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Isofol Medical AB

Isofol Medical AB

http://www.isofolmedical.com/

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PAGE TITLE
Isofol Medical AB | isofolmedical.com Reviews
<META>
DESCRIPTION
Isofol Medical AB
<META>
KEYWORDS
1 Isofol
2 isofol medical
3 modufolin
4 folates
5 folic acid
6 methylene tetrahydrofolate
7 methylenetetrahydrofolate
8 MTHF
9 tetrahydrofolate
10 methyltetrahydrofolate
CONTENT
Page content here
KEYWORDS ON
PAGE
the company,partners,modufolin,investors,news and press,isofol medical,full story,modufolin development,stay informed,clinical trials,clinical trials gov,development pipeline
CONTENT-TYPE
utf-8
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Isofol Medical AB | isofolmedical.com Reviews

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Isofol Medical AB

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isofolmedical.com isofolmedical.com
1

News & press > First patient successfully treated with Modufolin® as a rescue therapy with high dose methotrexate (HDMTX) treatment in Osteosarcoma.

http://www.isofolmedical.com/press/read/15-04-14/First_patient_successfully_treated_with_Modufolin®_as_a_rescue_therapy_with_high_dose_methotrexate_HDMTX_treatment_in_Osteosarcoma.aspx

First patient successfully treated with Modufolin as a rescue therapy with high dose methotrexate (HDMTX) treatment in Osteosarcoma. April 14, 2015. Said Anders Rabbe, CEO of Isofol Medical. Modufolin (chemical name [6R]-5,10-methylenetetrahydrofolate), is a novel folate-based compound developed to increase the efficacy and reduce the side effects of antimetabolites used in cancer treatment. It is the key active metabolite of all clinically used folate-based drugs today including leucovorin and levol...

2

About Isofol Medical

http://www.isofolmedical.com/about.aspx

A research and development company. To strengthen the development program of Modufolin , Isofol formed a collaboration with Recipharm to exclusively manufacture Modufolin in 2014. At the same time in 2014 Recipharm Venture Fund invested SEK 8 million in Isofol. Recipharm venture is a life science sector investor with a strategic interest in pharmaceutical and biotechnology companies in need of pharmaceutical development and manufacturing support. After establishing that the active metabolite in LV was MT...

3

Investors

http://www.isofolmedical.com/investors.aspx

Isofol Medical is a clinical stage pharmaceutical company working to enhance oncology therapies by developing novel anticancer products where there is a large unmet need. Isofol's lead clinical candidate Modufolin ([6R] 5,10-methylene tetrahydrofolate) has been developed to increase the efficacy and decrease the side effects of chemotherapy treatment of solid tumors. Isofol collaborates closely with its strategic R&D partner Merck Millipore, the world's leading manufacturer of reduced folates inc...

4

Modufolin®

http://www.isofolmedical.com/modufolin.aspx

By adding folates like leucovorin or levoleucovorin to the 5-FU treatment, response rates were increased from around 10% to 30%. Isofol concludes that the reason for the limited response rate of this combination treatment is largely due to the fact that many patients cannot metabolize leucovorin or levoleucovorin into the key active metabolite ‘methylentetrahydrofolate’. It is this methylentetrahydrofolate that interacts with 5-FU and increases the response rate. Isofol intends to take Modufolin to proof...

5

News & press

http://www.isofolmedical.com/press.aspx

Isofol Medical has successfully advanced to the next dose level of Modufolin in a phase I/II clinical trial in colorectal cancer. June 02, 2016. Isofol announces successful meetings with European and US regulatory authorities regarding the design of a pivotal Phase II clinical trial of Isofol’s lead Drug candidate, Modufolin. May 24, 2016. Isofol Medical share issue oversubscribed, securing over SEK 39 million to strengthen the ongoing Phase II clinical development program of Modufolin. March 14, 2016.

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sagehealthcare.com sagehealthcare.com

About - Sage Healthcare

http://www.sagehealthcare.com/news/284

GLOBAL HEALTHCARE TRANSACTIONS AND BUSINESS STRATEGY. Sage Group Advises P. Sage and Talentmark . Isofol Appoints The . Isofol Appoints The Sage Group to Identify Strategic Partnerships for its Novel Modufolin Chemotherapy Asset. Isofol Appoints The Sage Group to Identify Strategic Partnerships for its Novel Modufolin Chemotherapy Asset. Gothenburg, Sweden, Cambridge UK, and Clinton NJ. Isofol ( www.isofolmedical.com. About The Sage Group, Inc. Dr W T. Mason. Director, Sage Healthcare. Tel: 1 908 2306170.

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Isofol is a clinical stage pharmaceutical company developing novel products for unmet needs within oncology. Isofol’s lead clinical candidate, Modufolin , is predicted to improve the outlook for cancer patients undergoing chemotherapy treatment with a range of antimetabolites. Isofol’s ongoing clinical trials are focusing on colorectal cancer and osteosarcoma. Isofol collaborates closely with its strategic R&D partner Merck Millipore, the world’s leading manufacturer of reduced folates. Patent covering t...

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Isofol Medical AB

Isofol is a clinical stage pharmaceutical company developing novel products for unmet needs within oncology. Isofol’s lead clinical candidate, Modufolin , is predicted to improve the outlook for cancer patients undergoing chemotherapy treatment with a range of antimetabolites. Isofol’s ongoing clinical trials are focusing on colorectal cancer and osteosarcoma. Isofol collaborates closely with its strategic R&D partner Merck Millipore, the world’s leading manufacturer of reduced folates. Patent covering t...

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Isofol is a clinical stage pharmaceutical company developing novel products for unmet needs within oncology. Isofol’s lead clinical candidate, Modufolin , is predicted to improve the outlook for cancer patients undergoing chemotherapy treatment with a range of antimetabolites. Isofol’s ongoing clinical trials are focusing on colorectal cancer and osteosarcoma. Isofol collaborates closely with its strategic R&D partner Merck Millipore, the world’s leading manufacturer of reduced folates. Patent covering t...

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