guttmanlab.caltech.edu
The Guttman Lab for lncRNA BiologyOur lab aims to understand how large ncRNAs control gene expression programs and cell state decisions
http://guttmanlab.caltech.edu/
Our lab aims to understand how large ncRNAs control gene expression programs and cell state decisions
http://guttmanlab.caltech.edu/
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The Guttman Lab for lncRNA Biology | guttmanlab.caltech.edu Reviews
https://guttmanlab.caltech.edu
Our lab aims to understand how large ncRNAs control gene expression programs and cell state decisions
guttmanlab.caltech.edu
The Guttman Lab for lncRNA Biology | Publications
http://www.guttmanlab.caltech.edu/publications.php
Chen CK, Blanco M, Jackson C, Aznauryan E, Ollikainen N, Surka C., Chow A, Cerase A, McDonel P, Guttman M (2016). Xist recruits the X chromosome to the nuclear lamina to enable chromosome-wide silencing. Patil DP, Chen CK, Pickering BF, Chow A, Jackson C, Guttman M, Jaffrey SR (2016). m6A RNA methylation promotes XIST-mediated transcriptional repression. Doi: doi:10.1038/nmeth.3810. J Am Med Inform Assoc. McHugh CA, Chen CK, Chow A, Surka CF, Tran C, McDonel P, Pandya-Jones A, Blanco MR, Burghard C, Mora...
The Guttman Lab for lncRNA Biology | RNA Antisense Purification
http://www.guttmanlab.caltech.edu/protocols.php
RNA Antisense Purification followed by DNA-Sequencing is a method to map the genomic DNA target sites of a given lncRNA. We designed RAP to enable specific purification of chromatin associated with a target lncRNA, achieve high resolution mapping of the associated DNA target sites upon sequencing of the captured DNA, and robustly capture any lncRNA with minimal optimization. RAP was developed by Jesse Engreitz. With help from Patrick McDonel, Alex Shishkin, Klara Sirokman, and Christine Surka. RNAtag-Seq...
The Guttman Lab for lncRNA Biology | Software
http://www.guttmanlab.caltech.edu/software.php
RAP Probe Designer Tool. A tool for designing capture or control probes for use in the RAP assay. This tool will allow you to design probes for a single RNA or batch across many RNAs as well as layout the probes on a custom microarray and optimize primer sequences at the ends of each probeset for selective amplification from complex synthesis pools. For a full description of the probe design process, see the RAP protocol. Designer tool quick guide. Download the RAP Designer Program.
The Guttman Lab for Large ncRNA Biology | Lab Members
http://www.guttmanlab.caltech.edu/lab.php
Mitchell Guttman, PhD. Amy Chow, PhD. Patrick McDonel, PhD. Ward G. Walkup IV, PhD. Mario Blanco, PhD. Graduate Student, Guttman Lab/Rothenberg Lab. Colleen McHugh, PhD. Noah Ollikainen, PhD.
The Guttman Lab for lncRNA Biology | Mitch Guttman
http://www.guttmanlab.caltech.edu/guttman.php
Is an Assistant Professor. In the Division of Biology. At the California Institute of Technology. His previous work explored unknown regions of the genome, identifying genes that do not produce proteins but do function in other important ways. His research has defined a new class of players in the genome and shed light on how they work. Guttman described a new class of genes called lincRNAs. Guttman's work bridges experimental and computational aspects of biological research. Guttman has also published s...
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Systems Biology at Caltech - Faculty
http://www.sysbio.caltech.edu/people/index.html
Professor of Biology, Bioengineering and Applied Physics; Bren Scholar; Investigator, Howard Hughes Medical Institute. Biophysics; biocomputing; gene regulation networks and variation in living cells. Norman Chandler Professor of Cell Biology. Genetic Regulatory Network underlying embryonic development in sea urchins. Assistant Professor of Biology. Systems biology, signaling pathways, robustness, biomaterial. Assistant Professor of Chemistry. Single cell systems biology. Assistant Professor of Biology.
Biology Option - Faculty
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Seymour Benzer Professor of Biology; Investigator, Howard Hughes Medical Institute Biology and Biological Engineering. The Neurobiology of Emotional Behavior. Assistant Professor of Biology. Non-coding RNAs: Study of natural functions of non-coding RNAs in the cell and programming of RNA pathways for new functions in vivo. Non-coding RNAs as determinants of epigenetic states. The link between RNA- and chromatin-based epigenetic mechanisms. President Emeritus; Robert Andrews Millikan Professor of Biology.
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The Guttman Lab for lncRNA Biology
The presence of thousands of functional large non-coding RNAs (lncRNAs) in the mammalian genome represents a missing component in our understanding of genome regulation. Our lab aims to understand how lncRNAs control gene expression programs and cell state decisions in the context of mouse embryonic stem cells. We are an integrated team of experimental and computational biologists who work together to address these questions.
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