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hsp90.ca

Figures - HSP90 | HSP90

http://hsp90.ca/figures

Mechanisms & Interactions. Structure of the tetragonal form of the N-terminal domain of Hsp90 from yeast ( PDB ID: 1ah6. Figure 1. Structure of the tetragonal form of the N-terminal domain of Hsp90 from yeast ( PDB ID: 1ah6. Structure of full-length yeast Hsp90. Figure 2. Structure of full-length yeast Hsp90. Crystal structure of dimeric full-length yeast Hsp90 in complex with an ATP analogue and the co-chaperone p23/Sba-1 ( PDB ID: 2CG9. Structures of the full-length Hsp90 dimer. The N-terminal nucleoti...

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HSP90 Isoforms | HSP90

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Mechanisms & Interactions. IHC staining of inflammatory cells in mouse colon tissue, using Anti-Hsp90 (clone: D7A). The HSP90 proteins are ubiquitous and highly conserved molecular chaperones present from bacteria to mammals. HSP90 proteins can be found in the cytosol, ER, chloroplasts, mitochondria, and the nucleus. Eubacteria express a single Hsp90 homolog, referred to as. High-temperature protein G) which is absent in Archaebacteria with the exception of. 1 (Hsp90AA1, HspC1) and the constitutive Hsp90.

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HSP90 Mechanisms & Interactions | HSP90

http://hsp90.ca/mechanisms-interactions

Mechanisms & Interactions. HSP90: Mechanisms and Interactions. IF detection of Hsp90 in cancerous human colon tissue, using Anti-Hsp90 (clone: H9010). A comprehensive list of Hsp90-interacting proteins can be found at the website of Didier Picard. According to their biological function, Hsp90 client proteins can be classified in several groups such as transcription factors, TPR-domain proteins, protein kinases, structural proteins, and others. The Cdc-37/Hsp90 complex can be formed in an open or closed c...

hsp90.ca

Tables - HSP90 | HSP90

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Mechanisms & Interactions. Table 1: Human and mouse orthologs of Hsp90α1 (HspC1). Chr 14:102,547,075-102,606,086. Chr 12: 110,691,036-110,696,395. Table 2: HSP90s of various pro- and eukaryotic organisms. Hsp90α1, Hsp90AA1, Hsp86, HspCA, Hsp89, Hsp90A, renal carcinoma antigen NY-REN-38. Hsp90α2, Hsp90AA2, Hsp90α-like 3, HspCA. Hsp90β, Hsp90AB1, Hsp84, HSP90B, HspCB. Endoplasmin, Grp94, Gp96, Tra-1, Hsp90B1. Trap-1, Hsp75, Hsp90L. Slo, sloth, akineto, heat shock protein 90-alpha 1. AtHsp90.2, Hsp81-2.

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HSP90 Structure | HSP90

http://hsp90.ca/structure

Mechanisms & Interactions. HSP90s are abundant and highly specialized molecular chaperones crucially involved in several signalling pathways. They primarily exist as homodimers whose activity is regulated by ATP. Dimerization is essential for the vital functions of HSP90s. Nevertheless, higher oligomeric states including hexamers have been reported. It has been shown previously that oligomerization is induced after heat shock and in the presence of non-ionic detergents. Click image for larger version).

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HSP90 Protein Type | HSP90

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Mechanisms & Interactions. Hsp90 (total) visualized on a human keratinocyte line HaCat, using Anti-Hsp90 (total) (clone: 4F3.E8). The HSP90 family represents a group of well-conserved proteins with an average molecular mass of 90 kDa. There are two major cytosolic Hsp90 isoforms, the inducible Hsp90. 1 (HspC1) and the constitutive Hsp90. HspC3), commonly termed Hsp90. The HSP90 family members are encoded by a multigene family encompassing six genes and 11 pseudogenes in humans. The most studied genes are.

hsp90.ca

Discovery of HSP90 | HSP90

http://hsp90.ca/history

Mechanisms & Interactions. IHC staining of inflammatory cells in mouse colon tissue, using Anti-Hsp90 alpha (clone: Hyb-K41009). Heat shock protein 90 (Hsp90) was originally described amongst a defined set of heat shock proteins (HSPs) that are rapidly induced in fungal, plant and animal cells in response to acute thermal up-regulation. This HSP induction is referred to as the heat shock response (HSR) that is ubiquitous across the bacterial, archaeal and eukaryotic kingdoms. 83 kDa heat shock protein 2.

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HSP90 Disease Relevance | HSP90

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Mechanisms & Interactions. IHC detection of Hsp90 in cancerous human colon tissue, using Anti-Hsp90 (clone: H9010). A growing wealth of evidence indicates the pivotal role of Hsp90 in tumourigenesis. Constitutively elevated levels of Hsp90 can be found in a broad spectrum of cancers suggesting a central role in survival and growth of malignant cells. 1 to the heterodimeric cell surface receptor Her-2/Her-3 thereby inducing HSF-1 stabilization which consequently enhanced cell survival and transformation.

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HSP90 Molecular Weight | HSP90

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Mechanisms & Interactions. IHC staining of inflammatory cells and epithelia mucosa in mouse colon tissues, using Anti-Hsp90 (clone: AC-16). The HSP90 family represents a group of well-conserved proteins with an average molecular mass of 90 kDa. There are two major cytosolic Hsp90 isoforms, the inducible Hsp90. 1 (HspC1) and the constitutive Hsp90. HspC3), commonly termed Hsp90. The HSP90 family members are encoded by a multigene family encompassing six genes and 11 pseudogenes in humans.

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References - HSP90 | HSP90

http://hsp90.ca/references

Mechanisms & Interactions. 1 Csermely,P., Schnaider,T., Soti,C., Prohaszka,Z., and Nardai,G. The 90-kDa molecular chaperone family: structure, function, and clinical applications. A comprehensive review. Pharmacol. Ther. 79, 129-168 (1998). [PubMed]. 2 Felts,S.J. et al. The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties. J. Biol. Chem. 275, 3305-3312 (2000). [PubMed]. Novartis. Found. Symp. 291, 86-95 (2008). [PubMed]. 10 Lindquist,S. Regulation of protein ...