The Enzyme Function Initiative (EFI) will develop a robust sequence/structure‑based strategy for facilitating discovery of in vitro enzymatic and in vivo metabolic/physiological functions of unknown enzymes discovered in genome projects, a crucial limitation in genomic biology. This goal will be accomplished by integrating bioinformatics, structural biology, and computation with enzymology, genetics, and metabolomics.
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Welcome to EFI | EFI | enzymefunction.org Reviews
https://enzymefunction.org
The Enzyme Function Initiative (EFI) will develop a robust sequence/structure‑based strategy for facilitating discovery of in vitro enzymatic and in vivo metabolic/physiological functions of unknown enzymes discovered in genome projects, a crucial limitation in genomic biology. This goal will be accomplished by integrating bioinformatics, structural biology, and computation with enzymology, genetics, and metabolomics.
enzymefunction.org
User account | enzymefunction.org
http://www.enzymefunction.org/user
Enter your enzymefunction.org username. Enter the password that accompanies your username. Enzyme Function Initiative 1206 W. Gregory Drive Urbana, IL 61801 efi@enzymefunction.org.
Structure-guided discovery of new deaminase enzymes | enzymefunction.org
http://www.enzymefunction.org/publications/2013/12
Structure-guided discovery of new deaminase enzymes. Hitchcock DS, Fan H, Kim J, Vetting MW, Hillerich B, Seidel RD, Almo SC, Shoichet BK, Sali A, Raushel FM. (2013) JACS 135, 13927-33. PMCID: PMC3827683. Link to PubMed ». Table of Contents graphic. Structures of substrates for the enzymes related to Tm0936. Reprinted with permission from the Journal of the American Chemical Society. 2013 American Chemical Society.
Workshops | enzymefunction.org
http://www.enzymefunction.org/resources/workshops
2015 Annual ASBMB Meeting - BIOINFORMATICS and Modeling TOOLS WORKSHOP. Powerpoint Slides presented at the workshop:. Enzyme Function Initiative 1206 W. Gregory Drive Urbana, IL 61801 efi@enzymefunction.org.
Structure-based discovery of prescription drugs that interact with the norepinephrine transporter, NET | enzymefunction.org
http://www.enzymefunction.org/publications/2011/8
Structure-based discovery of prescription drugs that interact with the norepinephrine transporter, NET. Schlessinger A, Geier E, Fan H, Irwin JJ, Shoichet BK, Giacomini KM, Sali A. (2011) Proc Natl Acad Sci USA 108, 15810-5. PMCID: PMC3179104. In another example of the EFI’s early outreach efforts, Computation Core. Uptake kinetic experiment. Concentration-dependent effect of tranylcypromine on [3H]norepinephrine uptake under the same conditions as in Fig. 3. Data are expressed as the percent...
Discovery of a cytokinin deaminase | enzymefunction.org
http://www.enzymefunction.org/publications/2011/4
Discovery of a cytokinin deaminase. Goble AM, Fan H, Sali A, Raushel FM. (2011) ACS Chem Biol 6, 1036-40. PMCID: PMC3199332. An EFI example from the Computation Core. And AH Bridging Project. Showing the ability to go from sequence to function for a target from Pseudoalteromonas atlantica T6c which did not have an experimental crystal structure. Homology models and docking predicted adenine and various adenosine derivatives within the active site. The AH Bridging Project. Link to PubMed ».
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IGB Fellows Program | Carl R. Woese Institute for Genomic Biology
http://www.igb.illinois.edu/education/igb-fellows
Carl R. Woese Institute for Genomic Biology. Where Science Meets Society. Join Our Mailing List. The Carl R. Woese Institute for Genomic Biology was founded in 2003 to advance life science research and stimulate bioeconomic development in the state of Illinois. Learn more about our Institute. Learn More About the IGB ». Anticancer Discovery from Pets to People. Computing Genomes for Reproductive Health. Genomic Ecology of Global Change. Gene Networks in Neural and Developmental Plasticity. Read More Abou...
Minor Laboratory
http://krzys.med.virginia.edu/CrystUVa/index.php
List of all lab members. David Cooper, Instructor. Marcin Cymborowski, Research Assistant. Mateusz Czub, Visiting Graduate Student. Monika Grabowska, Student. Marek Grabowski, Research Scientist. Katarzyna Handing, Visiting Graduate Student. Jing Hou, Research Scientist. Cody LaRowe, Undergraduate Student. Joanna Lipowska, Visiting Graduate Student. Darryl Mason, Undergraduate Student. Dorota Matelska, Research Scholar. Ewa Niedzialkowska, Lab Specialist. Tomasz Osinski, Laboratory Specialist. Department...
EFI - Enzyme Similarity Tool
http://efi.igb.illinois.edu/efi-est
EFI - Enzyme Similarity Tool. Options for Generating Sequence Similarity Networks. What is a Sequence Similarity Network? Why use Sequence Similarity Networks? Example 1: a simple case. Example 2: multidomain proteins. Introduction to Cytoscape 3.X.X. OPTIONS FOR GENERATING SEQUENCE SIMLARITY NETWORKS. Please see our recent review in BBA Proteins for examples of EFI-EST use. Please proceed to the tutorial. Need help or have suggestions or comments? Please click here to submit.
Minor Laboratory
http://olenka.med.virginia.edu/CrystUVa/index.php
List of all lab members. David Cooper, Instructor. Marcin Cymborowski, Research Assistant. Mateusz Czub, Visiting Graduate Student. Monika Grabowska, Student. Marek Grabowski, Research Scientist. Katarzyna Handing, Visiting Graduate Student. Jing Hou, Research Scientist. Cody LaRowe, Undergraduate Student. Joanna Lipowska, Visiting Graduate Student. Darryl Mason, Undergraduate Student. Dorota Matelska, Research Scholar. Ewa Niedzialkowska, Lab Specialist. Tomasz Osinski, Laboratory Specialist. Department...
Minor Laboratory
http://iwonka.med.virginia.edu/CrystUVa/index.php
List of all lab members. Vincent Choy, Administrative Assistant. David Cooper, Instructor. Marcin Cymborowski, Research Assistant. Mateusz Czub, Visiting Graduate Student. Monika Grabowska, Student. Marek Grabowski, Research Scientist. Jing Hou, Research Scientist. Tiffany Kim, Administrative Assistant. Cody LaRowe, Undergraduate Student. Joanna Lipowska, Visiting Graduate Student. Darryl Mason, Undergraduate Student. Dorota Matelska, Research Scholar. Dylan Miks, Undergraduate Student. E-mail: wladek@iw...
Enzyme Function Initiative - Pages
http://kiemlicz.med.virginia.edu/efi
Superfamilies: Targets and Structures. Ligands - full list. What is the EFI-DB? The EFI-DB serves as the EFI’s public database of experimental data. The database stores details of all cloning, purification, and structure determination experiments, as well as the results of in vivo and in vitro analyses as they become publicly available. The information is presented in a dynamic, interactive format to allow one to quickly browse through all experimental data. Targets with structures: 209. Download and vie...
Andrej Sali Lab
http://salilab.org/our_associations.html
Bull; Lab Members. Bull; Research Positions. Bull; Directions and Maps. Bull; Lab Pages. Department of Bioengineering and Therapeutic Sciences. Department of Pharmaceutical Chemistry. Institute for Computational Health Sciences. University of California, San Francisco. National Center for Dynamic Interactome Research (NCDIR). Center for Structures of Membrane Proteins. New York Structural Genomix Research Consortium. Pharmacogenetics of Membrane Transporters. Center for Computational Proteomics Research.
Peter Kolb, junior group leader at Philipps-Universität Marburg
http://www.kolblab.org/kolb.html
Dept of Pharmaceutical Chemistry. Mail: 35032 Marburg, Germany. Packages: 35037 Marburg, Germany. After studies in Biochemistry and Theoretical Chemistry at the University of Vienna and Karolinska Institute, I did my Ph.D. in Computational Biochemistry with Amedeo Caflisch. At the University of Zurich. At the University of California, San Francisco. Which brings together more than 190 scientists from 31 European countries. In March 2015, I was awarded the "Innovation Prize in Medicinal/Pharmaceutical Che...
Babbitt Lab Links
http://babbittlab.ucsf.edu/links.html
Lab Members and Alumni. Linking Sequence and Structure. California Institute for Quantitative Biosciences (QB3). University of California San Francisco. 1700 4th Street, 5th Floor. San Francisco, CA 94158. The Enzyme Function Initiative (EFI). The EFI will develop a robust sequence/structure-based strategy for facilitating discovery of in vitro enzymatic and in vivo metabolic/physiological functions of unknown enzymes discovered in genome projects, a crucial limitation in genomic biology. The UCSF Comput...
Babbitt Lab Links
http://babbittlab.compbio.ucsf.edu/links.html
Lab Members and Alumni. Linking Sequence and Structure. California Institute for Quantitative Biosciences (QB3). University of California San Francisco. 1700 4th Street, 5th Floor. San Francisco, CA 94158. The Enzyme Function Initiative (EFI). The EFI will develop a robust sequence/structure-based strategy for facilitating discovery of in vitro enzymatic and in vivo metabolic/physiological functions of unknown enzymes discovered in genome projects, a crucial limitation in genomic biology. The UCSF Comput...
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Enzyme Supplement
Sunday, 11 September 2011. Paypal buy now button. I am selling Enzyme Product. This book is good for health. Subscribe to: Posts (Atom). Enter your email address:. Paypal buy now button. View my complete profile. Watermark template. Powered by Blogger.
Enzyme Formulations, Inc.
Register for an Account. Using Herbs with Enzymes. For over 20 years, Enzyme Formulations, Inc. has provided premium quality nutritional products to healthcare practitioners around the world. Our products are born from extensive clinical research and validated by clinical results. We do not design our products in a library. Our goal is to provide information and nutritional solutions to regain optimal health. We take a common sense approach to dietary supplementation - no mega-doses of nutrients. Groups ...
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Enzyme Function
This blog aims to improve awareness of the common functional feature of enzymes. In 2002 a theoretical examination of catalysis by soft materials. Showed that focussed surface tension forces are required for function. This conclusion seems irrefutable, but conflicts with protein crystal structures. The present blog gathers non-structural evidence supporting the 2002 study. Of course, countervailing evidence is also sought. Companion Blog - Native Proteins. My companion blog, Native Proteins. Insofar as D...
Welcome to EFI | EFI
Skip to main content. The Enzyme Function Initiative. EFI) is developing a robust sequence / structure based strategy for facilitating discovery of. Metabolic / physiological functions of unknown enzymes discovered in genome projects. More. Using bioinformatic analyses, superfamily member sequences (colored circles) are clustered into discrete groups and visualized in sequence similarity networks. Clusters are evaluated for unknown functions to aid selection of targets for the EFI pipeline. More. Approac...
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