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HCP Information for Once-Daily IMBRUVICA® (ibrutinib) | HCP

Learn how IMBRUVICA® works & affects 3 key malignant B-cell processes to treat MCL, CLL & Waldenström's macroglobulinemia. See full prescribing and safety information.

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HCP Information for Once-Daily IMBRUVICA® (ibrutinib) | HCP | imbruvicahcp.com Reviews
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Learn how IMBRUVICA® works & affects 3 key malignant B-cell processes to treat MCL, CLL & Waldenström's macroglobulinemia. See full prescribing and safety information.
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1 important safety information
2 prescribing information
3 patient site
4 cancer type
5 efficacy
6 safety
7 dosing
8 support and resources
9 access to imbruvica
10 mycustomargument ; search
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HCP Information for Once-Daily IMBRUVICA® (ibrutinib) | HCP | imbruvicahcp.com Reviews

https://imbruvicahcp.com

Learn how IMBRUVICA® works & affects 3 key malignant B-cell processes to treat MCL, CLL & Waldenström's macroglobulinemia. See full prescribing and safety information.

INTERNAL PAGES

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1

CLL: Treatment-Related Lymphocytosis | IMBRUVICA® (ibrutinib) | HCP

https://www.imbruvicahcp.com/safety/cll/lymphocytosis-key-considerations

Register for More Information. Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma. Treatment-Related Lymphocytosis in CLL/SLL. Understanding IMBRUVICA (ibrutinib) treatment-related lymphocytosis. Lymphocytosis is an increase in the number of lymphocytes in the blood. Therapies that interfere with trafficking and adhesion of malignant lymphocytes by disrupting B-cell signaling can result in treatment-related lymphocytosis. Lymphocytosis resolves by a median of 14 weeks (range, 0.1 to 104 weeks).

2

Chronic Lymphocytic Leukemia (CLL) Treatment | IMBRUVICA® (ibrutinib) | HCP

https://www.imbruvicahcp.com/cll

Register for More Information. Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma. IMBRUVICA can be used as a single agent or in combination with BR to treat patients with CLL/SLL. IMBRUVICA (ibrutinib) is indicated for the treatment of patients with chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL). CLL/SLL WITH 17p DELETION. IMBRUVICA is indicated for the treatment of CLL/SLL patients with 17p deletion. IMBRUVICA (ibrutinib) Prescribing Information. Pharmacyclics LLC. 2016. Grade...

3

CLL Efficacy Data: Progression-free Survival (PFS) | IMBRUVICA® (ibrutinib) | HCP

https://www.imbruvicahcp.com/cll/efficacy-data/progression-free-survival

Register for More Information. Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma. Progression-Free Survival in CLL/SLL. Progression-free survival (PFS) in chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL). Del 17p (Single Agent). 2 primary endpoint: IMBRUVICA (ibrutinib) achieved an 84% reduction in risk of progression or death vs chlorambucil in frontline CLL/SLL in patients 65 years. Median follow-up was 18 months. N Engl J Med. Median follow-up was 9.4 months. IMBRUVICA is the ...

4

MCL Efficacy Data: Mechanism of Action | IMBRUVICA® (ibrutinib) | HCP

https://www.imbruvicahcp.com/mcl/mechanism-of-action

Register for More Information. A first in class, oral covalent BTK inhibitor. IMBRUVICA (ibrutinib) inhibits BTK to disrupt 3 key malignant B-cell processes*. IMBRUVICA (ibrutinib) inhibits BTK to disrupt 3 key malignant B-cell processes*. Inhibits proliferation and survival. Modulates chemotaxis and trafficking. 1,5,7,9,11-14. As demonstrated by in vitro and in vivo studies. Watch this video to see how IMBRUVICA works. Correlation to clinical effect has not been established. 2013;54(11):2385-2391. 3.

5

MCL Efficacy Data: Overall Response Rate | IMBRUVICA® (ibrutinib) | HCP

https://www.imbruvicahcp.com/mcl/efficacy-data/overall-response-rates

Register for More Information. Overall Response Rate for Previously Treated MCL. Response rates in previously treated mantle cell lymphoma (MCL). Primary endpoint: 65.8% of patients treated with IMBRUVICA (ibrutinib). Achieved a response in the phase 2 clinical trial. CR=complete response; PR=partial response; CI=confidence interval. 171% of patients had a complete response (CR). ORR was assessed according to the revised International Working Group for non-Hodgkin's lymphoma criteria. Grade 3 or higher b...

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Update Your Preferences | IMBRUVICA® (ibrutinib)

https://www.imbruvica.com/unsubscribe

Important Side Effect Information. From IMBRUVICA access and affordability to nurse call support—we're here to help. Important Side Effect Information. YOU&i™ Support Program. Important Side Effect Information. Please check one box*. I do not wish to receive e-mail or mail from the YOU&i Support Program at this time. I do not wish to receive calls from a YOU&i nurse at this time. You are now leaving www.IMBRUVICA.com. Are you a healthcare professional? IMPORTANT SIDE EFFECT INFORMATION. Have or had heart...

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Patient Resources & Information for IMBRUVICA® (ibrutinib)

https://www.imbruvica.com/isi

Important Side Effect Information. From IMBRUVICA access and affordability to nurse call support—we're here to help. Important Side Effect Information. YOU&i™ Support Program. Important Side Effect Information. No more than $10 per month*. Or call 1-877-877-3536, Monday-Friday, 8 AM. IMBRUVICA works differently than other treatments such as chemotherapy. IMBRUVICA is an oral therapy you take at home. You are now leaving www.IMBRUVICA.com. By clicking "OK" below you will be taken to a website that may con...

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What Is Waldenström’s Macroglobulinemia (WM) | IMBRUVICA® (ibrutinib)

https://www.imbruvica.com/wm

Important Side Effect Information. From IMBRUVICA access and affordability to nurse call support—we're here to help. Important Side Effect Information. YOU&i™ Support Program. Important Side Effect Information. IMBRUVICA (ibrutinib) is a once-daily, oral WM medication. With no chemotherapy required. Understanding Waldenström’s Macroglobulinemia (WM). Waldenström’s macroglobulinemia (WM) may seem overwhelming at first, but understanding it can help you feel more at ease. WM is a rare type of. In a clinica...

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What Is Mantle Cell Lymphoma | IMBRUVICA® (ibrutinib)

https://www.imbruvica.com/mcl

Important Side Effect Information. From IMBRUVICA access and affordability to nurse call support—we're here to help. Important Side Effect Information. YOU&i™ Support Program. Important Side Effect Information. IMBRUVICA (ibrutinib) is an oral, once-daily therapy. Understanding Mantle Cell Lymphoma (MCL). MCL) may seem overwhelming at first, but understanding it can help you feel more at ease. In MCL, the abnormal B cells crowd out healthy B cells. MCL is a type of B cell. Read more about MCL. IMBRUVICA ...

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What Is Chronic Lymphocytic Leukemia | IMBRUVICA® (ibrutinib)

https://www.imbruvica.com/cll

Important Side Effect Information. From IMBRUVICA access and affordability to nurse call support—we're here to help. Important Side Effect Information. YOU&i™ Support Program. Important Side Effect Information. IMBRUVICA (ibrutinib) is a once-daily, oral CLL medication with. Understanding Chronic Lymphocytic Leukemia (CLL). Researchers have come a long way in understanding how changes in the body’s cells occur in chronic lymphocytic leukemia. In CLL, abnormal. Abdominal pain or fullness. In a clinical tr...

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Enroll in YOU&I™ Patient Access Support | IMBRUVICA® (ibrutinib)

https://www.imbruvica.com/youandi

Important Side Effect Information. From IMBRUVICA access and affordability to nurse call support—we're here to help. Important Side Effect Information. YOU&i™ Support Program. Important Side Effect Information. Discover a world of support. Connect to personalized IMBRUVICA (ibrutinib) support: access, affordability, and nurse call support and resources. We provide personalized assistance to help you through your IMBRUVICA treatment journey by:. Providing educational resources about your disease. Month re...

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Patient Resources & Information for IMBRUVICA® (ibrutinib)

Important Side Effect Information. From IMBRUVICA access and affordability support options. To nurse call support—. We're here to help. Or learn more about the program. Important Side Effect Information. Previously Treated Mantle Cell Lymphoma. Previously Treated Marginal Zone Lymphoma. Previously Treated Chronic Graft Versus Host Disease. YOU&i™ Support Program. Important Side Effect Information. Has your doctor changed your. IMBRUVICA prescription to the new. Formulation of one pill, once a day? To vie...

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HCP Information for Once-Daily IMBRUVICA® (ibrutinib) | HCP

Register for More Information. See CLL/SLL Efficacy and Safety. Connect with Specialty Pharmacies for access to IMBRUVICA. Watch the MOA video to see how IMBRUVICA works. Learn about extended overall survival (OS) in CLL/SLL with IMBRUVICA. Visit the IMBRUVICA booth at upcoming conventions. Help your patients enroll with the YOU&i Support Program. See NCCN Guidelines that recommend IMBRUVICA for CLL/SLL patients. Register for More Information About IMBRUVICA. And click on the Privacy Policy. May increase...

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