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This web page was produced as an assignment for Genetics 564 , an undergraduate capstone course at UW-Madison .

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This web page was produced as an assignment for Genetics 564 , an undergraduate capstone course at UW-Madison .
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2 homology
3 phylogeny
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7 modifications
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This web page was produced as an assignment for Genetics 564 , an undergraduate capstone course at UW-Madison .

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Specific Aims

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Conclusions and Future Directions. This web page was produced as an assignment for. An undergraduate capstone course at. The role of p130Cas in smooth vascular muscle cell migration in a diabetic mouse model. My primary goal is to understand the relationship between BCAR1 and increased blood glucose in cardiovascular disease. Of this study is to investigate the role that BCAR1 protein, p130Cas, plays in the cardiovascular disease risk factor diabetes mellitus. This will be studied using. Run 4-plex iTRAQ...

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Modifications

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Conclusions and Future Directions. This web page was produced as an assignment for. An undergraduate capstone course at. Why are post-translation protein modifications important? The complexity of an organism does not rely only on the size of its genome but rather on the size of non-coding regions within the organisms genome. These regions contribute to the size of the organisms proteome ( 1. Figure 1: Complexity increase from human genome vs. human proteome. Using NetPhos 2.0. Cooper GM. The Cell: A...

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Protein

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Conclusions and Future Directions. This web page was produced as an assignment for. An undergraduate capstone course at. Breast Cancer Anti-estrogen Resistance 1 (BCAR1). Figure 1: Structure of BCAR1 protein. BCAR1 protein sequences in model organisms. Phylogenetic tree constructions of BCAR1 protein conservation amongst organisms. Gene ontology of BCAR1. Protein interaction network associated with BCAR1. 8203;Protein domains on the BCAR1 protein. Breast cancer research and treatment. Web 28 Feb. 2016.

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Domains

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Conclusions and Future Directions. This web page was produced as an assignment for. An undergraduate capstone course at. Figure 1: 3 protein domains conserved on the BCAR1 protein. Figure 2: BCAR1 protein domains from SMART database. Figure 3: BCAR1 protein domains from PFAM database. SMART vs. PFAM. SH3 domains are key characteristics of Crk protein such as BCAR1 and are known to function in signaling pathways ( 2. The PFAM analysis also recognized the SH3 binding domain but also found a serine rich dom...

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Protein Interactions

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Conclusions and Future Directions. This web page was produced as an assignment for. An undergraduate capstone course at. Protein interaction networks are an simple visual way to view protein-protein interactions. Networks are important in understanding biological processes and their underlying mechanisms. By understanding the mechanisms of biological processes insights can be gained into abnormal processes and variants that cause disease. 1 http:/ www.uniprot.org/. 2 http:/ string-db.org/.

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Projects - Genetics 564

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Spring 2016 Student Projects. Matthew Busalacchi: Familial Melanoma and Pigmentation (MC1R). Salvador Carranza: Cystinosis (CTNS). Mikayla Gallenberger: Acute Lymphoblastic Leukemia (PAX5). Sara Grange: Synesthesia (KIAA0319). Aidan Holmes: Wilson Disease (ATP7B). Bailey Marquardt: Developmental Dyslexia (ROBO1). Troy Meikle: Autoimmune lymphoproliferative syndrome (FAS). Mary Mohr: Cardiovascular Disease in Women (BCAR1/p130CAS). Kathryn Ness: CHARGE Syndrome (CHD7). Tia Ramirez: FOXG1 Syndrome (FOXG1).

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