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Functional Fluidics | Tools to Predict, Select, and Monitor

Advanced Blood Function Diagnostics. Functional Fluidics has developed a suite of proprietary flow based assays that measure adhesion and thrombosis in whole blood. We enable our pharmaceutical and academic partners to predict, select, and monitor a variety of emerging and established blood function therapies. Clinical Blood Function Assays. We specialize in the development and standardization of clinical blood function assays to assess individual patient response to our partners’ therapies. Blood sample...

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Functional Fluidics | Tools to Predict, Select, and Monitor | functionalfluidics.com Reviews
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Advanced Blood Function Diagnostics. Functional Fluidics has developed a suite of proprietary flow based assays that measure adhesion and thrombosis in whole blood. We enable our pharmaceutical and academic partners to predict, select, and monitor a variety of emerging and established blood function therapies. Clinical Blood Function Assays. We specialize in the development and standardization of clinical blood function assays to assess individual patient response to our partners’ therapies. Blood sample...
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Functional Fluidics | Tools to Predict, Select, and Monitor | functionalfluidics.com Reviews

https://functionalfluidics.com

Advanced Blood Function Diagnostics. Functional Fluidics has developed a suite of proprietary flow based assays that measure adhesion and thrombosis in whole blood. We enable our pharmaceutical and academic partners to predict, select, and monitor a variety of emerging and established blood function therapies. Clinical Blood Function Assays. We specialize in the development and standardization of clinical blood function assays to assess individual patient response to our partners’ therapies. Blood sample...

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1

Flow Adhesion Characterization | Functional Fluidics

http://functionalfluidics.com/assays/flow-adhesion-characterization

Adhered cells are fixed with 4% formalin and stained following an adhesion assay (FF-FA, FF-FAR, FF-FAA). Fluorescence microscopy is utilized to differentiate between and quantify specific cell populations. Clinical Applications for Blood Function Assays. February 23, 2017. Functional Fluidics Invited to Present at SCDAA Detroit Chapter Advocacy Meeting. December 1, 2016. Sevuparin Blocks Sickle Blood Cell Adhesion and Sickle-Leukocyte Rolling on Immobilized L-Selectin in a Dose Dependent Manner.

2

Flow Adhesion Avidity | Functional Fluidics

http://functionalfluidics.com/assays/flow-adhesion-avidity

Blood cells are adhered to a substrate of interest (see Flow Adhesion), followed by introduction of sequentially increased shear. Remaining adherent cells are quantified followed by a sequential increase in shear Remaining adherent cells are quantified followed by a sequential increase in shear (5, 10, and 20 dyne/cm 2), to generate an avidity adhesion index (aAI). Clinical Applications for Blood Function Assays. February 23, 2017. December 1, 2016. November 17, 2016. June 24, 2016. June 16, 2016.

3

Flow Adhesion Reverse | Functional Fluidics

http://functionalfluidics.com/assays/flow-adhesion-reverse

Blood cells are adhered to a substrate of interest (see Flow Adhesion), followed by introduction of anti-adhesive drug under flow. Remaining adherent cells are measured to generate a reverse adhesion index (rAI). Clinical Applications for Blood Function Assays. February 23, 2017. Functional Fluidics Invited to Present at SCDAA Detroit Chapter Advocacy Meeting. December 1, 2016. Sevuparin Blocks Sickle Blood Cell Adhesion and Sickle-Leukocyte Rolling on Immobilized L-Selectin in a Dose Dependent Manner.

4

Publications | Functional Fluidics

http://functionalfluidics.com/publications

Clinical Applications for Blood Function Assays. Feb 23, 2017. In this presentation to the Bioflux User Group in February 2017, Dr Hines describes our vision for clinical applications of a precise blood function assay, in particular to measure Thrombosis in pediatric ICU patients:. Sevuparin Blocks Sickle Blood Cell Adhesion and Sickle-Leukocyte Rolling on Immobilized L-Selectin in a Dose Dependent Manner. Nov 17, 2016. Jun 24, 2016. Jun 12, 2016. British Journal of Hematology. White JC, Krishnamoort...

5

Flow Thrombosis | Functional Fluidics

http://functionalfluidics.com/assays/flow-thrombosis

Blood samples (whole or isolated platelets) are pre-treated with a drug of interest, and then subjected to physiologic arterial flow across a substrate of interest. A series of photomicrographs of fluorescently labeled blood (see Figure 3) is analyzed to determine the kinetics of thrombosis formation (lag time, max rate of thrombosis, area under the curve, and maximum amplitude). Clinical Applications for Blood Function Assays. February 23, 2017. December 1, 2016. November 17, 2016. June 24, 2016.

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Advanced Blood Function Diagnostics. Functional Fluidics has developed a suite of proprietary flow based assays that measure adhesion and thrombosis in whole blood. We enable our pharmaceutical and academic partners to predict, select, and monitor a variety of emerging and established blood function therapies. Clinical Blood Function Assays. We specialize in the development and standardization of clinical blood function assays to assess individual patient response to our partners’ therapies. Blood sample...

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