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Research | Klemke Lab

Human tumor cells (red) grow and induce a vascular supply (green) in live, optically transparent zebrafish. Our major research objective. Is to understand how human cancer develops and spreads through the body's circulation ( cell metastasis. And to use this information to design novel immune therapies and pharmaceuticals to eradicate primary and secondary metastatic tumors. Transparent animals open the window to view tumor formation, angiogenesis, and metastasis:. Genetic knockdown of PEAK1 tyrosine kin...

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Research | Klemke Lab | klemkelab.ucsd.edu Reviews
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Human tumor cells (red) grow and induce a vascular supply (green) in live, optically transparent zebrafish. Our major research objective. Is to understand how human cancer develops and spreads through the body's circulation ( cell metastasis. And to use this information to design novel immune therapies and pharmaceuticals to eradicate primary and secondary metastatic tumors. Transparent animals open the window to view tumor formation, angiogenesis, and metastasis:. Genetic knockdown of PEAK1 tyrosine kin...
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Research | Klemke Lab | klemkelab.ucsd.edu Reviews

https://klemkelab.ucsd.edu

Human tumor cells (red) grow and induce a vascular supply (green) in live, optically transparent zebrafish. Our major research objective. Is to understand how human cancer develops and spreads through the body's circulation ( cell metastasis. And to use this information to design novel immune therapies and pharmaceuticals to eradicate primary and secondary metastatic tumors. Transparent animals open the window to view tumor formation, angiogenesis, and metastasis:. Genetic knockdown of PEAK1 tyrosine kin...

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klemkelab.ucsd.edu klemkelab.ucsd.edu
1

Research | Klemke Lab

http://klemkelab.ucsd.edu/node/1

Human tumor cells (red) grow and induce a vascular supply (green) in live, optically transparent zebrafish. Our major research objective. Is to understand how human cancer develops and spreads through the body's circulation ( cell metastasis. And to use this information to design novel immune therapies and pharmaceuticals to eradicate primary and secondary metastatic tumors. Transparent animals open the window to view tumor formation, angiogenesis, and metastasis:. Genetic knockdown of PEAK1 tyrosine kin...

2

Contact | Klemke Lab

http://klemkelab.ucsd.edu/node/8

Richard Klemke, Ph.D. La Jolla, CA 92093. PHONE NUMBER: 858 - 822 - 5610.

3

Dr. Klemke | Klemke Lab

http://klemkelab.ucsd.edu/node/2

Professor, Department of Pathology and Moores Cancer Center.

4

Research | Klemke Lab

http://klemkelab.ucsd.edu/node/9

Transparent animals open the window to view tumor formation, angiogenesis, and metastasis: Several research projects are underway that use these unique models of tumor formation and metastasis:. Figure 1. Cx43 expression pattern in brain metastases from breast cancer patients. Epifluorescent photomicrographs of a surgically resected brain metastasis from a breast cancer patient triple stained for ( A. Nuclei (DAPI, blue), ( B. Cx43 (red), and ( C. The glial cell marker protein GFAP (green). ( D. Stoletov...

5

Research | Klemke Lab

http://klemkelab.ucsd.edu/node/11

Cancer Therapeutics and Chemoresistance:. Several research projects are underway to identify lead compounds and investigate the mechanisms of drug action and chemoresistance:. Figure 1. Hypusine modification of eIF5A. The polyamine biosynthesis pathway mediates the generation of spermidine from arginine, a dietary precursor of polyamines. Hypusination involves two sequential enzymatic reactions. DHPS ( d. Figure 2. Immunohistochemical staining of eIF5A1 (A), eIF5A2 (B) and Hyp-eIF5A1 (C) in normal hu...

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Conference Speakers

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Weizmann Institute, Israel. Http:/ www.weizmann.ac.il/immunology/AlonCV.html. University of California, San Francisco. Http:/ dentistry.ucsf.edu/barber/. Harvard University Medical School. Http:/ brugge.med.harvard.edu/. University of Oxford, UK. Http:/ www.bioch.ox.ac.uk/aspsite/research/brochure/Campbell/. Albert Einstein College of Medicine. Http:/ asb.aecom.yu.edu/faculty/condeelis john/? Leicester University, UK. Http:/ www.le.ac.uk/by/staff/drc/drc.html. Http:/ lccb.scripps.edu/. Http:/ www.wis...

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Research Opportunities in the Gonias Laboratory

http://goniaslab.ucsd.edu/Pages/positions.aspx

Turn on more accessible mode. Skip to main content. Turn off more accessible mode. Visit the Department of Pathology. Explore other UCSD Health Sciences sites. UC San Diego Health. UCSD School of Medicine. UC San Diego Health Sciences. UC San Diego Moores Cancer Center. About the Gonias Lab. About the Gonias Lab. Research Opportunities in the Gonias Laboratory. We are seeking highly motivated and dedicated postdoctoral fellows. About the Gonias Lab.

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About the GoniasLab - Steve Gonias, MD, PHD

http://goniaslab.ucsd.edu/about/Pages/default.aspx

Turn on more accessible mode. Skip to main content. Turn off more accessible mode. About the Gonias Lab. This Site: About the Gonias Lab. Visit the Department of Pathology. Explore other UCSD Health Sciences sites. UC San Diego Health. UCSD School of Medicine. UC San Diego Health Sciences. UC San Diego Moores Cancer Center. About the Gonias Lab. About the Gonias Lab. About the Gonias Lab. About the Gonias Lab. Steve Gonias Laboratory 9500 Gilman Drive, La Jolla, CA 92093-0612 (858) 534-0455.

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Steve Gonias - Published Research Papers from the Gonias Lab

http://goniaslab.ucsd.edu/Pages/publications.aspx

Turn on more accessible mode. Skip to main content. Turn off more accessible mode. Visit the Department of Pathology. Explore other UCSD Health Sciences sites. UC San Diego Health. UCSD School of Medicine. UC San Diego Health Sciences. UC San Diego Moores Cancer Center. About the Gonias Lab. About the Gonias Lab. Representative Research Publications from Gonias Laboratory. Shi, Y., Mantuano, E., Inoue, G., Campana, W.M., and Gonias, S.L. Myeloid cell receptor LRP1/CD91 regulates monocyte recruitment and ...

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Research | Klemke Lab

Human tumor cells (red) grow and induce a vascular supply (green) in live, optically transparent zebrafish. Our major research objective. Is to understand how human cancer develops and spreads through the body's circulation ( cell metastasis. And to use this information to design novel immune therapies and pharmaceuticals to eradicate primary and secondary metastatic tumors. Transparent animals open the window to view tumor formation, angiogenesis, and metastasis:. Genetic knockdown of PEAK1 tyrosine kin...

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