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Gene Signal : Biotechnology company discovering genes involved in the regulation of angiogenesis

Gene Signal is a research and development based biotechnology company focused on discovering genes involved in the regulation of angiogenesis. Gene Signal's ophthalmic research program is pioneering targeted upstream blockade of pathological angiogenesis through the inhibition of Insulin Receptor Susbtrate 1 (IRS-1)

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Gene Signal : Biotechnology company discovering genes involved in the regulation of angiogenesis | genesignal.com Reviews

https://genesignal.com

Gene Signal is a research and development based biotechnology company focused on discovering genes involved in the regulation of angiogenesis. Gene Signal's ophthalmic research program is pioneering targeted upstream blockade of pathological angiogenesis through the inhibition of Insulin Receptor Susbtrate 1 (IRS-1)

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Gene Signal : Senior Management Team

http://www.genesignal.com/Senior_Management_Team.15.0.html

Eric Viaud, Chief Executive Officer. Salman Al-Mahmood, Chief Scientific Officer. Dr Eric Thorin, Chief Development Officer. Marta Gehring, BD&L and Chief Marketing Officer. Antoine Ferry, Chief Medical Officer. John Dickinson, Chief Corporate Development Officer.

2

Gene Signal : News on GS-101 (Aganirsen)

http://www.genesignal.com/News_on_GS-101_Aganirsen.23.0.html

News on GS-101 (Aganirsen). Corneal Neovascularisation in Graft Patients. Confirmed the association between presence of pathological corneal neovessels and increased risk of graft rejection. Stromal Neovascularisation and Corneal Graft Rejection (CGR). An avascular recipient cornea is commonly regarded as an important prognostic factor for long-term survival of a corneal graft. Corneal graft rejection is primarily a cell-mediated immune response controlled by T cells. GS-101 is an antisense oligonucleoti...

3

Gene Signal : Scientific Advisory Board

http://www.genesignal.com/Scientific_Advisory_Board.13.0.html

Prof R. Beliveau, MD, University of Quebec, Canada. Director of the Proteomic Canada project, Director of two laboratories (over 50 research workers), Professor of Medicine at the University of Quebec, Canada. Internationally recognized for his expertise in oncology, angiogenesis and Alzheimer disease. Prof M. Carrier MD, University of Montreal, Canada. Prof W.M. Chilian, MD, New Orleans University, New w Orleans, USA. Dr Benoît Dubuis, chem Ing ETH, Ph.D, Dean of School of Life Sciences, Switzerland.

4

Gene Signal : Licensing Opportunities

http://www.genesignal.com/Licensing_Opportunities.36.0.html

Gene Signal is looking to develop strategic partnerships with key industry-leading companies to facilitate the development and marketing of its current discovery stage and clinical stage drug portfolio, as well as partners to facilitate entry into the Americas. We are seeking to enter licensing agreements with key partners to either commercialize or co-develop our therapeutic portfolio. In Oncology, key indications include Kidney Cancer, Lung Cancer and Pancreatic Cancer (Proof of Concept).

5

Gene Signal : Board of Directors

http://www.genesignal.com/Board_of_Directors.14.0.html

Eric Viaud, Chairman of the Board, Cofounder and Shareholder. Salman Al-Mahmood, Member of the Board, Cofounder and Shareholder. Dr Eric Thorin, Member of the Board, Cofounder and Shareholder. Jean Pierre Decker, Member of the Board and Shareholder. Antoine Ferry, Member of the Board and Shareholder.

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Gene Signal : Biotechnology company discovering genes involved in the regulation of angiogenesis

Gene Signal is a research and development based biotechnology company focused on discovering genes involved in the regulation of angiogenesis. Gene Signal's ophthalmic research program is pioneering targeted upstream blockade of pathological angiogenesis through the inhibition of Insulin Receptor Substrate 1 (IRS-1). Ldquo;Topical Aganirsen produces a highly significant regression of corneal neovascularization”. Cursiefen C., Ophthalmology. Cloutier F. Invest Ophthalmol,. Vis Sci. 2012 Mar 9 ;.

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