HOCHSCHILDLAB.MED.HARVARD.EDU

The Hochschild Lab

Transcription by the multi-subunit RNA polymerases is a complex process consisting of multiple steps at which regulation can occur. To understand the relevant molecular interactions and regulatory mechanisms, we are taking advantage of the relative simplicity of the prokaryotic transcription machinery and the power of bacterial genetics. The RNA polymerase (RNAP) core enzyme is evolutionarily conserved from bacteria to man, as has been strikingly confirmed by recent crystallographic studies. Accordingly, in

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The Hochschild Lab | hochschildlab.med.harvard.edu Reviews

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Transcription by the multi-subunit RNA polymerases is a complex process consisting of multiple steps at which regulation can occur. To understand the relevant molecular interactions and regulatory mechanisms, we are taking advantage of the relative simplicity of the prokaryotic transcription machinery and the power of bacterial genetics. The RNA polymerase (RNAP) core enzyme is evolutionarily conserved from bacteria to man, as has been strikingly confirmed by recent crystallographic studies. Accordingly, in

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1 multi-subunit RNA

2 polymerases

3 prokaryotic

4 bacteria

5 Harvard University

6 Research

7 Microbiology

8 Harvard Medical School

9 Harvard

10 HMS

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The Hochschild Lab | hochschildlab.med.harvard.edu Reviews

https://hochschildlab.med.harvard.edu

Transcription by the multi-subunit RNA polymerases is a complex process consisting of multiple steps at which regulation can occur. To understand the relevant molecular interactions and regulatory mechanisms, we are taking advantage of the relative simplicity of the prokaryotic transcription machinery and the power of bacterial genetics. The RNA polymerase (RNAP) core enzyme is evolutionarily conserved from bacteria to man, as has been strikingly confirmed by recent crystallographic studies. Accordingly, in

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hochschildlab.med.harvard.edu

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The Hochschild Lab

http://hochschildlab.med.harvard.edu/labmembers.html

Left to right - Sean Garrity, Padraig Deighan, Ann Hochschild, Andy Yuan,. Mrin Tavag, Chris Wells, Cristina Montero-Diez, Viknesh Sivanathan. Graduate Student - cmontero@fas.harvard.edu. Postdoctoral Fellow - padraig deighan@hms.harvard.edu. Graduate Student - sean garrity@student.hms.harvard.edu. Entela Nako (not shown). Graduate Student - enako@fas.harvard.edu. Postdoctoral Fellow - viknesh sivanathan@hms.harvard.edu. Research Assistant - mrinalini tavag@hms.harvard.edu.

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The Hochschild Lab

http://hochschildlab.med.harvard.edu/collaborations.html

Seth Darst - Rockefeller University. Ian Dodd and Barry Egan - University of Adelaide. Richard Ebright - Rutgers University. Debbie Hinton - NIH. Mitch Lewis - U Penn School of Medicine. Jeff Roberts - Cornell University. Konstantin Severinov - Rutgers University. Rao X, Deighan P, Hua Z, Hu X, Wang J, Luo M, Wang J, Liang Y, Zhong G, Hochschild A, Shen L. A regulator from Chlamydia trachomatis. Nickels BE, Roberts CW, Roberts JW, and Hochschild A. RNA-mediated destabilization of the σ. And the ß-flap of.

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The Hochschild Lab

http://hochschildlab.med.harvard.edu/publications.html

Recent Publications - Since 2002:. Rao X, Deighan P, Hua Z, Hu X, Wang J, Luo M, Wang J, Liang Y, Zhong G, Hochschild A, Shen L. A regulator from Chlamydia trachomatis. Modulates the activity of RNA polymerase through direct interaction with the β subunit and the primary σ subunit. Genes Dev. 2009, in press. Yuan AH, Nickels BE, Hochschild A. The bacteriophage T4 AsiA protein contacts the β-flap domain of RNA polymerase. Proc Natl Acad Sci U S A. 2009; 106(16):6597-602. Leibman M and Hochschild A. A ...

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The Hochschild Lab

http://hochschildlab.med.harvard.edu/index.html

Ann Hochschild - Department of Microbiology and Immunobiology. Harvard Medical School - 200 Longwood Avenue - Boston, MA 02115. Email: ahochschild@hms.harvard.edu.

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Ann Hochschild - Department of Microbiology and Immunobiology. Harvard Medical School - 200 Longwood Avenue - Boston, MA 02115. Email: ahochschild@hms.harvard.edu.

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