Boone lab. At Terrence Donnelly Centre for Cellular and Biochemical Research. Total SGA genetic interactions in DRYGIN: 5,482,948. Total genes screened: 1,711 query (1,672 ORFs) X 3,885 array (3,885 ORFs). 2010-02-10: The database was updated with the latest values from Costanzo et al., 2010. 2010-11-18: The clc1Δ. Screen was removed because an allele discrepancy was noticed.

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drygin.ccbr.utoronto.ca

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DRYGIN - Data Repository of Yeast Genetic INteractions

http://drygin.ccbr.utoronto.ca/index.html

DRYGIN is a database of quantitative genetic interactions of S. cerevisiae. Derived from the SGA double-mutant arrays conducted in Boone lab. At Terrence Donnelly Centre for Cellular and Biochemical Research. Total SGA genetic interactions in DRYGIN: 5,482,948. Total genes screened: 1,711 query (1,672 ORFs) X 3,885 array (3,885 ORFs). 2010-02-10: The database was updated with the latest values from Costanzo et al., 2010. 2010-11-18: The clc1Δ. Screen was removed because an allele discrepancy was noticed.

2

DRYGIN - Search SGA by genes

http://drygin.ccbr.utoronto.ca/VISUALIZATION/Interactions.html

Retrieve SGA genetic interactions involving one or more query genes using gene names or orfs. Download interactions or visualize network or clustergram, with genes color-coded according to functional annotations. Significant genetic interactions ( ε 0.08, p-val 0.05). Not significant genetic interactions. Significant genetic interaction profile correlations ( r. Not significant genetic interaction profile correlations. At CCBR, University of Toronto.

3

DRYGIN - Documentation

http://drygin.ccbr.utoronto.ca/DRYGIN_help.html

DRYGIN database questions/suggestions: Matej Usaj. Or Judice L.Y. Koh. SGA project and data: Michael Costanzo. DRYGIN database: Koh JLY, Ding H, Costanzo M, Baryshnikova A, Toufighi K, Bader GD, Myers CL, Andrews BJ, Boone C. "DRYGIN: a database of quantitative genetic interaction networks in yeast", Nucleic Acids Research, 2010, 38:D502-D507. SGA dataset: Costanzo M, Baryshnikova A, Bellay J, et al., "The genetic landscape of a cell", Science, 2010, 327:425-431.

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DRYGIN - Download SGA interactions

http://drygin.ccbr.utoronto.ca/DOWNLOAD/Download.html

Sgadata costanzo2009 intermediateCutoff 101120.txt.gz. The file contains the SGA genetic interaction dataset with an intermediate cutoff applied ( ε 0.08, p-value. Genetic interaction score (ε). Sgadata costanzo2010 correlations.txt.gz. For additional data files in different formats and/or at different cutoffs, refer to the Costanzo et al. Supplementary website: drygin.ccbr.utoronto.ca/ costanzo2009/. List of query genes:. Sgadata costanzo2009 query list 101120.txt. List of array genes:.

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ExPASy - ProtParam tool. タンパク質情報 (MW, pI など). PrDOS - Protein disorder prediction server. NPS@ : CONSENSUS secondary structure prediction. Multiple protein alignment and 3D-alignment. Structural Life Science Data Cloud. The RCSB Protein Data Bank. BMRB - Biological Magnetic Resonance Bank. Nat Struct. Mol. Biol. Proc Natl. Acad. Sci. USA. 京都産業大学総合生命科学部生命システム学科遠藤研究室.

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Paper of the Week. Interested applicants to the lab should check out opportunities for external funding, below. Dr. Downey will assist lab members and prospective applicants in applying for funding! Colony PCR for Yeast. Excellent resource maintained by Mike Tyers’ group at UMontreal. GO-term analysis made easy. Genetic interaction screening database from UToronto. Human gene and protein information database. Genetic and Physical Interaction Networks. Everything you wanted to know about S. cerevisiae.

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Synthetic lethality - Wikipedia, the free encyclopedia

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From Wikipedia, the free encyclopedia. Arises when a combination of mutations in two or more genes leads to cell death, whereas a mutation in only one of these genes does not, and by itself is said to be viable. In a synthetic lethal genetic screen. It is necessary to begin with a mutation that does not kill the cell, although may confer a phenotype. Schematic of basic synthetic lethality. Simultaneous mutations in gene pair confer lethality while any other combination of mutations is viable. If the comb...

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Associate Professor, Department of Physics. PhD Physics, UC Berkeley (2005). BS Physics, Mathematics, Economics, and Electrical Eng @ MIT. Phone: 617-715-4251 Lab: 617-324-7861. Jeffs research interests have ranged widely, from the current focus on ecological dynamics to his single-molecule research in graduate school with the. Before starting his own lab, Jeff was a. In the Physics Department at MIT working with the. Studying cooperation and cheating in yeast. Jeffs honors include an. Mentor of the year.

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DRYGIN - Data Repository of Yeast Genetic INteractions

DRYGIN is a database of quantitative genetic interactions of S. cerevisiae. Derived from the SGA double-mutant arrays conducted in Boone lab. At Terrence Donnelly Centre for Cellular and Biochemical Research. Total SGA genetic interactions in DRYGIN: 5,482,948. Total genes screened: 1,711 query (1,672 ORFs) X 3,885 array (3,885 ORFs). 2010-02-10: The database was updated with the latest values from Costanzo et al., 2010. 2010-11-18: The clc1Δ. Screen was removed because an allele discrepancy was noticed.

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