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Holt Lab | microbial genomics

Welcome to the website of Kat Holt and her microbial genomics lab, based at Melbourne University. To see what we get up to in the lab, check out the blog posts on recent papers. Lab members are listed here. Kat is currently a NHMRC Career Development Fellow and a Senior Research Fellow at the University Of Melbourne. She has a double degree…

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Holt Lab | microbial genomics | holtlab.net Reviews
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Welcome to the website of Kat Holt and her microbial genomics lab, based at Melbourne University. To see what we get up to in the lab, check out the blog posts on recent papers. Lab members are listed here. Kat is currently a NHMRC Career Development Fellow and a Senior Research Fellow at the University Of Melbourne. She has a double degree…
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Holt Lab | microbial genomics | holtlab.net Reviews

https://holtlab.net

Welcome to the website of Kat Holt and her microbial genomics lab, based at Melbourne University. To see what we get up to in the lab, check out the blog posts on recent papers. Lab members are listed here. Kat is currently a NHMRC Career Development Fellow and a Senior Research Fellow at the University Of Melbourne. She has a double degree…

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holtlab.net holtlab.net
1

assembly | Holt Lab

http://holtlab.net/tag/assembly

Bandage – View and navigate assembly graphs. New from Ryan Wick, a wonderful MSc (Bioinformatics) student in the lab:. Http:/ rrwick.github.io/Bandage/. Assembly graphs contain assembled contigs (nodes) but also the connections between those contigs (edges), which are not easily accessible to users. Bandage is a program for visualising assembly graphs using graph layout algorithms. By displaying connections between contigs, Bandage opens up new possibilities for analysing. February 25, 2015.

2

pangenome | Holt Lab

http://holtlab.net/tag/pangenome

Population genomics of Klebsiella. Well, after almost 6 years, our. Genomics paper is finally out! It’s a beast of a thing and there are still a million and one questions to address just from this one data set. For those interested in looking at the data for themselves, the raw reads are available under accession ERP000165. The assemblies are in Sylvain Brisse’s. At the Pasteur Institute, and the tree metadata are available for your interactive viewing pleasure in MicroReact. Whole genome diversity in.

3

antibiotic resistance | Holt Lab

http://holtlab.net/tag/antibiotic-resistance

Tracking down insertion sequences causing polymixin resistance in Acinetobacter baumannii. The first plasmid-borne colistin resistance gene was reported late last year. This was big news, but the vast majority of clinically relevant resistance to colistin and related polymixin drugs, which arises frequently in human patients being treated with these drugs, is due to. Mutations in chromosomal genes. This has been studied quite a lot recently in. Activity via point mutations or inactivating the regulator.

4

brig | Holt Lab

http://holtlab.net/tag/brig

Tools for bacterial comparative genomics. Yesterday I spoke at a workshop for JAMS TOAST (Sydney’s Joint Academic Microbiology Seminars – bioinformatics workshop)… I was asked to cover tools for comparative genomics, so I put together a list of the tried and tested programs that I find most useful for this kind of analysis. So here is the list. First, a few caveats…. These tools are useful for small-ish scale genomic comparisons, in the order of 2-20 genomes. De Bruijn graph assembly, incorporating multi...

5

papers | Holt Lab

http://holtlab.net/tag/papers

Global genomic framework for typhoid. It’s been over a year since we published the first global whole-genome snapshot of nearly 2000 genomes of the typhoid bacterium,. That paper focused on the emergence and global dissemination of what we’ve been calling for years the “H58” clone. See this blog post. And the emergence of fluoroquinolone resistant H58 sublineage in India and Nepal. Nature Communications: “. An extended genotyping framework for Salmonella enterica serovar Typhi, the cause of human typhoid.

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Holt Lab | microbial genomics

Welcome to the website of Kat Holt and her microbial genomics lab, based at Melbourne University. To see what we get up to in the lab, check out the blog posts on recent papers. Lab members are listed here. Kat is currently a NHMRC Career Development Fellow and a Senior Research Fellow at the University Of Melbourne. And Kat has recently been awarded a L’Oréal For Women In Science Australia and NZ Fellowship. 2013), the NHMRC Research Excellence Award for the Top-Ranked Career Development Fellow. We are ...

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