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The Laboratory of Human Genetic Diversity (LDGH) overarching goal is to enhance our understanding of genetic diversity and the genetic bases of complex traits and diseases in native and admixed populations from Latin America. We integrate concepts and tools of population genetics, genetic epidemiology, computational biology and functional genetics to achieve this goal. We are located at the Department of Biology. Of the Federal University of Minas Gerais. We were at the SMBE 2015 in Vienna (July 12-16th).

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The Laboratory of Human Genetic Diversity (LDGH) overarching goal is to enhance our understanding of genetic diversity and the genetic bases of complex traits and diseases in native and admixed populations from Latin America. We integrate concepts and tools of population genetics, genetic epidemiology, computational biology and functional genetics to achieve this goal. We are located at the Department of Biology. Of the Federal University of Minas Gerais. We were at the SMBE 2015 in Vienna (July 12-16th).
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The Laboratory of Human Genetic Diversity (LDGH) overarching goal is to enhance our understanding of genetic diversity and the genetic bases of complex traits and diseases in native and admixed populations from Latin America. We integrate concepts and tools of population genetics, genetic epidemiology, computational biology and functional genetics to achieve this goal. We are located at the Department of Biology. Of the Federal University of Minas Gerais. We were at the SMBE 2015 in Vienna (July 12-16th).

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1

Bioinformatics

http://www.ldgh.com.br/index.php/bioinformatics

We developed and mantain the following bioinformatics tools:. DANCE - Disease-Ancestry Network. DANCE is a graph-based web tool that allows to integrate and visualize information on human complex phenotypes and their GWAS-hits, as well as their risk allele frequencies in different populations. (. CNVice (Inbreeding Coefficients Estimation for CNV data) is a freely available R script for population genetics applications. (.

2

Publications

http://www.ldgh.com.br/index.php/sidemenu-papers

Publications of LDGH Members. Origin and dynamics of admixture in Brazilians and its effect on the pattern of deleterious mutations. Proc Natl Acad Sci U S A. 112(28):8696-701. Lima-Costa MF, Rodrigues LC, Barreto ML, Gouveia M, Horta BL, Mambrini J, Kehdy FS, Pereira A, Rodrigues-Soares F, Victora CG, Tarazona-Santos E; Epigen-Brazil group. Genomic ancestry and ethnoracial self-classification based on 5,871 community-dwelling Brazilians (The Epigen Initiative). Sci Rep. 5:9812. Fricke-Galindo I, Céspede...

3

CNVice

http://www.ldgh.com.br/index.php/cnvice

CNVice (Inbreeding Coefficients Estimation for CNV data) is a freely available R script for population genetics applications. CNVice performs the following analyses:. Estimates allele frequencies for a given population assuming Hardy-Weinberg equilibrium (HWE), using the expectation maximization algorithm as implemented in CoNVEM (Gaunt et al. 2010), conditioning on the observed diplotype frequencies. Estimates the population structure parameter. Download and Manual pages can be found at:.

4

Projects

http://www.ldgh.com.br/index.php/projects

Exploring the biomedical consequences of genetic differentiation of Native Americans. The goal of our laboratory is to identify genes involved in immunity and cancer that bear variants common in Native Americans and rare elsewhere, and to understand their effect on susceptibility to complex diseases. We study the pattern of genetic diversity of these genes, infer their evolutionary histories and functionally characterize the variants for which we have strong evidence of influence on complex diseases.

5

About

http://www.ldgh.com.br/index.php/about

We are located at the Department of Biology. Of the Federal University of Minas Gerais. Our goal is to understand the biomedical and clinical implications of the genomic variations of Latin Americans, focusing on nucleotide diversity and structural variation, with a specific focus on immune-related genes. 1] Salzano FM, Bortolini MC. 2001. The evolution and genetics of Latin American populations. 528 pp. Cambridge University Press.

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PROGRAMA DE PÓS-GRADUAÇAO EM GENÉTICA - Departamento de Biologia Geral - ICB - UFMG

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Coordenadores - Galeria Virtual. Oferta e ementa de disciplinas. Formulários, ofertas de disciplinas. Atas de reuniões do Colegiado. Verificação de autenticidade de documentos. Quadro do calendário do. Normas Gerais, normas do curso. Novos alunos por ano. 01 - Laboratório de Biodiversidade e Evolução Molecular (LBEM). Prof Dr. Fabrício Rodrigues dos Santos. UFMG - ICB - bloco L3, sala 244. 02 - Laboratório de Biotecnologia e Marcadores Moleculares. Prof Dr. Evanguedes Kalapothakis. UFMG - ICB - bloco L3,...

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PROGRAMA DE PÓS-GRADUAÇAO EM GENÉTICA - Departamento de Biologia Geral - ICB - UFMG

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Coordenadores - Galeria Virtual. Oferta e ementa de disciplinas. Formulários, ofertas de disciplinas. Atas de reuniões do Colegiado. Verificação de autenticidade de documentos. Quadro do calendário do. Normas Gerais, normas do curso. Novos alunos por ano. Nome em citações bibliográficas). Edmar Chartone de Souza. CHARTONE-SOUZA, E.). Nome em citações bibliográficas). FERREIRA, A. V. B.). Adriana Abalen Martins Dias. Dias, A. A. M.). NUNES, A. C.). Ana Lúcia Brunialti Godard. GODARD, A. L. B.). AZEVEDO, V...

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The Laboratory of Human Genetic Diversity (LDGH) overarching goal is to enhance our understanding of genetic diversity and the genetic bases of complex traits and diseases in native and admixed populations from Latin America. We integrate concepts and tools of population genetics, genetic epidemiology, computational biology and functional genetics to achieve this goal. We are located at the Department of Biology. Of the Federal University of Minas Gerais. We were at the SMBE 2015 in Vienna (July 12-16th).

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