KIN-DRIVER.LELOIR.ORG.AR

Kin-driver

Help us, Help you! Kin-Driver - A human kinase database with driver mutations. Mutations leading to activation of proto-oncogenic protein kinases (PKs) are crucial for understanding tumorigenesis and as targets for anti-tumor drugs. However, bionformatics tools developed so far to differentiate driver mutations, that are usually based on conservation or functional considerations, repeteadly fail to predict the effects of activating mutations. Protein Name, Gene Name, Synonims:.

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Kin-driver | kin-driver.leloir.org.ar Reviews

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Help us, Help you! Kin-Driver - A human kinase database with driver mutations. Mutations leading to activation of proto-oncogenic protein kinases (PKs) are crucial for understanding tumorigenesis and as targets for anti-tumor drugs. However, bionformatics tools developed so far to differentiate driver mutations, that are usually based on conservation or functional considerations, repeteadly fail to predict the effects of activating mutations. Protein Name, Gene Name, Synonims:.

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Kin-driver | kin-driver.leloir.org.ar Reviews

https://kin-driver.leloir.org.ar

Help us, Help you! Kin-Driver - A human kinase database with driver mutations. Mutations leading to activation of proto-oncogenic protein kinases (PKs) are crucial for understanding tumorigenesis and as targets for anti-tumor drugs. However, bionformatics tools developed so far to differentiate driver mutations, that are usually based on conservation or functional considerations, repeteadly fail to predict the effects of activating mutations. Protein Name, Gene Name, Synonims:.

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kin-driver.leloir.org.ar

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Kin-driver

http://kin-driver.leloir.org.ar/download.php

Help us, Help you! Kin-Driver - A human kinase database with driver mutations. Here we provide the complete Kin-Driver database as a MySQL package. You must have installed a MySQL server on your computer. You can found the database schema here. You can download Kin-Driver using the following links:. Kin Driver based on COSMIC v70. Quick Instructions for Installation. Log into your MySQL account:. Command to build the database like this:. Here we provide a link to the list of driver mutations.

2

Kin-driver

http://kin-driver.leloir.org.ar/helpus.php

Help us, Help you! Kin-Driver - A human kinase database with driver mutations. Help us, help you! If you know a driver mutation and want to report it, please complete the next form. You need to provide a pubmed id where we can corroborate it is a driver mutation. We will be happy to review it and add it to the database. Protein Name or Gene Name:.

3

Kin-driver

http://kin-driver.leloir.org.ar/help.php

Help us, Help you! Kin-Driver - A human kinase database with driver mutations. Kin-driver can be searched using the tabs at the left menu in the Home page. The result is a list of UniProt IDs, where the last column of the table indicates how many mutations are in Kin-Driver for that protein. In this case, position 724 for EGFR HUMAN yields no results, but an equivalent mutated position is found in ALK HUMAN, correponding to the G1128A mutation. Browsing by tissue displays the tissue types that correspond...

4

Kin-driver

http://kin-driver.leloir.org.ar/references.php

Help us, Help you! Kin-Driver - A human kinase database with driver mutations. 1] Kin-Driver: a Database of Driver Mutations in Protein Kinases. Franco L. Simonetti, Cristian Tornador, Nuria Nabau-Moretó, Miguel A. Molina-Vila, and Cristina Marino-Buslje. Database (Oxford). 2014; 2014: bau104. 2] Activating Mutations Cluster in the "Molecular Brake" Regions of Protein Kinases and do not Associate with Conserved or Catalytic Residues, Molina-Vila et al, 2013.

5

Kin-driver

http://kin-driver.leloir.org.ar/index.php

Help us, Help you! Kin-Driver - A human kinase database with driver mutations. Mutations leading to activation of proto-oncogenic protein kinases (PKs) are crucial for understanding tumorigenesis and as targets for anti-tumor drugs. However, bionformatics tools developed so far to differentiate driver mutations, that are usually based on conservation or functional considerations, repeteadly fail to predict the effects of activating mutations. Protein Name, Gene Name, Synonims:.

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docm.genome.wustl.edu

DoCM - Database of Curated Mutations

http://docm.genome.wustl.edu/news

Major website update. A new importing system. Was implemented to facilitate batch imports. This streamlines the import process and is documented in the batch submission help. Page The database was reorganized in to batches and reprocessed through the new automated importer. Database update. Kin-driver. And pan-cancer recurrent hotspots. Variants were added to DoCM. Database update. Automatic importer implemented to automatically import relevant variants from CIViC. DoCM cited by Krogan, N. J., Li...DoCM ...

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kin-driver.leloir.org.ar

Kin-driver

Help us, Help you! Kin-Driver - A human kinase database with driver mutations. Mutations leading to activation of proto-oncogenic protein kinases (PKs) are crucial for understanding tumorigenesis and as targets for anti-tumor drugs. However, bionformatics tools developed so far to differentiate driver mutations, that are usually based on conservation or functional considerations, repeteadly fail to predict the effects of activating mutations. Protein Name, Gene Name, Synonims:.

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