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Phenylbutyrate (PB) は抗腫瘍効果を示す HDAC 抑制剤である。 CRL およびMDAMB453 乳癌株化細胞はPB感受性であり、MDAMB231 乳癌細胞株がPB抵抗性株であった。 RAB25 およびESRP1 はPB 感受性規定分子であったが、一方 ANKD1, ETS1, PTRF, IFI16 およびKIAA1199はPB 抵抗性分子候補であった。 RAB25 発現は IFI16およびPTRFを抑制し、ESRP1 発現はANKRD1, ETS1, および KIAA1199を抑制した。 したがって、PB 感受性は ZEB1の epigenetic 制御の下流でコントロールされることが判明した。 12288;  . 12288;   プライバシーポリシー. 169; Epigenetic Therapy Study Group.

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