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Histone deacetylase (HDAC) Inhibitors DatabaseInformation about molecules or drugs that block HDACs
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Information about molecules or drugs that block HDACs
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Vladimir K. Maslenko
Vladimir K. Maslenko
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Vladimir K. Maslenko
Vladimir K. Maslenko
127 Lenina●●●●●●●●●●office 215
Ob●●sk , Kaluga region, 249030
RU
View this contact
Vladimir K. Maslenko
Vladimir K. Maslenko
127 Lenina●●●●●●●●●●office 215
Ob●●sk , Kaluga region, 249030
RU
View this contact
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Histone deacetylase (HDAC) Inhibitors Database | hdacis.com Reviews
https://hdacis.com
Information about molecules or drugs that block HDACs
hdacis.com
LBH-589, LBN-589, LBH589, Panobinostat, NVP-LBH589 - HDAC Inhibitor
http://www.hdacis.com/panobinostat.html
LBH-589 is a hydroxamic acid based HDACi with a structure similar to vorinostat. It is in phase I clinical trials for cutaneous T-cell lymphoma as an oral agent. It has a longer half-life than vorinostat. LBH-589; LBN-589; LBH589; Panobinostat, NVP-LBH589. 1) Qun Zhou, Peter Atadja, Nancy E. Davidson. Histone Deacetylase Inhibitor LBH589 Reactivates Silenced Estrogen Receptor Alpha (ER) Gene Expression without Loss of DNA Hypermethylation. Cancer Biology and Therapy 6:1, 64-69, January 2007.
PCI-24781, CRA-024781 - HDAC Inhibitor
http://www.hdacis.com/CRA-024781.html
PCI-24781 (formerly CRA-024781) is a broad spectrum phenyl hydroxamic acid-based, orally bioavailable compound currently in phase I clinical trials for the treatment of neoplastic diseases. The compound is a specific inhibitor of multiple HDAC isoforms that potently inhibits tumor growth in vivo. CRA-02478; CRA024781; CRA-024781. 2) Adimoolam et al. HDAC inhibitor PCI-24781 decreases RAD51 expression and inhibits homologous recombination. PNAS December 4, 2007 vol. 104 no. 49 19482-19487.
CBHA, m-Carboxycinnamic acid bis-Hydroxamide - HDAC Inhibitor
http://www.hdacis.com/CBHA.html
CBHA is a member of a recently synthesized family of hybrid polar compounds that have been shown to be inhibitors of HDAC and potent inducers of transformed cell growth arrest and terminal differentiation at micromolar (LD50 range, 1 4 μM) concentrations. M-Carboxycinnamic acid bis-Hydroxamide; M-carboxycinnamic acid bishydroxamide. This compound inhibits growth of human neuroblastoma xenografts in vivo alone and synergistically with retinoic acid. 2010-2015 www.hdacis.com Privacy Policy.
Valproic acid (VPA) - HDAC Inhibitor
http://www.hdacis.com/Valproic-Acid.html
Valproic acid (VPA) has been used in the treatment of epilepsy for almost 30 years. The compound has recently been shown to have activity as HDAC inhibitor. Very soluble in organic solvents. Dipropylacetic acid, VPA, myproic acid. 1) Kuendgen et al. The Histone Deacetylase (HDAC) Inhibitor Valproic Acid as Monotherapy or in Combination with All-Trans Retinoic Acid in Patients with Acute Myeloid Leukemia. Cancer Volume 106 Issue 1, Pages 1-235. 2010-2015 www.hdacis.com Privacy Policy.
Sodium Butyrate - HDAC Inhibitor
http://www.hdacis.com/Sodium-Butyrate.html
Sodium butyrate, a short-chain fatty acid, is the most common and physiologic member of HDAC inhibitors because it is formed in the colon by fermentation of dietary fibers. NaB, SB, NaBu, Butanoic acid sodium salt, Sodium propanecarboxylate. Sodium butyrate is able to induce cell cycle arrest, differentiation and apoptosis in various cancer cells. The compound in millimolar concentrations causes an accumulation of acetylated histone species in a variety of vertebrate cell lines.
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ChemKnol: Free Chemical Databases Info
http://www.chemknol.com/2012/01/chemical-databases.html
ChemKnol is a worldwide leading source for the latest Chemical News and Information, Knowledge, Searches, Blogs, Reviews, Articles, Videos and Resources related links on for the community of Chemical, Pharmaceutical, Biotech and Healthcare-related Professionals and Industry. ChemKnol provides a digital podium for communicating thought leadership and innovation within the Chemical Industry and Professionals. http:/ www.chemknol.com/. Free Chemical Databases Info. Http:/ www.ebi.ac.uk/chebi/. Are you looki...
Histone deacetylase inhibitors - ChemInfo – Chemistry Blog
http://www.allcheminfo.com/drug-discovery/histone-deacetylase-inhibitors.html
ChemInfo – Chemistry Blog. Discuss anything related to chemistry and chemical industry. August 14, 2010: 3:49 pm: admin. Histone deacetylase inhibitors (HDACis) are emerging as a new class of anticancer drugs and have been shown to alter gene transcription and exert antitumor effects such as growth arrest, differentiation, apoptosis, and inhibition of tumor angiogenesis. The interest in HDAC inhibitors. To treat the rare cancer cutaneous T-cell lymphoma (CTCL). SNDX-275, MS-27-275, MS-275); BML-210.
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The Bradley Research Group is one of the leading Combinatorial Chemistry and High-Throughput Chemical Biology groups in the UK. The Bradley group has worked in the micro-array area for some four years and has led to the development of a generic HT screening method for the determination of the substrate specificity of proteases, kinases and phosphatases etc. Provides an overview of peptides. And a glossary as well as information about peptide bonds and synthesis. Extrasynthese and small companies. PubChem...
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Histone deacetylase (HDAC) Inhibitors Database
Histone deacetylases (HDACs) are a class of enzymes found in bacteria, fungi, plants and animals that remove the acetyl group from the ε- amino. Groups of lysine residues located in the NH2 terminal tails of core histones. There are 18 known human histone deacetylases, grouped into four classes based on the structure of their accessory domains. The interest in HDAC inhibitors began almost 30 years ago during some studies designed to understand why dimethyl sulfoxide (DMSO) caused terminal differentiation...
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