jeanzhao.dfci.harvard.edu

The Zhao Lab

This is the Zhao lab. The work of our laboratory integrates molecular biology, tissue engineering and novel mouse models of human cancer to study oncogenic alterations in kinases that are involved in tumor formation and metastasis. Dr Jean Zhao's lab. PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting. MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells. Find contact information and meet the members of the Zhao Lab.

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The Zhao Lab | jeanzhao.dfci.harvard.edu Reviews

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This is the Zhao lab. The work of our laboratory integrates molecular biology, tissue engineering and novel mouse models of human cancer to study oncogenic alterations in kinases that are involved in tumor formation and metastasis. Dr Jean Zhao's lab. PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting. MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells. Find contact information and meet the members of the Zhao Lab.

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9 featured publications

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The Zhao Lab | jeanzhao.dfci.harvard.edu Reviews

https://jeanzhao.dfci.harvard.edu

This is the Zhao lab. The work of our laboratory integrates molecular biology, tissue engineering and novel mouse models of human cancer to study oncogenic alterations in kinases that are involved in tumor formation and metastasis. Dr Jean Zhao's lab. PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting. MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells. Find contact information and meet the members of the Zhao Lab.

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jeanzhao.dfci.harvard.edu

1

Zhao Lab Members

http://jeanzhao.dfci.harvard.edu/people.php

Jean Zhao, Ph.D. Biological Chemistry and Molecular Pharmacology. Harvard Medical School and Dana-Farber Cancer Institute. Jean Zhao@dfci.harvard.edu. Kekui ledward@dfci.harvard.edu. KayleyN Abell-Hart@dfci.harvard.edu. Thanh Barbie, M.D. Johann Bergholz, Ph.D. Johann Bergholz@dfci.harvard.edu. Haley Brinjones@dfci.harvard.edu. Shandon Coffman@dfci.harvard.edu. Liya Ding, Ph.D. Liya ding@dfci.harvard.edu. Sheilac drakeley@dfci.harvard.edu. Shom Goel, M.D., Ph.D. Shom goel@dfci.harvard.edu.

2

Zhao Publications

http://jeanzhao.dfci.harvard.edu/publications.php

Mitotic MELK-eIF4B signaling controls protein synthesis and tumor cell survival. Wang Y, Begley M, Li Q, Huang H-T, Lako A, Eck MJ, Gray NS, Mitchison TJ, Cantley LC, Zhao JJ. Proc Natl Acad Sci USA. 2016 July 7; 113(35):9810-5. Combination inhibition of PI3K and mTORC1 yields durable remissions in mice bearing orthotopic patient-derived xenografts of HER2-positive breast cancer brain metastases. 2016 22(7):723-6. Published online, 2016 June 6. 2016 Mar 14; 29(3):255 269. Wang Q, Liu P, Spangle JM, Von T...

3

Lab News

http://jeanzhao.dfci.harvard.edu/news.php

July 13, 2016. Dr Ni's recent Nature Medicine article made it to the cover of their July edition. Congratulations! See the cover art in our "Publications". Artwork by Erin Dewalt and Susanne Ramm. Congratulations! June 30, 2016. Shane O'Neal is leaving the Zhao Lab for graduate studies at Duke University in the fall. Best wishes, Shane! February 9, 2016. Dr Shom Goel's manuscript entitled Overcoming Therapeutic Resistance in HER2-Positive Breast Cancers with CDK4/6 Inhibitors. October 28, 2015. Dr Jing N...

4

The Zhao Lab

http://jeanzhao.dfci.harvard.edu/index.php

This is the Zhao lab. August 16, 2016. Dr Johann Bergholz received a Postdoctoral Fellowship from the Susan G. Komen Foundation to support his research project entitled "Development of PI3Kß-based combination therapies in PTEN-deficient breast cancer". Congratulations, Dr. Bergholz! Dr Ni's recent Nature Medicine article made it to the cover of their July edition. Congratulations! See the cover art in our "Publications". Artwork by Erin Dewalt and Susanne Ramm. July 13, 2016. July 12, 2016. July 5, 2016.

5

Links

http://jeanzhao.dfci.harvard.edu/links.php

Dana-Farber/Harvard Cancer Center (DF/HCC) is the largest comprehensive cancer center in the world, bringing together the cancer research efforts of our seven member institutions: Beth Israel Deaconess Medical Center, Brigham and Women's Hospital, Children's Hospital Boston, Dana-Farber Cancer Institute, Harvard Medical School, Harvard School of Public Health, and Massachusetts General Hospital. Division of Medical Sciences, Harvard Medical School. National Center for Biotechnology Information. We are pa...

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cancerbiology.dfci.harvard.edu

Cancer Biology Labs

http://cancerbiology.dfci.harvard.edu/laboratories.php

Department of Cancer Biology. Rameen Beroukhim, M.D., Ph.D. Stephen C. Blacklow, M.D., Ph.D. Nika N. Danial, Ph.D. Michael J. Eck, M.D., Ph.D. Ulrike S. Eggert, Ph.D. Suzanne Gaudet, Ph.D. Alexander Gimelbrant, Ph.D. Nathanael S. Gray, Ph.D. J Dirk Iglehart, M.D. David M. Livingston, M.D. Qiufu Ma, Ph.D. Jarrod Marto, Ph.D. Yoshihiro Nakatani, Ph.D. Pere Puigserver, Ph.D. Thomas M. Roberts, Ph.D., Co-Chair. Rosalind Segal, M.D., Ph.D. William M. Shih, Ph.D. Peter Sicinski, M.D., Ph.D. Marc Vidal, Ph.D.

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Collaborators |

http://pentelutelabmit.com/collaborators

MIT, Cambridge, MA. The Buchwald Research Group. MIT, Cambridge, MA. MIT, Cambridge, MA. The Johnson Research Group. MIT, Cambridge, MA. Klavs F. Jensen Research Group. MIT, Cambridge, MA. Prof Troy Van Voorhis. MIT, Cambridge, MA. Prof K. Dane Wittrup. MIT, Cambridge, MA. Chemical Engineering, Stanford, CA. Children’s Hospital, Boston, MA. Lencer Lab @ Boston Children’s Hospital. University of Kansas Medical School. Kansas City, KS. Prof R. John Collier. Harvard Medical School, Boston, MA.

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The Zhao Lab

This is the Zhao lab. The work of our laboratory integrates molecular biology, tissue engineering and novel mouse models of human cancer to study oncogenic alterations in kinases that are involved in tumor formation and metastasis. Dr Jean Zhao's lab. PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting. MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells. Find contact information and meet the members of the Zhao Lab.

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