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HBA1 and α-thalassemia - Home

HBA1 and α-thalassemia

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HBA1 and α-thalassemia - Home | hannongen677s11.weebly.com Reviews
<META>
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HBA1 and&nbsp;&alpha;-thalassemia
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1 gene
2 motifs
3 homology
4 chemical genetics
5 microarray
6 protein
7 domains
8 homology and phylogeny
9 ontology
10 interactions
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gene,motifs,homology,chemical genetics,microarray,protein,domains,homology and phylogeny,ontology,interactions,literature,future directions,alpha; thalassemia,symptoms of,the gene,effects on hemoglobin,beta;,references,ncbi bookshelf,colleen hannon
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HBA1 and α-thalassemia - Home | hannongen677s11.weebly.com Reviews

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HBA1 and&nbsp;&alpha;-thalassemia

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1

Motifs - HBA1 and α-thalassemia

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HBA1 and α-thalassemia. RNAi and Model Organisms. This page was produced as an assignment for Genetics 677. An undergraduate course at UW-Madison. These DNA motifs were generated by MEME. Using another site, Motif. I was able to find 7 DNA motifs: an EGF1-like domain. An integrins beta chain cysteine-rich domain. A C-terminal cystine kno. T, an anaphylatoxin domain. 2Fe-2S ferredoxins, iron-sulfur binding region. And a mammalian defensins motif. Http:/ meme.sdsc.edu/meme4 6 0/intro.html. A generalized pr...

2

Domains - HBA1 and α-thalassemia

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HBA1 and α-thalassemia. RNAi and Model Organisms. This page was produced as an assignment for Genetics 677. An undergraduate course at UW-Madison. The HBA1 protein contains a globin. From Pfam, showing four globin domains. After entering the protein sequence into SMART. I received the result: "No domains, repeats, motifs or features could be predicted with confidence." [2]. The most globins present in one species are seen in. PNAS 1998; 95: 5. 857-5864. ( PubMed. Phylogenomic profile of globins. Vinograd...

3

Interactions - HBA1 and α-thalassemia

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HBA1 and α-thalassemia. RNAi and Model Organisms. This page was produced as an assignment for Genetics 677. An undergraduate course at UW-Madison. Interactions of HBA1 with other proteins. This interaction network was generated by String. Interactions are shown with HBB, which encodes the. Beta;-chain of hemoglobin. Additionally, an interaction is shown with HBE1, which is an epsilon(ε)-globin. Two. Chains form a heterotetramer with two α-globin chains to produce an embryonic form of hemoglobin [1].

4

Microarray - HBA1 and α-thalassemia

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HBA1 and α-thalassemia. RNAi and Model Organisms. This page was produced as an assignment for Genetics 677. An undergraduate course at UW-Madison. Using NCBI's Gene Expression Omnibus (GEO). Database [1], I searched for microarray data on HBA1. There was very little information on HBA1. But there some expression data for HBA2. Was available. None of the data sets were from work on α-thalassemia, but rather the expression of HBA2. Though limited microarray data relating to. Alpha;-thalassemia was available.

5

Chemical Genetics - HBA1 and α-thalassemia

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HBA1 and α-thalassemia. RNAi and Model Organisms. This page was produced as an assignment for Genetics 677. An undergraduate course at UW-Madison. Lenalidomide. Structure from PubChem. Chemical genetics refers to the use of small molecules to alter protein function or gene expression. Using the NCBI database PubChem. I searched for chemicals that have an effect on HBA1. Though no results were found for HBA1,. One small molecule was shown to have an effect on HBA2. National Center for Biotechnology Inform...

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HBA1 and α-thalassemia - Home

HBA1 and α-thalassemia. RNAi and Model Organisms. This page was produced as an assignment for Genetics 677. An undergraduate course at UW-Madison. Alpha;-thalassemia usually become apparent in infancy or early childhood. Many patients are relatively unaffected by the disease and may not require treatment [2], but some patients who experience more severe effects of the disease may require frequent blood transfusions [3]. Cluster of α-globin genes on chromosome 16. α1 = HBA1. [2]. Globin chains. [2]. When ...

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