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Kinetic Target Guided Synthesis.
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Molecular Probes
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Kinetic Target Guided Synthesis. Design, synthesis and photoactivation studies of fluorous photolabels. Kumar, A. B. Anderson, J. M. Manetsch, R. Org Biomol. Chem. The fourth research area of the Manetsch laboratory comprises the development of chemical tools for fluorescence or mass spectrometry based study of biologically relevant molecules or processes. We propose that specific labeling tools will facilitate and accelerate the discovery of potential biomarkers or drug targets within complex system...
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New Hampshire, Fall 2014. Kinetic Target Guided Synthesis. New Hampshire, Fall 2016. Tampa, Winter 2012. New Orleans, ACS Meeting 2013. Tampa, Winter 2012.
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Kinetic Target Guided Synthesis.
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Kinetic Target Guided Synthesis. PhD Carl von Ossietzky University Oldenburg, Germany. BS Le Moyne College. Dowgiallo.m@husky.neu.edu. BS University of Massachusetts, Boston. PhD University of South Florida. PhD Goa University, India. JSPS Postdoctoral Researcher, Kyoto University, Japan. PhD University of Ioannina, Greece. PhD University of Basel. Dr Raghupathi Neelarapu 2012-2014. Dr Yana Sakhno 2012-2013. Dr Niranjan Namelikonda 2009-2014. Dr David Flanigan 2009-2014. Dr Yijun Yiang 2009-2010.
Hit-to-Lead Optimization
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Kinetic Target Guided Synthesis. Hit-To-Lead Optimization for Neglected Diseases and Bacterial Infections. Our laboratory applies hit-to-lead optimization to the research of the following diseases:. Neglected tropical diseases: Malaria and leishmania. Bacterial diseases: MRSA and acinetobacter baumanni. Orally Bioavailable 6-Chloro-7-methoxy-4(1H)-quinolones Efficacious against Multiple Stages of Plasmodium. Quinolone-3-diarylethers: A new class of drugs for a new era of malaria eradication.
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Antimicrobials - The Kirby Laboratory
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Legionella Aerosols Cooling Towers Potable Water Supplies. T4SS-dependent Gram negative pathogens. Mechanisms of carbapenem resistance. Emerging antimicrobial resistance is threatening our ability to treat bacterial infection. The Infectious Disease Society of America indicates that in the next decade we will lose our ability to treat the most common causes of bacterial infection, the so called ESKAPE. The US Centers for Disease Control and Prevention additionally cite carbapenem-resistant. Therefore, we...
CRE Pathogens - The Kirby Laboratory
http://www.kirbylab.org/cre-pathogens.html
Legionella Aerosols Cooling Towers Potable Water Supplies. T4SS-dependent Gram negative pathogens. Mechanisms of carbapenem resistance. Are a cause of urinary tract, bloodstream, lung, and tissue infection. Alarmingly, multidrug-resistance is emerging at a rapid pace in this genus due to acquisition of large plasmids encoding a plethora of resistance elements. Epidemiologically, two emerging resistance mechanisms in the United States are especially notable -. Carbapemases, also known as KPC. Showed excel...
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