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HegeLab.org

Aacute;LLÁSHIRDETÉSEK: in silico. We are an experimental and computation group studying ATP Binding Cassette (ABC) proteins. The altered function or expression of these proteins lead to various diseases, such as pseudoxanthoma elasticum, cystic fibrosis, diabetes mellitus type II, adrenoleukodystrophy, etc. We aim to understand the molecular level processes resulting in ABC associated disorders and design strategies to overcome the effect of the altered functional state of ABC proteins.

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Tamas Hegedus

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Bud●●●est , HU, 1111

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he●●●●●@biomembrane.hu

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Biohegedus.org

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Bud●●●est , HU, 1111

HU

36.2●●●●3411
he●●●●●@biomembrane.hu

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Biohegedus.org

Tamas Hegedus

Bertal●●●●●●s u 16

Bud●●●est , HU, 1111

HU

36.2●●●●3411
he●●●●●@biomembrane.hu

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Aacute;LLÁSHIRDETÉSEK: in silico. We are an experimental and computation group studying ATP Binding Cassette (ABC) proteins. The altered function or expression of these proteins lead to various diseases, such as pseudoxanthoma elasticum, cystic fibrosis, diabetes mellitus type II, adrenoleukodystrophy, etc. We aim to understand the molecular level processes resulting in ABC associated disorders and design strategies to overcome the effect of the altered functional state of ABC proteins.
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HegeLab.org | hegelab.org Reviews

https://hegelab.org

Aacute;LLÁSHIRDETÉSEK: in silico. We are an experimental and computation group studying ATP Binding Cassette (ABC) proteins. The altered function or expression of these proteins lead to various diseases, such as pseudoxanthoma elasticum, cystic fibrosis, diabetes mellitus type II, adrenoleukodystrophy, etc. We aim to understand the molecular level processes resulting in ABC associated disorders and design strategies to overcome the effect of the altered functional state of ABC proteins.

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cello.hegelab.org cello.hegelab.org

Apache2 Debian Default Page: It works

Apache2 Debian Default Page. This is the default welcome page used to test the correct operation of the Apache2 server after installation on Debian systems. If you can read this page, it means that the Apache HTTP server installed at this site is working properly. You should replace this file. Before continuing to operate your HTTP server. Refer to this for the full documentation. Documentation for the web server itself can be found by accessing the manual. Package was installed on this server. Is always...

abcmutations.hegelab.org abcmutations.hegelab.org

ABCMdb

ABCMdb: The mutation browser. The ABC mutations database contains mentions of ABC protein mutations extracted from the literature using the MutMiner. Automated data mining method. Pipeline was designed to recognize any mention of amino acid substitution occuring in text, including natural and experimental mutations found in genotypic or protein. Mutations were extracted from the full-text version of PubMed papers resulting from keyword searches for various ABC proteins. The overall accuracy of the. The w...

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HegeLab.org

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Our team is part of the. Molecular Biophysics Research Group of the Hungarian Academy of Sciences. Head: Miklós Kellermayer. Head: Balázs Sarkadi. We have also launched systems biology studies to understand how the chemodefense/chemoimmune system, which includes multi-drug ABC transporters, metabolic enzymes, and nuclear recpetors, protect cells from xenobiotics. Please see more details in the Research. Tamás, Áron, Kristóf, Zita, Dani, Attila, Hédi, Hajni, Gábor.

3

HegeLab.org

http://www.hegelab.org/members.html

PI, Senior Research Fellow. Tóth, Ágota. Student, Péter Pázmány Catholic University. Visiting scholar from Babes-Bolyai University, Kolozsvár, Romania. Borsodi, Dávid (2010-2011). Student, Budapest University of Technology and Economics, His thesis (English). Gyimesi, Gergely (2009-2012). PhD student; Research Fellow; Postdoc at University of Bern, Switzerland. Sarankó, Hajnalka (2010-2014). Tóth, Attila (2012-2015). Erdei, Áron (2012-2015). Student, Péter Pázmány Catholic University.

4

HegeLab.org

http://www.hegelab.org/databases.html

Software, Databases and Services. MutMiner mutation extraction pipeline. ABCMdb: ABC protein mutations database. PyWHAM: Weighted Histogram Analysis Method calculations in Python.

5

HegeLab.org

http://www.hegelab.org/publications.html

Click here for ALL publications. Veit, G., Avramescu, R.G., Perdomo, D., Phuan, P.W., Bagdany, M., Apaja, pm, Borot, F., Szöllősi, D.,. Wu, YS., Finkbeiner, W.E., Hegedus, T.,. Verkman, A.S., Lukacs, G.L., Some gating potentiators, including VX-770, diminish ΔF508-CFTR functional expression. Sci Transl Med. 2014 Jul 23;6(246):246 PubMed: 25101887. Horváth, T., Han, KH, Dokholyan, N.V., Tompa, P., Kalmár, L., Hegedűs, T. 2014 (accepted for publication). Telbisz, Á., Özvegy-Laczka, C., Erdős, G. Gáspár, M&...

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ABCMdb

http://abcmutations.hegelab.org/about

ABC (ATP-Binding Cassette) transporters. With altered function are responsible for numerous human diseases. To overcome the pathological phenomena and plan strategies to modulate their function, the mechanism of the action of ABC transporters is studied extensively. The major way to learn about the mechanism of ABC transporters is designing and studying mutant constructs. Selecting the position and amino acid for mutagenetic experiments. 1 Mutations are identified automatically and stored in the database.

abcmutations.hegelab.org abcmutations.hegelab.org

ABCMdb

http://abcmutations.hegelab.org/usage

Leaving comments and annotations. The ABCMdb web interface. Has been designed to be self-explanatory and easily explorable. Most colored texts are clickable. And point to a page with detailed information on the highlighted term. To browse the mutations of a specific protein, start from the Browse. Menu, expand the protein family of interest with the " show. Button, and click on any of the " list mutations. Links This will take you to the protein details. View, where clicking on the " details. Link next t...

abcmutations.hegelab.org abcmutations.hegelab.org

ABCMdb

http://abcmutations.hegelab.org/browse

List of mined mutations; map mm:. Map mm to a strcuture/alignment; m in coding regions:. List of mutations from ClinVar and LSDBs; TF binding sites:. List of well defined transcription factor binding sites. M in coding regions]. M in non-coding regions]. M in coding regions]. M in non-coding regions]. M in coding regions]. M in non-coding regions]. M in non-coding regions]. M in coding regions]. M in coding regions]. M in coding regions]. M in coding regions]. M in coding regions]. M in coding regions].

abcmutations.hegelab.org abcmutations.hegelab.org

ABCMdb

http://abcmutations.hegelab.org/statistics

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Aacute;LLÁSHIRDETÉSEK: in silico. We are an experimental and computation group studying ATP Binding Cassette (ABC) proteins. The altered function or expression of these proteins lead to various diseases, such as pseudoxanthoma elasticum, cystic fibrosis, diabetes mellitus type II, adrenoleukodystrophy, etc. We aim to understand the molecular level processes resulting in ABC associated disorders and design strategies to overcome the effect of the altered functional state of ABC proteins.

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