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Heidi Dvinge

However, mis-regulating of RNA splicing appears to be a common feature of many human diseases, including cancer. Such mis-regulated splicing can occur either directly due to mutations or other changes in the splicing machinery, or through a complex interaction of multiple factors and cellular mechanisms. Proudly powered by WordPress.

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Heidi Dvinge | dvingeresearch.org Reviews

https://dvingeresearch.org

However, mis-regulating of RNA splicing appears to be a common feature of many human diseases, including cancer. Such mis-regulated splicing can occur either directly due to mutations or other changes in the splicing machinery, or through a complex interaction of multiple factors and cellular mechanisms. Proudly powered by WordPress.

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Explore cancer splicing | Heidi Dvinge

http://www.dvingeresearch.org/explore-cancer-splicing

WARNING: The app is currently undergoing some updates, so might not work optimally. Which genes are most frequently aberrantly spliced in lung cancer? In which type of cancer is PTEN most frequently mis-spliced? Which exons are skipped within CDK10 in colorectal cancer? Is there more or less mis-splicing in kidney cancer compared to cancers from other tissues of origin? What category of alternative splicing are most affected pan-cancer? How do tumour and normal samples cluster according to splicing?

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CV | Heidi Dvinge

http://www.dvingeresearch.org/cv

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Papers | Heidi Dvinge

http://www.dvingeresearch.org/papers

Uo T, Dvinge H. Sprenger CC, Bradley RK, Nelson PS, Plymate SR. Systematic and functional characterization of novel androgen receptor variants arising from alternative splicing in the ligand-binding domain. Oncogene 2016 Oct; doi:10.1038. Kim E*, Abdel-Wahab O, Bradley RK. RNA splicing factors as oncoproteins and tumour suppressors. Nat Rev Cancer 2016 Jul;16(7):413-30 * Joint first authors. Lee SC*, Dvinge H*. Nat Med. 2016 Jun;22(6):672-8 * Joint first authors. Hickey TE, Irvine CM, Dvinge H. Ries RE, ...

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However, mis-regulating of RNA splicing appears to be a common feature of many human diseases, including cancer. Such mis-regulated splicing can occur either directly due to mutations or other changes in the splicing machinery, or through a complex interaction of multiple factors and cellular mechanisms. Proudly powered by WordPress.

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