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GWA Test Driver - Overview

Genome-wide association studies in which the association of clinically relevant phenotypes (e.g., obesity, diabetes, lupus, pulmonary hypertension, etc.) with many (e.g., 1 million) single-nucleotide polymorphisms (SNPs) is perhaps the largest current wave in human genetic research. For investigators to be part of this wave, they need to answer key questions to their satisfaction and that of grant reviewers. Such questions include:. How many subjects do I need to study? We have downloaded a number of rep...

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GWA Test Driver - Overview | gwatestdriver.ssg.uab.edu Reviews
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Genome-wide association studies in which the association of clinically relevant phenotypes (e.g., obesity, diabetes, lupus, pulmonary hypertension, etc.) with many (e.g., 1 million) single-nucleotide polymorphisms (SNPs) is perhaps the largest current wave in human genetic research. For investigators to be part of this wave, they need to answer key questions to their satisfaction and that of grant reviewers. Such questions include:. How many subjects do I need to study? We have downloaded a number of rep...
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GWA Test Driver - Overview | gwatestdriver.ssg.uab.edu Reviews

https://gwatestdriver.ssg.uab.edu

Genome-wide association studies in which the association of clinically relevant phenotypes (e.g., obesity, diabetes, lupus, pulmonary hypertension, etc.) with many (e.g., 1 million) single-nucleotide polymorphisms (SNPs) is perhaps the largest current wave in human genetic research. For investigators to be part of this wave, they need to answer key questions to their satisfaction and that of grant reviewers. Such questions include:. How many subjects do I need to study? We have downloaded a number of rep...

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1

GWA Test Driver - Other Genetic Power Software

http://gwatestdriver.ssg.uab.edu/software.jsp

Other Genetic Power Software. PGA: Power for Genetic Association Analyses. Available at: http:/ dceg.cancer.gov/bb/tools/pga. Reference: Menashe I., Rosenberg P.S., and Chen B.E. (2008) PGA: Power calculator for case-control genetic association analyses. BMC Genetics, 9:36. Http:/ linkage.rockefeller.edu/pawe3d/. Contact: pawe3d@linkage.rockefeller.edu. Http:/ statgen.iop.kcl.ac.uk/gpc/. Purcell S, Cherny SS, Sham PC. Gap: Genetic analysis package, CRAN. Power Calculator for Two Stage Association Studies.

2

GWA Test Driver - Real Data

http://gwatestdriver.ssg.uab.edu/realdata.html

Please view summary report for dataset of interest. A genome-wide scan for common genetic variants with a large influence on warfarin maintenance dose. For more information about these data, click here. Genome-wide combined case-control study of rheumatoid arthritis in the NARAC and EIRA datasets. For more information about these data, click here. Multiple Genetic Loci for Bone Mineral Density and Fractures - Hip. For more information about these data, click here. In this study a quantitative trait analy...

3

GWA Test Driver - Simulated Data

http://gwatestdriver.ssg.uab.edu/simulateddata.html

Genomewide p-values are simulated as a mixture of Uniform distribution (for SNPs with no effect) and Beta distribution (for SNPs with true effects) with parameters α and β. Please select dataset of interest. In these simulated data for 2000 individuals, we assumed 99% of genome-wide SNPs to be non-causal SNPs (i.e. under Null hypothesis with heritability=0) with their association p-values Uniformly distributed and remaining 1% SNPs to be causal SNPs with their heritability between 0 and 0.1 a...In these ...

4

GWA Test Driver - Overview

http://gwatestdriver.ssg.uab.edu/index.jsp

Genome-wide association studies in which the association of clinically relevant phenotypes (e.g., obesity, diabetes, lupus, pulmonary hypertension, etc.) with many (e.g., 1 million) single-nucleotide polymorphisms (SNPs) is perhaps the largest current wave in human genetic research. For investigators to be part of this wave, they need to answer key questions to their satisfaction and that of grant reviewers. Such questions include:. How many subjects do I need to study? We have downloaded a number of rep...

5

GWA Test Driver - Acknowledgements

http://gwatestdriver.ssg.uab.edu/acknowledgements.jsp

The development of this software and web site was funded by a UAB Health Services Foundation General Endowment Fund grant, and in part by grant R01GM081488 from the National Institutes of Health. David B. Allison. Hemant K. Tiwari.

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GWA Test Driver - Overview

Genome-wide association studies in which the association of clinically relevant phenotypes (e.g., obesity, diabetes, lupus, pulmonary hypertension, etc.) with many (e.g., 1 million) single-nucleotide polymorphisms (SNPs) is perhaps the largest current wave in human genetic research. For investigators to be part of this wave, they need to answer key questions to their satisfaction and that of grant reviewers. Such questions include:. How many subjects do I need to study? We have downloaded a number of rep...

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