heterocyclist.com
Just look at the structure of this alkaloid! | The Heterocyclist
https://heterocyclist.com/2013/01/28/just-look-at-the-structure-of-this-alkaloid
A blog about heterocyclic chemistry. January 28, 2013. Just look at the structure of this alkaloid! Sometimes you just have to step back and marvel at the structures that are found in nature. Check out zamamiphidin A, a new manzamine alkaloid isolated from an Okinawan sponge by J. Kobayashi and co-workers ( Organic Letters. Heptacyclic. Quaternary ammonium. Massively bridged. Well done, sponges! Laquo; Previous post. Next post ». 7 responses to “Just look at the structure of this alkaloid! I guess when y...
heterocyclist.com
Uncategorized | The Heterocyclist
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A blog about heterocyclic chemistry. RSS for this section. April 29, 2013. Pd(II)-Catalyzed Dehydrogenative Cyclizations of. Near-simultaneous reports of an interesting new pyrrole (and dihydropyrrole) synthesis have appeared recently from the labs of Frank Glorius (Westfälische Wilhelms-Universität Münster). And Naohiko Yoshikai (Nanyang Technologial University, Singapore). The scope of the reaction is decent, as indicated below. Failures include R. Or cyclopropyl and R. February 4, 2013. I keep it upda...
heterocyclist.com
Pd(II)-Catalyzed Dehydrogenative Cyclizations of N-Allylimines | The Heterocyclist
https://heterocyclist.com/2013/04/29/pdii-catalyzed-dehydrogenative-cyclizations-of-n-allylimines
A blog about heterocyclic chemistry. April 29, 2013. Pd(II)-Catalyzed Dehydrogenative Cyclizations of. Near-simultaneous reports of an interesting new pyrrole (and dihydropyrrole) synthesis have appeared recently from the labs of Frank Glorius (Westfälische Wilhelms-Universität Münster). And Naohiko Yoshikai (Nanyang Technologial University, Singapore). The scope of the reaction is decent, as indicated below. Failures include R. Or cyclopropyl and R. Cinnamyl imines were also unsuccessful. Notify me of n...
commonorganicchemistry.com
Organic Chemistry Resources
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Sr R&D Scientist (Cody Labs). Research Scientist I (AMRI). Only search this site. NMR Residual Solvent(s) Calculator. Myers - Solvent Properties. Gottlieb - NMR Residual Peaks (2010). Evans - pKa Table. Baran - Essentials of Heterocyclic Chemistry I. Baran - Essentials of Heterocyclic Chemistry II. Baran - Essentials of Heterocyclic Chemistry III. Baran - Essentials of Heterocyclic Chemistry IV. How to Get a Summer Internship in Organic Chemistry.
heterocyclist.com
Name Reactions | The Heterocyclist
https://heterocyclist.com/category/name-reactions
A blog about heterocyclic chemistry. RSS for this section. August 6, 2015. Regioselective synthesis of 3- and 5-aminopyrazoles. Just a bit of sodium ethoxide does the trick …. Wouldn’t it be nice to be able to produce either the 3- or 5-aminopyrazole regioisomer in a selective fashion? From Boehringer Ingelheim is a most welcome arrival. Heating the nitrile 3. With the alkyl-substituted hydrazine 4. In ethanol produces the 5-aminopyrazole 7. Presumably through the adduct 5. Should be larger than k. Fandr...
heterocyclist.com
Oldies-But-Goodies | The Heterocyclist
https://heterocyclist.com/category/oldies-but-goodies
A blog about heterocyclic chemistry. RSS for this section. August 6, 2015. Regioselective synthesis of 3- and 5-aminopyrazoles. Just a bit of sodium ethoxide does the trick …. Wouldn’t it be nice to be able to produce either the 3- or 5-aminopyrazole regioisomer in a selective fashion? From Boehringer Ingelheim is a most welcome arrival. Heating the nitrile 3. With the alkyl-substituted hydrazine 4. In ethanol produces the 5-aminopyrazole 7. Presumably through the adduct 5. Should be larger than k. Fandr...
heterocyclist.com
The Heterocyclist | A blog about heterocyclic chemistry | Page 2
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A blog about heterocyclic chemistry. October 21, 2012. How did this slip by the referees? Azomethine imines are not azomethine ylides. A recent paper by Xingwei Li and co-workers in Angewandte Chemie International Edition has some nice chemistry in it, but take a look at the title, “ Rhodium(III)-catalyzed oxidative C-H functionalization of azomethine ylides. 8221; One might expect to see some azomethine ylides, right? No, they are azomethine imines:. Edit: Here’s another paper from the same lab. Species...
heterocyclist.com
Drugs | The Heterocyclist
https://heterocyclist.com/category/drugs
A blog about heterocyclic chemistry. RSS for this section. February 4, 2013. Short Course: “Heterocyclic Chemistry – A Drug-Oriented Approach”. Interested in having a short course on Heterocyclic Chemistry at your company? In late 2011, I put together a new two-day short course entitled Heterocyclic Chemistry – A Drug-Oriented Approach. To present at companies. In a nutshell, it’s an intensive, preparatively-oriented. I keep it updated with lots of current chemistry. January 7, 2013. Here’s a process tha...
heterocyclist.com
On the regioselectivity of metal-catalyzed functionalizations of heteroaromatic C-H bonds | The Heterocyclist
https://heterocyclist.com/2012/07/11/on-the-regioselectivity-of-metal-catalyzed-functionalizations-of-heteroaromatic-ch-bonds
A blog about heterocyclic chemistry. July 11, 2012. In Reactions of Heterocycles. On the regioselectivity of metal-catalyzed functionalizations of heteroaromatic C-H bonds. A recent paper by Daniel Ess and co-workers at BYU ( Organic Letters. Moves us closer to that goal. Let’s say you’re in the drug discovery business and would like to snap a bunch of different arenes onto a core structure. Where will they go? Regioselectivity is often high (c.f. the example from Lapointe, Fagnou, and co-workers. Cited ...
