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Thomas Group Web Pages. The group works on two overlapping areas:. Find out more from our Twitter feed: @GroupThomas.

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Thomas Group Web Pages. The group works on two overlapping areas:. Find out more from our Twitter feed: @GroupThomas.
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https://jim-thomas.staff.shef.ac.uk

Thomas Group Web Pages. The group works on two overlapping areas:. Find out more from our Twitter feed: @GroupThomas.

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jim-thomas.staff.shef.ac.uk jim-thomas.staff.shef.ac.uk
1

Current group members

http://jim-thomas.staff.shef.ac.uk/The_Thomas_Group/People.html

For his PhD project Paul is looking at therapeutic leads based on hetero-bimetallic metal complexes. At other times, he’s probably in the gym. Thanks to the Leverhulme Trust, Mike is carrying out postdoctoral research into self-assembled hosts for biomolecules. Mike must be a sucker for punishment as he did his PhD in the Thomas group. Help I can’t escape’. Hiwa’s PhD project, which is funded by Kurdistan Regional Government. She isn’t always this excited about chemistry. Rachel has to deal with three Ph...

2

Targeting biomolecules

http://jim-thomas.staff.shef.ac.uk/The_Thomas_Group/Targeting_biomolecules.html

We are designing luminescent metal complexes and small molecules to target biomolecules and specific structures within cells. These compounds can be used as structural probes for a range of state-of-the-art microscopy techniques, including confocal microscopy and transmission electron microscopy. By careful selection of the chemical and physical properties of the compounds, we are also producing new therapeutic leads. Nuclear DNA of living cells stained red. Structure of a quadruplex DNA bound complex.

3

Self-assembly

http://jim-thomas.staff.shef.ac.uk/The_Thomas_Group/Self-assembly.html

We are looking at self-assembly using electrochemically and photochemically active ruthenium(II) building blocks. We do this by either self-assembling kinetically inert metal building blocks or using relatively labile ruthenium(II) centres as the assembler. The final multinuclear assemblies are being targeted as sensors for ions, molecules, and biomolecules, or can function as new paradigms for molecular devices. A self-assembled Ru 2. Luminescent sensor for ATP. A trinuclear Ru (II).

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Collaborations

http://molecular-modeling.dq.ua.pt/collaborations.html

Here we present the main collaborations of the Molecular Modeling group around the world. Professor Philip A. Gale. Univeristy of Southampton LINK. What we do: Molecular dynamics simulation of transmembrane anion transport by synthetic receptors. Professor Paul D. Beer. Department of Chemistry, University of Oxford LINK. What we do: Computational investigation of the functional properties and energetics of anion templated interlocked systems including rotaxanes, catenanes and interpenetrated capsules.

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