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ATTardi线粒体生物医学研究院

ATTardi线粒体生物医学研究院

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ATTardi线粒体生物医学研究院

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温州医科大学Attardi线粒体生物医学研究院 Attardi institute of mitochondrial biomedicine Wenzhou Medical College. 线粒体历来被誉为真核细胞的“动力站”,为机体提供90 以上的能量,是“生命之源”。 在已建立的分子遗传学研究平台基础上, 建立淋巴细胞系和转线粒体融合细胞系,进行细胞功能研究,运用生物化学、分子生物学以及其他学科的多种技术进一步阐明mtDNA突变所造成的线粒体功能缺陷,分析核基因 特别是核修饰基因 在与mtDNA突变相关的线粒体疾病表型表达中的调控作用,确定疾病相关的遗传标志物和预警靶点。 通过可被Lon降解的荧光标记的多肽底物,我们可以从合成化合物库及天然化合物库 如中药中的活性成分等 中寻找Lon 蛋白酶的特异性抑制剂或激活剂,这些化合物将具有抗肿瘤、治疗神经退行性疾病及抗衰老作用的潜在药物,这将使我们可以进一步开发出具有自主知识产权的相关药物。 访问量统计 7639133 浙ICP备06050237号 制作维护: 温州瑞星科技.

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ATTardi线粒体生物医学研究院

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Douglas C. Wallace. 浏览次数 3225 来源 未知 作者 未知 发布时间 2011-01-18 返回. 访问量统计 7639133 浙ICP备06050237号 制作维护: 温州瑞星科技.

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ATTardi线粒体生物医学研究院

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温州医科大学Attardi线粒体生物医学研究院 Attardi institute of mitochondrial biomedicine Wenzhou Medical College. 线粒体历来被誉为真核细胞的“动力站”,为机体提供90 以上的能量,是“生命之源”。 在已建立的分子遗传学研究平台基础上, 建立淋巴细胞系和转线粒体融合细胞系,进行细胞功能研究,运用生物化学、分子生物学以及其他学科的多种技术进一步阐明mtDNA突变所造成的线粒体功能缺陷,分析核基因 特别是核修饰基因 在与mtDNA突变相关的线粒体疾病表型表达中的调控作用,确定疾病相关的遗传标志物和预警靶点。 通过可被Lon降解的荧光标记的多肽底物,我们可以从合成化合物库及天然化合物库 如中药中的活性成分等 中寻找Lon 蛋白酶的特异性抑制剂或激活剂,这些化合物将具有抗肿瘤、治疗神经退行性疾病及抗衰老作用的潜在药物,这将使我们可以进一步开发出具有自主知识产权的相关药物。 访问量统计 7639133 浙ICP备06050237号 制作维护: 温州瑞星科技.

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ATTardi线粒体生物医学研究院

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浏览次数 6006 来源 未知 作者 未知 发布时间 2011-01-18 返回. 访问量统计 7639133 浙ICP备06050237号 制作维护: 温州瑞星科技.

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Attardi institute of mitochondrial. Biomedicine Wenzhou Medical College. Douglas C. Wallace. BioRxiv 重磅级成果 科学家发现人类细胞中线粒体 运行 温度可高达50. Cell Dis 线粒体与核内基因交流 借助表观遗传途径促进肿瘤进展. 访问量统计 7639133 浙ICP备06050237号 制作维护: 温州瑞星科技.

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