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1 about us
2 our focus
3 innovative screening method
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5 who we are
6 the team
7 about e3x bio
8 latest news
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10 breakout labs
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Breakout Labs | E3X Bio

http://www.e3xrx.com/partners-view/breakout-labs

Founded by the Thiel Foundation in November 2011, Breakout Labs uses philanthropy to support a growing list of early-stage companies. In areas ranging from food science and biomedicine to clean energy. For many of these companies, we were the first external investor. Our program goes well beyond financial support. We also provide access to strategic mentorship and networking opportunities that enable further development for years to come. September 1, 2014. View all posts by: E3X. October 2, 2014 6:31 am.

2

Dave Morgans, Ph.D. | E3X Bio

http://www.e3xrx.com/team-view/dave-morgans

Dave Morgans, Ph.D. VP of Drug Discovery, founder. October 2, 2014 6:31 am. E3X Bio recieves Grant from Thiel Foundation’s Breakout Labs. E3x Bio is the first company with exclusive focus on inhibitors and activators of E3.

3

Paul Godowski, Ph.D. | E3X Bio

http://www.e3xrx.com/team-view/paul-godowski

Paul Godowski, Ph.D. October 2, 2014 6:31 am. E3X Bio recieves Grant from Thiel Foundation’s Breakout Labs. E3x Bio is the first company with exclusive focus on inhibitors and activators of E3.

4

Bill Harte, Ph.D. | E3X Bio

http://www.e3xrx.com/team-view/bill-harte

Bill Harte, Ph.D. VP of Technology platforms, founder. Bill has a chemistry background with over 25 years in the pharmaceutical and biotechnology industries at Bristol-Myers Squibb and Amgen. He led Discovery Technologies at Amgen running multidisciplinary teams over 4 research sites and shared chemistry technical oversight of 9 INDs in oncology, inflammation, neuroscience, and diabetes. October 2, 2014 6:31 am. E3X Bio recieves Grant from Thiel Foundation’s Breakout Labs.

5

Posts by E3X | E3X Bio

http://www.e3xrx.com/author/admin_e3x

Recent Posts by E3X. E3X Bio recieves Grant from Thiel Foundation’s Breakout Labs. E3x Bio is the first company with exclusive focus on inhibitors and activators of E3 Ubiquitin (Ub) ligases for drug discovery and development. This class of medically relevant enzymes is considered an important target for diseases ranging from cancer to neurodegeneration, but has been inaccessible to high-throughput drug screening because the current assays are cumbersome,. Recent Comments by E3X. No comments by E3X yet.

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Ub Ligases are proven to be critically. Involved in disease pathogenesis for oncology,. Inflammation and infectious disease. Is a simple, one-step assay. For inhibitors and activators. 1st in class drugs specifically. Targeted at Ubiquitin (Ub) ligases. Funding from Breakout Labs just Announced. Nedd4L E3 ligase in complex with E2/Ubiquitin. PDB code 3JW0; Dave Sheppherd, BioFocus. Lori Rafield, Ph.D. Paul Godowski, Ph.D. Dave Morgans, Ph.D. Bill Harte, Ph.D. October 2, 2014.

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