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maniatislab.columbia.edu

Maniatis Laboratory

This interest arose, in part, from our work in innate immunity, where we focused on the detailed mechanisms of interferon-β (IFN-β) gene regulation in response to virus infection. These studies involved the discovery and characterization of the IFN-β enhanceosome, and the elucidation of the signal transduction pathways necessary for the activation of the IFN-β gene. Image shows embryoid body demonstrating the cellular diversity occurring throughout neurogenesis.

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Maniatis Laboratory | maniatislab.columbia.edu Reviews
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This interest arose, in part, from our work in innate immunity, where we focused on the detailed mechanisms of interferon-β (IFN-β) gene regulation in response to virus infection. These studies involved the discovery and characterization of the IFN-β enhanceosome, and the elucidation of the signal transduction pathways necessary for the activation of the IFN-β gene. Image shows embryoid body demonstrating the cellular diversity occurring throughout neurogenesis.
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Maniatis Laboratory | maniatislab.columbia.edu Reviews

https://maniatislab.columbia.edu

This interest arose, in part, from our work in innate immunity, where we focused on the detailed mechanisms of interferon-β (IFN-β) gene regulation in response to virus infection. These studies involved the discovery and characterization of the IFN-β enhanceosome, and the elucidation of the signal transduction pathways necessary for the activation of the IFN-β gene. Image shows embryoid body demonstrating the cellular diversity occurring throughout neurogenesis.

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maniatislab.columbia.edu maniatislab.columbia.edu
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Maniatis Laboratory

http://maniatislab.columbia.edu/aboutus.php.html

Currently the Maniatis Lab is pursuing three directions: Protocadherin gene expression and function, ALS disease mechanisms and Innate Immunity. A consistent theme in all three projects is the use of molecular and cellular approaches to understand both basic biological and disease mechanisms. Several years ago we discovered a unique genomic organization of a cluster of genes encoding protocadherins, which are single pass trans-membrane proteins bearing immunoglobulin-like extracellular domains.

2

Maniatis Laboratory

http://maniatislab.columbia.edu/publications.php.html

Rubinstein R, Thu CA, Goodman KM, Wolcott HN, Bahna F, Mannepalli S, Ahlsen G, Chevee M, Halim A, Clausen H, Maniatis T. Shapiro L, Honig B. (2015) Molecular logic of neuronal self-recognition through protocadherin domain interactions. Cell. 2015 Oct 22;163(3):629-42. Chen, W.V. and Maniatis, T. 2013) Clustered Protocadherins. Development 40 (16) : 3297 - 302. Bilican, B., Serio, A., Shaw, C.E., Maniatis, T. Epub ahead of print]. Larabi, A., Devos, J.M., Ng Sze-Ling, Round, A., Maniatis, T. Serio, A....

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Maniatis Laboratory

http://maniatislab.columbia.edu/photos.php.html

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Maniatis Laboratory

http://maniatislab.columbia.edu/members.php.html

Thu, Chan Aye.

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Maniatis Laboratory

http://maniatislab.columbia.edu/calendar.php.html

Currently this is the Maniatis monthly lab calendar. Please note the new day and time. Meetings are held on Friday from 12pm - 2pm. For any schedule questions, please contact Catherine Friedl at 212.305.3885 or email her at: cf2651@cumc.columbia.edu. The Department of Biochemistry and Molecular Biophysics scheduled seminars. Thursday, February 11, 2016. Dr Ruth Lehmann, Professor of Cell Biology at NYU School of Medicine, HHMI. 4:00-5:00PM, HHSC Rm. 401 HHSC, 701 W.168th Street.

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colgateimmunology.blogspot.com colgateimmunology.blogspot.com

Colgate Immunology (and Virology) Blog: January 2012

http://colgateimmunology.blogspot.com/2012_01_01_archive.html

Colgate Immunology (and Virology) Blog. Discoveries from recent research in the immunology/virology literature, aimed at a general audience. Friday, January 13, 2012. Eosinophils and asthma in mice. Asthma is a “ type I hypersensitivity reaction. 8221; meaning that it is caused by the secretion of a particular type of antibody, IgE, following a Th2 immune response. Th2 responses are one of the major types of immunity, and target extracellular pathogens. The Th2 class of helper T cells. There is certainly...

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This interest arose, in part, from our work in innate immunity, where we focused on the detailed mechanisms of interferon-β (IFN-β) gene regulation in response to virus infection. These studies involved the discovery and characterization of the IFN-β enhanceosome, and the elucidation of the signal transduction pathways necessary for the activation of the IFN-β gene. Image shows embryoid body demonstrating the cellular diversity occurring throughout neurogenesis.

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