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MedChemBuzz | Medicinal chemistry blog – selected highlights from recent literature…Medicinal chemistry blog - selected highlights from recent literature…
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MedChemBuzz | Medicinal chemistry blog – selected highlights from recent literature… | medchembuzz.wordpress.com Reviews
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Medicinal chemistry blog - selected highlights from recent literature…
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MedChemBuzz | Medicinal chemistry blog – selected highlights from recent literature… | Page 2
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Medicinal chemistry blog – selected highlights from recent literature. Newer posts →. Enhancing solubility by disrupting crystal packing. March 7, 2011. Drug candidates can be classified, according to the BCS. System, into four groups on the basis of their permeability and aqueous solubility. Molecules with lower solubility tend to be more difficult to develop and are subject to closer scrutiny by regulatory bodies (. The latter approach is the subject of a. Twisting of fused rings. March 2, 2011. From s...
Disclaimer | MedChemBuzz
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Medicinal chemistry blog – selected highlights from recent literature. Whilst every effort has been made to avoid any errors or other misrepresentation of the articles discussed, the authors cannot be held responsible for the integrity or accuracy of any of the information presented on this blog. Please refer to the original literature for reference purposes. Enter your email address to subscribe to this blog and receive notifications of new posts by email. Join 84 other followers. MedChem Jobs – UK.
MDM2-p53 protein-protein interaction inhibitors | MedChemBuzz
https://medchembuzz.wordpress.com/2011/05/10/mdm2-p53-protein-protein-interaction-inhibitors
Medicinal chemistry blog – selected highlights from recent literature. GPCR structure and modeling. Improving Solubility using X-ray crystal structure data →. MDM2-p53 protein-protein interaction inhibitors. May 10, 2011. The successful development of inhibitors of protein-protein interactions remains a formidable challenge for medicinal chemists. An excellent review. Highlights some successes in this field and ascribes the low tractability of these targets to:. The tumor suppressor protein p53 acts as a...
Improving Solubility using X-ray crystal structure data | MedChemBuzz
https://medchembuzz.wordpress.com/2012/05/21/improving-solubility-using-x-ray-crystal-structure-data
Medicinal chemistry blog – selected highlights from recent literature. MDM2-p53 protein-protein interaction inhibitors. Improving Solubility using X-ray crystal structure data. May 21, 2012. From AstraZeneca provides a really interesting overview of the approach that they took to optimise the solubility of a series of GPR119 agonists. The initial lead compound 2. Click to print (Opens in new window). Click to email (Opens in new window). Share on Facebook (Opens in new window). May 21, 2012 at 7:54 pm.
Enhancing solubility by disrupting crystal packing | MedChemBuzz
https://medchembuzz.wordpress.com/2011/03/07/enhancing-solubility-by-disrupting-crystal-packing
Medicinal chemistry blog – selected highlights from recent literature. Optimization of plasma protein binding (again…). Discovery of MK-1220 (Hepatitis C NS3/4A protease inhibitor) →. Enhancing solubility by disrupting crystal packing. March 7, 2011. Drug candidates can be classified, according to the BCS. System, into four groups on the basis of their permeability and aqueous solubility. The latter approach is the subject of a. Increased dihedral angle/disruption of molecular symmetry (see example below).
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sussexdrugdiscovery.wordpress.com
October | 2014 | Sussex Drug Discovery Centre
https://sussexdrugdiscovery.wordpress.com/2014/10
Sussex Drug Discovery Centre. Medicinal, Chemistry and Biochemistry blog from the Sussex Drug Discovery Centre. Skip to primary content. Skip to secondary content. Sussex Drug Discovery Centre. Monthly Archives: October 2014. Alzheimer’s in a dish’ – A 3D cell culture model of Alzheimer’s disease. October 20, 2014. This month a group in the US have published an elegant study. Amyloid-β deposits in control (ReN-G) and FAD ReN (ReN-mGAP). This important work has not only provided experimental evidence supp...
sussexdrugdiscovery.wordpress.com
November | 2014 | Sussex Drug Discovery Centre
https://sussexdrugdiscovery.wordpress.com/2014/11
Sussex Drug Discovery Centre. Medicinal, Chemistry and Biochemistry blog from the Sussex Drug Discovery Centre. Skip to primary content. Skip to secondary content. Sussex Drug Discovery Centre. Monthly Archives: November 2014. In Silico Prediction of Off Target Activities of Chemical Probes. A recent publication highlights the importance of assessing broad selectivity and describes an in silico approach capable of predicting off target liabilities ( Antolín and Mestres, ACS Chemical Biology 2014, ahead o...
sussexdrugdiscovery.wordpress.com
September | 2014 | Sussex Drug Discovery Centre
https://sussexdrugdiscovery.wordpress.com/2014/09
Sussex Drug Discovery Centre. Medicinal, Chemistry and Biochemistry blog from the Sussex Drug Discovery Centre. Skip to primary content. Skip to secondary content. Sussex Drug Discovery Centre. Monthly Archives: September 2014. Can we predict compound precipitation in DMSO stocks? September 28, 2014. To determine if a physicochemical property could be identified as a correlating factor for increased precipitation rate in the Tox set compared to the fragment set , the MW, clogP, fsp3 (fraction of sp3 carb...
sussexdrugdiscovery.wordpress.com
February | 2015 | Sussex Drug Discovery Centre
https://sussexdrugdiscovery.wordpress.com/2015/02
Sussex Drug Discovery Centre. Medicinal, Chemistry and Biochemistry blog from the Sussex Drug Discovery Centre. Skip to primary content. Skip to secondary content. Sussex Drug Discovery Centre. Monthly Archives: February 2015. Toward a future of truly personalized cancer therapy. February 12, 2015. Targeted cancer therapies have produced substantial clinical results in the last decade, but most tumours eventually develop resistance to these drugs. Benes, Engelman and colleagues have recently described in.
sussexdrugdiscovery.wordpress.com
pbeswick | Sussex Drug Discovery Centre
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Sussex Drug Discovery Centre. Medicinal, Chemistry and Biochemistry blog from the Sussex Drug Discovery Centre. Skip to primary content. Skip to secondary content. Sussex Drug Discovery Centre. Toward a future of truly personalized cancer therapy. February 12, 2015. Targeted cancer therapies have produced substantial clinical results in the last decade, but most tumours eventually develop resistance to these drugs. Benes, Engelman and colleagues have recently described in. Or anaplastic lymphoma kinase (.
sussexdrugdiscovery.wordpress.com
December | 2014 | Sussex Drug Discovery Centre
https://sussexdrugdiscovery.wordpress.com/2014/12
Sussex Drug Discovery Centre. Medicinal, Chemistry and Biochemistry blog from the Sussex Drug Discovery Centre. Skip to primary content. Skip to secondary content. Sussex Drug Discovery Centre. Monthly Archives: December 2014. Highlights from Society of Medicines Research Meeting 4th December 2014. December 16, 2014. The Society for Medicines Research was hosting the Recent Disclosures of Clinical Candidates meeting on Thursday 4. Blood 9.5) whilst showing selectivity over the pro-inflammatory cytoki...
Angiogenesis and anti-angiogenic foods | MedchemBlog-medicinal chemistry and related sciences
http://medchemblog.blogspot.com/2010/07/angiogeneis-and-anti-angiogenic-foods.html
Angiogenesis and anti-angiogenic foods. 2 Comments so far. 160;Friday, July 02, 2010. This post shares the natural way of preventing cancer by eating healthy anti-angiogenic foods. William Li’s talk on topic “Can we eat to starve cancer? 8221; has been an inspiration behind this post. William Li’s research team. You can check the list here. After watching the list, I realize that we, knowingly or unknowingly, are eating many anti-angiogenic foods that can prevent the cancer. Yes, Mother Nature has a ...
MedchemBlog-medicinal chemistry and related sciences: June 2012
http://medchemblog.blogspot.com/2012_06_01_archive.html
How to work-up reaction using separatory funnel? Be the first to comment! 160;Monday, June 18, 2012. I want to share my bitter experience here. Once, while doing work-up (during shaking), I forgot to release the pressure. As soon as I kept the separatory funnel to stand, solvent splashed out of the separatory funnel through the stopper. Oh gosh! You can imagine the situation.:(. Posted by Med Chem. Subscribe to: Posts (Atom). Sign up for free email updates. How to work-up reaction using separatory funnel?
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Welcome to MedChemBio | MedChemBio
Skip to main content. MedChemBio klastr medicinální chemie a chemické biologie. Members of the MedChemBioBio Cluster. The Project is co-financed by the European Regional Development Fund and Czech Ministry of Industry and Trade.
Welcome to MedChemBio | MedChemBio
Skip to main content. MedChemBio klastr medicinální chemie a chemické biologie. DDPEO 2017 - XIII. ročník tradiční konference. 2 výroční konference BioSpot. DDPEO 2016 - XII. ročník tradiční konference. Projekt je spolufinancován Evropským fondem pro regionální rozvoj a Ministerstvem průmyslu a obchodu ČR.
Welcome to MedChemBio | MedChemBio
Skip to main content. MedChemBio klastr medicinální chemie a chemické biologie. Members of the MedChemBioBio Cluster. The Project is co-financed by the European Regional Development Fund and Czech Ministry of Industry and Trade.
MedchemBlog-medicinal chemistry and related sciences
Be the first to comment! 160;Sunday, October 28, 2012. It's a great pleasure to be a part of ChemCoachCarnival. That has been started at Justlikecooking. By See Arr Oh. He has asked people working in chemistry to answer few questions (as below) which can be helpful for those interested in chemistry. What you do in a standard "work day.". What kind of schooling/training/experience helped you get there? How does chemistry inform your work? Finally, a unique, interesting, or funny anecdote about your career.
MedChemBuzz | Medicinal chemistry blog – selected highlights from recent literature…
Medicinal chemistry blog – selected highlights from recent literature. Improving Solubility using X-ray crystal structure data. May 21, 2012. From AstraZeneca provides a really interesting overview of the approach that they took to optimise the solubility of a series of GPR119 agonists. The initial lead compound 2. A clinical candidate for treating type II diabetes. The paper also serves to illustrate and build upon the concepts described in the review that we blogged. Click to print (Opens in new window).
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The Medicinal Chemistry Core at Dana-Farber Cancer Institute | Home
Medicinal Chemistry Core at Dana-Farber Cancer Institute. Nathanael Gray, PhD. Sara Buhrlage, PhD. Hwan Geun Choi, PhD. We just purchased the Initiator microwave synthesizer. The first reaction in the new Medicinal Chemistry Core lab space was run in early 2011! Medicinal Chemistry Core at Dana-Farber Cancer Institute. 450 Brookline Avenue, Boston, MA 02215.
MedChem Discovery Consulting | William J. Greenlee
MedChem Discovery Consulting offers medicinal chemistry services for Lead Identification, Lead Optimization and Candidate Nomination. MedChem Discovery Consulting has experience in drug licensing, including due diligence activities, in multiple therapy areas. Services include third-party evaluation of lead and/or candidate structures and associated data, for suitability. MedChem Discovery Consulting offers medicinal chemistry services for Lead Identification, Lead Optimization and Candidate.
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MCE中国-小分子化合物行业领跑者（抑制剂,调节剂,激动剂和化合物库
Biochem Biophys Res Commun. 2015 May 29;461(2):378-82. EMBO J. 2015 Apr 9. pii: e201490376. J Steroid Biochem Mol Biol. 2015 Apr 9;152:34-44. Ann Rheum Dis. 2015 Apr 9. pii: annrheumdis-2014-207109. Int J Pharm. 2015 Apr 8. pii: S0378-5173(15)00316-6. Am J Pathol. 2015 Apr 6. pii: S0002-9440(15)00152-2. Antimicrob Agents Chemother. 2015 Jun;59(6):3482-92. PLoS Pathog. 2015 Mar 30;11(3):e1004758. PLoS Genet. 2015 Mar 27;11(3):e1005120. Cancer Cell Int. 2015 Mar 12;15:30. Virology. 2015 Mar;477:10-7. Cance...
