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Welcome! - The Linder LabThe Linder Lab | Cytoskeletal Regulation of Vascular CellsPodosomes are highly dynamic, actin-rich adhesion structures of monocyte-derived cells, certain transformed fibroblasts and have recently also been discovered in an increasing number of other cell types. Related organelles called invadopodia are formed in cancer cells. Because they are mainly found in motile cells and control the activity of matrix metalloproteases, podosomes are thought to contribute to tissue invasion and matrix remodelling. Regulators of podosome turnover include tyrosine kinases, RhoGTP
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