HART-LAB.ORG

HartLab

Hart Lab at MD Anderson. Finding new therapeutic targets. The ability to do saturating knockout screens on cancer cell lines is transforming cancer genetics. With pooled library CRISPR-Cas9 screens, we are now able to comprehensively define which genes are essential for cellular proliferation across all backgrounds ( "core fitness genes". And differentiate them from those genes required only in the presence of a particular oncogenic driver or genetic background ( "context fitness genes".

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HartLab | hart-lab.org Reviews

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Hart Lab at MD Anderson. Finding new therapeutic targets. The ability to do saturating knockout screens on cancer cell lines is transforming cancer genetics. With pooled library CRISPR-Cas9 screens, we are now able to comprehensively define which genes are essential for cellular proliferation across all backgrounds ( core fitness genes. And differentiate them from those genes required only in the presence of a particular oncogenic driver or genetic background ( context fitness genes.

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2 downloads

3 publications

4 data and downloads

5 positions

6 useful links

7 tko website

8 bagel at sourceforge

9 coupons

10 reviews

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HartLab | hart-lab.org Reviews

https://hart-lab.org

Hart Lab at MD Anderson. Finding new therapeutic targets. The ability to do saturating knockout screens on cancer cell lines is transforming cancer genetics. With pooled library CRISPR-Cas9 screens, we are now able to comprehensively define which genes are essential for cellular proliferation across all backgrounds ( "core fitness genes". And differentiate them from those genes required only in the presence of a particular oncogenic driver or genetic background ( "context fitness genes".

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hart-lab.org

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HartLab

http://www.hart-lab.org/downloads.html

Hart Lab at MD Anderson. You can visit the TKO. Website for all publicly available CRISPR screen data to date. You can visit the BAGEL page at Sourceforge. Looking for something specific? Email info at hart-lab dot org.

2

HartLab

http://www.hart-lab.org/publications.html

Hart Lab at MD Anderson. High-resolution CRISPR screens reveal fitness genes and genotype-specific cancer liabilities. Chandrashekhar M, Aregger M, Steinhart Z, Brown KR, MacLeod G, Mis M, Zimmermann M, Fradet-Turcotte A, Sun S, Mero P, Dirks P, Sidhu S, Roth P, Rissland OS, Durocher D, Angers S, Moffat J. Cell 2015. doi: 10.1016/j.cell.2015.11.015 [ Cell. Charles Boone and Brenda J. Andrews Science 2015. Nov 27;6264(350):1028. Science. Older publications will be posted soon.

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HartLab

http://www.hart-lab.org/positions.html

Hart Lab at MD Anderson. What do we do? Do you want to join the leading edge in cancer functional genomics? YES, WE'RE HIRING. We have immediate openings. At the postdoctoral, research associate (non-PhD), or research scientist (PhD) level. Current projects include:. Working with experimental researchers to improve and validate CRISPR guide library design;. MD Anderson provides a generous pay scale for computational postdocs ($65k! And Houston is an amazingly diverse city with a relatively low cost of li...

4

HartLab

http://www.hart-lab.org/index.html

Hart Lab at MD Anderson. Finding new therapeutic targets. The ability to do saturating knockout screens on cancer cell lines is transforming cancer genetics. With pooled library CRISPR-Cas9 screens, we are now able to comprehensively define which genes are essential for cellular proliferation across all backgrounds ( "core fitness genes". And differentiate them from those genes required only in the presence of a particular oncogenic driver or genetic background ( "context fitness genes".

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HartLab

Hart Lab at MD Anderson. Finding new therapeutic targets. The ability to do saturating knockout screens on cancer cell lines is transforming cancer genetics. With pooled library CRISPR-Cas9 screens, we are now able to comprehensively define which genes are essential for cellular proliferation across all backgrounds ( "core fitness genes". And differentiate them from those genes required only in the presence of a particular oncogenic driver or genetic background ( "context fitness genes".

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