Discussion of work in mitochondrial physiology and bioenergetics by <a href="http://systems-signals.blogspot.co.uk/">the Systems and Signals Group</a>
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Imperial Mitochondriacs | imperialmitochondriacs.blogspot.com Reviews
https://imperialmitochondriacs.blogspot.com
Discussion of work in mitochondrial physiology and bioenergetics by <a href="http://systems-signals.blogspot.co.uk/">the Systems and Signals Group</a>
imperialmitochondriacs.blogspot.com
Imperial Mitochondriacs: Prediction of multidimensional drug dose responses based on measurements of drug pairs
http://imperialmitochondriacs.blogspot.com/2016/09/prediction-of-multidimensional-drug.html
Discussion of work in mitochondrial physiology and bioenergetics by the Systems and Signals Group. Tuesday, 20 September 2016. Prediction of multidimensional drug dose responses based on measurements of drug pairs. Anat Zimmer, Itay Katzir, Erez Dekel, Avraham E. Mayo, and Uri Alon. Http:/ www.pnas.org/content/113/37/10442.full. Not mitochondrial, but very cool. Subscribe to: Post Comments (Atom). Follow us on Twitter: @IC mitochondria. Systems and Signals Group. Equal and Opposite Reaction.
Imperial Mitochondriacs: Mitochondrial Dysfunction Prevents Repolarization of Inflammatory Macrophages
http://imperialmitochondriacs.blogspot.com/2016/10/mitochondrial-dysfunction-prevents.html
Discussion of work in mitochondrial physiology and bioenergetics by the Systems and Signals Group. Tuesday, 18 October 2016. Mitochondrial Dysfunction Prevents Repolarization of Inflammatory Macrophages. Http:/ www.cell.com/cell-reports/supplemental/S2211-1247(16)31213-X. To become M1 (pro-inflammatory) cells, this process inhibits OXPHOS. The signal (IL-4) which induces M2 (anti-inflammatory) cells cannot reverse this suppression of OXPHOS, and so they remain trapped in the pro-inflammatory state...
Imperial Mitochondriacs: TCA Cycle and Mitochondrial Membrane Potential Are Necessary for Diverse Biological Functions
http://imperialmitochondriacs.blogspot.com/2016/01/tca-cycle-and-mitochondrial-membrane.html
Discussion of work in mitochondrial physiology and bioenergetics by the Systems and Signals Group. Wednesday, 13 January 2016. TCA Cycle and Mitochondrial Membrane Potential Are Necessary for Diverse Biological Functions. Http:/ www.sciencedirect.com/science/article/pii/S1097276515009363. Interestingly, treating the ATPIF1-KO cells with an antioxidant, which mops up ROS (canonically considered to be the bad-guy of mitochondrial physiology, see here. Subscribe to: Post Comments (Atom). Accurate concentrat...
Imperial Mitochondriacs: Loss of Dendritic Complexity Precedes Neurodegeneration in a Mouse Model with Disrupted Mitochondrial Distribution in Mature Dendrites
http://imperialmitochondriacs.blogspot.com/2016/10/loss-of-dendritic-complexity-precedes.html
Discussion of work in mitochondrial physiology and bioenergetics by the Systems and Signals Group. Tuesday, 11 October 2016. Loss of Dendritic Complexity Precedes Neurodegeneration in a Mouse Model with Disrupted Mitochondrial Distribution in Mature Dendrites. López-Doménech G, Higgs NF, Vaccaro V, Roš H, Arancibia-Cárcamo IL, MacAskill AF, Kittler JT. Http:/ www.cell.com/cell-reports/abstract/S2211-1247(16)31208-6. Subscribe to: Post Comments (Atom). Follow us on Twitter: @IC mitochondria.
Imperial Mitochondriacs: Evolution of Cell-to-Cell Variability in Stochastic, Controlled, Heteroplasmic mtDNA Populations
http://imperialmitochondriacs.blogspot.com/2016/11/evolution-of-cell-to-cell-variability.html
Discussion of work in mitochondrial physiology and bioenergetics by the Systems and Signals Group. Tuesday, 1 November 2016. Evolution of Cell-to-Cell Variability in Stochastic, Controlled, Heteroplasmic mtDNA Populations. Http:/ www.cell.com/ajhg/fulltext/S0002-9297(16)30397-4. Iain G. Johnston and Nick S. Jones. Why should we care about these cellular populations? And a preprint version can be viewed here. Crossed from Evolution, Energ. Subscribe to: Post Comments (Atom). Systems and Signals Group.
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19
Systems and Signals Group: How conserved are protein-protein interactions? And why would you want to know?
http://systems-signals.blogspot.com/2012/09/how-conserved-are-protein-protein.html
Systems and Signals Group. Our group studies disorder in Nature with an emphasis on networks and signals. Each of these blog articles introduces one of our recent published papers for the general reader. Friday, 21 September 2012. How conserved are protein-protein interactions? And why would you want to know? To say that two proteins are homologous means that they are similar through common evolutionary descent: in some sense, they are the 'same' protein). The answer, it is often assumed, is 'yes': a fai...
Systems and Signals Group: What's the difference? Telling apart two sets of signals
http://systems-signals.blogspot.com/2014/04/whats-difference-telling-apart-two-sets.html
Systems and Signals Group. Our group studies disorder in Nature with an emphasis on networks and signals. Each of these blog articles introduces one of our recent published papers for the general reader. Thursday, 10 April 2014. Telling apart two sets of signals. A) Comparing time series by alignment B) Comparing time series by their structural features: in this we probe many structural features of the time series simultaneously (ii) and then distil out the relevant ones (iii). Each of the dots correspon...
Systems and Signals Group: How evolution deals with mitochondrial mutants (and how we can take advantage)
http://systems-signals.blogspot.com/2015/06/how-evolution-deals-with-mitochondrial.html
Systems and Signals Group. Our group studies disorder in Nature with an emphasis on networks and signals. Each of these blog articles introduces one of our recent published papers for the general reader. Monday, 15 June 2015. How evolution deals with mitochondrial mutants (and how we can take advantage). Is it due to the decreased number of mtDNAs per cell, increasing the magnitude of genetic drift? Or does something occur during later development to induce the variability? Labels: approximate Bayesian c...
Systems and Signals Group: The function of mitochondrial networks
http://systems-signals.blogspot.com/2015/04/the-function-of-mitochondrial-networks.html
Systems and Signals Group. Our group studies disorder in Nature with an emphasis on networks and signals. Each of these blog articles introduces one of our recent published papers for the general reader. Monday, 27 April 2015. The function of mitochondrial networks. Mitochondria are dynamic energy-producing organelles, and there can be hundreds or even thousands of them in one cell. Mitochondria (as we've blogged about before - e.g. here. Nonlinear phenomena - like some percolation. Taking a mathematical...
imperialchemthermo.blogspot.com
Equal and Opposite Reaction: Optimal odour receptors
http://imperialchemthermo.blogspot.com/2016/02/optimal-odour-receptors.html
Equal and Opposite Reaction. Highlighting work related to the use of (bio)chemical reactions to achieve sophisticated behaviour such as sensing, signalling, inference, self-assembly and locomotion. Monday, 29 February 2016. By David Zwicker, Arvind Murugan and Michael P. Brenner discusses the optimal setup of receptors from an information-theoretic perspective. 1) Any given receptor should be active half the time, which maximises the amount of information provided by that receptor in isolation.
imperialchemthermo.blogspot.com
Equal and Opposite Reaction: September 2015
http://imperialchemthermo.blogspot.com/2015_09_01_archive.html
Equal and Opposite Reaction. Highlighting work related to the use of (bio)chemical reactions to achieve sophisticated behaviour such as sensing, signalling, inference, self-assembly and locomotion. Sunday, 13 September 2015. Shameless self-promotion: Engineering self-assembly pathways. Over the last two weeks we've finally managed to get our paper on self-assembly pathways. Published in Nature ("we" includes the Turberfield. Subscribe to: Posts (Atom). Follow us on twitter. Cellular readouts (orange) can...
imperialchemthermo.blogspot.com
Equal and Opposite Reaction: A simple biomolecular machine for exploiting information
http://imperialchemthermo.blogspot.com/2017/01/a-simple-biomolecular-machine-for.html
Equal and Opposite Reaction. Highlighting work related to the use of (bio)chemical reactions to achieve sophisticated behaviour such as sensing, signalling, inference, self-assembly and locomotion. Wednesday, 11 January 2017. A simple biomolecular machine for exploiting information. Http:/ journals.aps.org/prl/abstract/10.1103/PhysRevLett.118.028101. Phosphate) there are two phosphates in the chain; in ATP( Adenosine tr. Phosphate) there are three. There’s still a lot to do on this subject; we have...
imperialchemthermo.blogspot.com
Equal and Opposite Reaction: About Us
http://imperialchemthermo.blogspot.com/p/im-thomas-ouldridge.html
Equal and Opposite Reaction. Highlighting work related to the use of (bio)chemical reactions to achieve sophisticated behaviour such as sensing, signalling, inference, self-assembly and locomotion. This blog is managed by Thomas Ouldridge. A Royal Society University Research Fellow in the Bioengineering Department at Imperial College, London. Contributors include students and collaborators. Subscribe to: Posts (Atom). Follow us on twitter. Systems and Signals Group. Blank On The Map.
imperialchemthermo.blogspot.com
Equal and Opposite Reaction: January 2017
http://imperialchemthermo.blogspot.com/2017_01_01_archive.html
Equal and Opposite Reaction. Highlighting work related to the use of (bio)chemical reactions to achieve sophisticated behaviour such as sensing, signalling, inference, self-assembly and locomotion. Wednesday, 11 January 2017. A simple biomolecular machine for exploiting information. Http:/ journals.aps.org/prl/abstract/10.1103/PhysRevLett.118.028101. Phosphate) there are two phosphates in the chain; in ATP( Adenosine tr. Phosphate) there are three. There’s still a lot to do on this subject; we have...
Systems and Signals Group: Inferring the evolutionary history of photosynthesis : C 4 yourself
http://systems-signals.blogspot.com/2013/10/inferring-evolutionary-history-of.html
Systems and Signals Group. Our group studies disorder in Nature with an emphasis on networks and signals. Each of these blog articles introduces one of our recent published papers for the general reader. Tuesday, 1 October 2013. Inferring the evolutionary history of photosynthesis : C 4 yourself. Our (open access) paper is. And there's a less technical summary and commentary. Posted by Systems and Signals Group. Subscribe to: Post Comments (Atom). Interpretations of Famous Songs with Simple Cartoons.
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imperialmitochondriacs.blogspot.com
Imperial Mitochondriacs
Discussion of work in mitochondrial physiology and bioenergetics by the Systems and Signals Group. Wednesday, 7 December 2016. Selective removal of deletion-bearing mitochondrial DNA in heteroplasmic Drosophila. Http:/ www.nature.com/articles/ncomms13100. Nikolay P. Kandul, Ting Zhang, Bruce A. Hay and Ming Guo. What is the tradeoff that keeps mitophagy low? Tuesday, 1 November 2016. Evolution of Cell-to-Cell Variability in Stochastic, Controlled, Heteroplasmic mtDNA Populations. Mitochondrial DNA (mtDNA...
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