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The Huguenard Lab

Studies of Thalamocortical Synchrony and Epilepsy. John R. Huguenard, Ph.D. We are interested in the neuronal mechanisms that underlie synchronous oscillatory activity in the thalamus, cortex and the massively interconnected thalamocortical system. Such oscillations are related to cognitive processes, normal sleep activities and certain forms of epilepsy. Our approach is an analysis of the discrete components that make up thalamic and cortical circuits, and reconstitution of components into both in vitro.

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The Huguenard Lab | hlab.stanford.edu Reviews

<META> DESCRIPTION

Studies of Thalamocortical Synchrony and Epilepsy. John R. Huguenard, Ph.D. We are interested in the neuronal mechanisms that underlie synchronous oscillatory activity in the thalamus, cortex and the massively interconnected thalamocortical system. Such oscillations are related to cognitive processes, normal sleep activities and certain forms of epilepsy. Our approach is an analysis of the discrete components that make up thalamic and cortical circuits, and reconstitution of components into both in vitro.

<META> KEYWORDS

1 thalamus

2 synchrony

3 neural networks

4 GABA

5 GAT

6 LTS

7 Cav3.1

8 benzodiazepine

9 endocannabinoid

10 swd

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the huguenard lab,in brain slices,awards and news,people,publications,misc lab photos,some completed projects,metatape analysis program,epilepsy training program,lab meeting,links,visitor number,comments or questions,johnhuguenard@stanford edu

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The Huguenard Lab | hlab.stanford.edu Reviews

https://hlab.stanford.edu

Studies of Thalamocortical Synchrony and Epilepsy. John R. Huguenard, Ph.D. We are interested in the neuronal mechanisms that underlie synchronous oscillatory activity in the thalamus, cortex and the massively interconnected thalamocortical system. Such oscillations are related to cognitive processes, normal sleep activities and certain forms of epilepsy. Our approach is an analysis of the discrete components that make up thalamic and cortical circuits, and reconstitution of components into both in vitro.

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denizens of the huguenard lab

http://hlab.stanford.edu/photos/labphotos

Denizens of the huguenard lab. New evidence suggests that endozpines, the brain's naturally occurring benzodiazepines, are at the heart of a built-in anti-seizure system. The goals of my project are to uncover the mechanisms that underlie production and release of endozepines and to determine whether controlling endozepine release can stop seizure activity. I consider karaoke a competitive sport. I have quick, cat-like reflexes. Meow! I am interested in the role of Shank3 in regulating the dynamic assemb...

2

Huguenard Lab Publications

http://hlab.stanford.edu/pubs.php

Bartolome J, Huguenard J. Slotkin TA (1980) Role of ornithine decarboxylase in cardiac growth and hypertrophy. Science. Wilson WA (1985) Suppression of repetitive firing of neurons by diphenylbarbituric acid. J Pharmacol Exp Ther. Zbicz KL, Lewis DV, Evans GJ, Wilson WA (1985) The ionic mechanism of the slow outward current in Aplysia neurons. J Neurophysiol. Lewis DV, Huguenard JR. Shen JM, Huguenard JR. Coulter DA, Huguenard JR. Coulter DA, Huguenard JR. Prince DA (1989) Characterization of ethosuximid...

3

Metatape analysis program

http://hlab.stanford.edu/meta.php

This program is a MS-DOS program to display and perform some rudimentary analyses of Axon Instruments pClamp(TM) data files, especially Clampex ( now with preliminary support for version 6 and 7-9! And Axotape files. I think its a nice quick way to review experimental data. It is fast and simple, and will generate output that you can import into drawing programs such as CorelDraw or Adobe Illustrator. NEW, On-line Documentation for METATAPE.

4

links

http://hlab.stanford.edu/links.php

Research Laboratories of Interest. Epilepsy Postdoctoral Training Program. Stanford Neuroscience PhD Program. Stanford Neuroscience Seminar Series. Electrophysiology of the Neuron.

5

Stanford University Epilepsy Training Program

http://hlab.stanford.edu/etg.php

Involved Departments and Faculty. Postdoctoral trainees: Qualifications, criteria. The institutional postdoctoral training program in neuroscience and epilepsy allows faculty in the Departments of Biological Sciences, Molecular and Cellular Physiology, Comparative Medicine, Neurology and Neurological Sciences, Neurobiology, and Psychiatry at. Animal models of epileptogenesis; anatomic techniques for intracellular labeling, immunocytochemistry and in situ. Liqun Luo, Ph.D. Biological Sciences. Robert Sapo...

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The Huguenard Lab

Studies of Thalamocortical Synchrony and Epilepsy. John R. Huguenard, Ph.D. We are interested in the neuronal mechanisms that underlie synchronous oscillatory activity in the thalamus, cortex and the massively interconnected thalamocortical system. Such oscillations are related to cognitive processes, normal sleep activities and certain forms of epilepsy. Our approach is an analysis of the discrete components that make up thalamic and cortical circuits, and reconstitution of components into both in vitro.

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