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oncologyblogger.com

“Ploidy Conveyer” reverse aging on hepatocytes - Drug Discovery Blog

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Hi You have not added the sites yet, go to plugin's option page to add your sites. Stem Cell Biology Blog. Ploidy Conveyer reverse aging on hepatocytes. Richard P. Schultz /. PRB pathways. Induction of multiple rounds continuous cell division is hard to apply in any animal model. Taking advantage of serial hepatocyte transplantation assays in the fumarylacetoacetate hydrolase deficient (Fah. Laquo; Xultophy , a novel anti-diabetes, anti-adiposis drug from Novo Nordisk. Leave a comment Cancel reply. Profi...

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Small molecular probe and drug discovery

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Hi You have not added the sites yet, go to plugin's option page to add your sites. Stem Cell Biology Blog. Small molecular probe and drug discovery. Richard P. Schultz /. Small molecule chemical probes play increasingly important roles in proteomics especially in the study of functional proteomics. The use of small molecule labeled probe has made lots of disease related targets come under observation. It is a powerful tool in drug discovery and development. Laquo; Drug development process. Stem Cell Biol...

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Xultophy®, a novel anti-diabetes, anti-adiposis drug from Novo Nordisk - Drug Discovery Blog

http://oncologyblogger.com/xultophy-novel-anti-diabetes-anti-adiposis-drug-novo-nordisk

Hi You have not added the sites yet, go to plugin's option page to add your sites. Stem Cell Biology Blog. Xultophy , a novel anti-diabetes, anti-adiposis drug from Novo Nordisk. Richard P. Schultz /. Xultophy really represents a new paradigm with the potential to transform how type 2 diabetes is treated. Once-daily injection obviously provides convenience and reduces suffering for type 2 diabetes patients. Meanwhile, the action on weight control of Xultophy will improve glucose tolerance in insu...Profi...

oncologyblogger.com

Drug Discovery Blog - Page 2 of 11 - high-throughput screening, high-content screening, lead-optimization, and new technologies in drug discovery

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Hi You have not added the sites yet, go to plugin's option page to add your sites. Stem Cell Biology Blog. Watch depressive tendencies in patients with Parkinson’s disease. Richard P. Schultz /. Not long ago, a famous comedian Robin Williams is suspected to suicide due to the depression, this event pushed depression again to the front of the public. PNAS: Dual roles of aspirin. Richard P. Schultz /. The corresponding author of this article, Edward A. Dennis, said that aspirin could increase the accum...

stemcellgeek.com

Stem Cell Biology Blog - Page 2 of 2 - including ESCs&iPSCs, adult stem cell, pluripotency, reprogramming, differentiation, transdifferentiation, stem cell niches, regenerative medicine, stem cell research ethical issues

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Stem Cell Biology Blog. Chemistry and Drug Data. March 20, 2014. March 20, 2014. At the Institute of Bioengineering Ecole Polytechnique Fédérale de Lausanne in Lausanne Switzerland discovered that one protein, namely placenta growth factor-2, has the C terminal that makes the protein powerfully bind to the extracellular matrix. The investigators discovered that if a domain (PlGF-2. March 20, 2014. Stem Cell Biology Blog. March 20, 2014. Laquo; Previous Page. Chemistry and Drug Data.

stemcellgeek.com

Transcription factor binding dynamics during human ES cell differentiation - Stem Cell Biology Blog

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Stem Cell Biology Blog. Chemistry and Drug Data. April 2, 2015. Transcription factor binding dynamics during human ES cell differentiation. April 2, 2015. Cell differentiation is a basic biology process. Epigenetic modifications, such as DNA methylation and posttranslational modifications of the various histone tails, are essential for normal development. Here, we analysis transcription factor binding dynamics during cell differentiation. To summary, our work shows transcription factor binding, downstrea...

stemcellgeek.com

iPS

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Stem Cell Biology Blog. Chemistry and Drug Data. April 3, 2014. April 3, 2014. Now our lab is inducing mouse iPS cells using chemical compounds according to the paper published in Science. We can observe a significant change in cell morphology and the cells formed clone-like tight clusters. Some pluripotent genes’ expression was up-regulated, but the key gene Oct4. Was not even for two months reprogramming! Is anyone else interested in the mouse iPS chemical reprogramming strategy? 1 P Hou et al.

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nuclear transfer

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Stem Cell Biology Blog. Chemistry and Drug Data. April 1, 2014. April 1, 2014. Somatic cell nuclear transfer is regarded as a form of cloning. Like Dolly sheep, this procedure involved transfer of the nucleus from a terminally differentiated cell into an enucleated oocyte. For mammalian cloning, especially for human, the quality of oocyte (unfertilized egg) is very important to the success ( 1. However, the technique is constrained by the limitations of oocyte availability. 1Y Yu et al. 2 A Riaz et al.

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Trans-differentiation

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Stem Cell Biology Blog. Chemistry and Drug Data. April 9, 2014. April 9, 2014. Now a Chinese group from Shanghai report that NPCs can be generated from mouse embryonic fibroblasts (MEFs) by a chemical cocktail, namely VCR (V, VPA, an inhibitor of HDACs. C, CHIR99021, an inhibitor of GSK-3 kinases. And R, Repsox, an inhibitor of TGF-β pathways. Transcription factor binding dynamics during human ES cell differentiation. Leave a comment Cancel reply. Your email address will not be published.